. "D\u016Fkaz dihydrosanguinarinu jako prvn\u00EDho metabolitu transformace sanguinarinu u potkana pomoc\u00ED kapalinov\u00E9 chromatografie-hmotnostn\u00ED spektrometrie"@cs . "Z(MSM6198959216)" . . "Klejdus, Bo\u0159ivoj" . "6"^^ . "8"^^ . . "NL - Nizozemsko" . "D\u016Fkaz dihydrosanguinarinu jako prvn\u00EDho metabolitu transformace sanguinarinu u potkana pomoc\u00ED kapalinov\u00E9 chromatografie-hmotnostn\u00ED spektrometrie"@cs . "Adult rats were orally administered with a single dose of sanguinarine (10 mg SA per 1 kg body weight) in 1.0 ml water. In the plasma and the liver, dihydrosanguinarine (DHSA) was identified as a SA metabolite by high performance liquid chromatography-electrospray ionization mass spectrometry (HPLC/ESI-MS). Significantly higher levels of DHSA were found in both the plasma and the liver in comparison with those of SA. SA and DHSA were not detected in the urine. The formation of DHSA might be the first step of SA detoxification in the organism and its subsequent elimination in phase II reactions. Benz[c]acridine (BCA), in the literature cited SA metabolite, was found neither in urine nor in plasma and liver." . "Kosina, Pavel" . . "\u0160im\u00E1nek, Vil\u00EDm" . . . . . . . "Adult rats were orally administered with a single dose of sanguinarine (10 mg SA per 1 kg body weight) in 1.0 ml water. In the plasma and the liver, dihydrosanguinarine (DHSA) was identified as a SA metabolite by high performance liquid chromatography-electrospray ionization mass spectrometry (HPLC/ESI-MS). Significantly higher levels of DHSA were found in both the plasma and the liver in comparison with those of SA. SA and DHSA were not detected in the urine. The formation of DHSA might be the first step of SA detoxification in the organism and its subsequent elimination in phase II reactions. Benz[c]acridine (BCA), in the literature cited SA metabolite, was found neither in urine nor in plasma and liver."@en . "Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences" . "[B4D755CEA66B]" . "Psotov\u00E1, Jitka" . . "RIV/61989592:15110/06:00003477!RIV07-MSM-15110___" . . . . "1570-0232" . "A liquid chromatographic-mass spectrometric evidence of dihydrosanguinarine as a first metabolite of sanguinarine transformation in rat"@en . . "15110" . "A liquid chromatographic-mass spectrometric evidence of dihydrosanguinarine as a first metabolite of sanguinarine transformation in rat"@en . "830" . "A liquid chromatographic-mass spectrometric evidence of dihydrosanguinarine as a first metabolite of sanguinarine transformation in rat" . . . "Kub\u00E1\u0148, Vlastimil" . "RIV/61989592:15110/06:00003477" . . "8"^^ . "Dosp\u011Bl\u00FDm potkan\u016Fm byl or\u00E1ln\u011B aplikov\u00E1na sanguinarin (10 mg/kg t\u011Blesn\u00E9 hmotnosti) v 1.0 ml vody. Dihydrosanguinarin byl identifikov\u00E1n pomoc\u00ED kapalinov\u00E9 chromatografie- hmotnostn\u00ED spektrometrie jako metabolit sanguinarinu v plazm\u011B a j\u00E1trech, jeho hladina byla vy\u0161\u0161\u00ED ne\u017E hladina sanguinarinu. Dihydrosanguinarin ani sanguinarin nebyly nalezeny v mo\u010Di. Tvorba dihydrosanguinarinu je pravd\u011Bpodobm\u011B prvn\u00EDm krokem detoxifikace sanguinarinu. Benz[c]akridin, v literatu\u0159e uv\u00E1d\u011Bn\u00FD metabolit sanguinarinu, nebyl nalezen v mo\u010Di, plazm\u011B ani v j\u00E1trech."@cs . "Ve\u010De\u0159a, Rostislav" . . "463562" . . . . "165-172" . . "Ulrichov\u00E1, Jitka" . . "Quaternary benzo[c]phenanthridine alkaloid; Sanguinarine; Rat; Metabolite; Liquid chromatography-mass spectrometry; Liver; Plasma; Dihydrosanguinarine; Benz[c]acridine"@en . "1" . . . "A liquid chromatographic-mass spectrometric evidence of dihydrosanguinarine as a first metabolite of sanguinarine transformation in rat" . "Vi\u010Dar, Jaroslav" .