"Monoklon\u00E1ln\u00ED gamapatie nejist\u00E9ho v\u00FDznamu" . . . "mimo\u0159.p\u0159." . "1"^^ . "Postgradu\u00E1ln\u00ED medic\u00EDna" . "1"^^ . . . . . "RIV/61989592:15110/06:00002783!RIV07-MSM-15110___" . "Monoklon\u00E1ln\u00ED gamapatie nejist\u00E9ho v\u00FDznamu"@cs . . "15110" . "486762" . . "42-49" . "N\u00E1pln\u00ED sd\u011Blen\u00ED, v\u011Bnovan\u00E9mu problematice monoklon\u00E1ln\u00ED gamapatie nejist\u00E9ho v\u00FDznamu (MGNV) je vymezen\u00ED a historie pojmu, p\u0159ehled diagnostick\u00FDch krit\u00E9ri\u00ED v\u010Detn\u011B diferenci\u00E1ln\u00ED diagnostiky, epidemiologie a klinick\u00E9ho obrazu tohoto stavu. Speci\u00E1ln\u00ED pozornost je v\u011Bnov\u00E1na ot\u00E1zk\u00E1m etiologie a patogenezy v\u010Detn\u011B modelu line\u00E1rn\u00ED %22multistep%22 molekul\u00E1rn\u00ED patogeneze MGNV a problematice evoluce v malign\u00ED monoklon\u00E1ln\u00ED gamapatii zejm\u00E9na v mnoho\u010Detn\u00FD myelom. Vy\u00FAst\u011Bn\u00EDm sd\u011Blen\u00ED je subklasifikace stavu v\u010Detn\u011B n\u00E1stinu tzv. %22evolving%22 a %22non-evolving%22 typu a z\u00E1sady dispenz\u00E1rn\u00ED p\u00E9\u010De z hlediska ka\u017Edodenn\u00ED klinick\u00E9 praxe." . . "monoclonal gammopathy of undetermined significance; epidemiology; diagnostic criteria; differential diagnosis; clinical significance"@en . "Monoklon\u00E1ln\u00ED gamapatie nejist\u00E9ho v\u00FDznamu" . "Monoclonal gammopathy of undetermined significance"@en . "The objective of this article, devoted to the issue of monoclonal gammopathy of undetermined significance (MGUS) is the definition of its conception, review of diagnostic criteria as well as differential diagnosis, epidemiology and clinical picture of this state. Special accent is put on the questions of etiology and pathogenesis including the model of linear %22multistep%22 molecular pathogenesis of MGUS and the issue of evolution into malignant monoclonal gammopathy especially in multiple myeloma. The aim of the report is the subclassification of the state including the conception of so called %22evolving%22 and %22non-evolving%22 type and the principle of dispensary management from the point of routine practice."@en . "\u0160\u010Dudla, Vlastimil" . . "Monoklon\u00E1ln\u00ED gamapatie nejist\u00E9ho v\u00FDznamu"@cs . . . "RIV/61989592:15110/06:00002783" . "[11A7EC7B3A42]" . . "1212-4184" . . . . "Monoclonal gammopathy of undetermined significance"@en . "8" . "N\u00E1pln\u00ED sd\u011Blen\u00ED, v\u011Bnovan\u00E9mu problematice monoklon\u00E1ln\u00ED gamapatie nejist\u00E9ho v\u00FDznamu (MGNV) je vymezen\u00ED a historie pojmu, p\u0159ehled diagnostick\u00FDch krit\u00E9ri\u00ED v\u010Detn\u011B diferenci\u00E1ln\u00ED diagnostiky, epidemiologie a klinick\u00E9ho obrazu tohoto stavu. Speci\u00E1ln\u00ED pozornost je v\u011Bnov\u00E1na ot\u00E1zk\u00E1m etiologie a patogenezy v\u010Detn\u011B modelu line\u00E1rn\u00ED %22multistep%22 molekul\u00E1rn\u00ED patogeneze MGNV a problematice evoluce v malign\u00ED monoklon\u00E1ln\u00ED gamapatii zejm\u00E9na v mnoho\u010Detn\u00FD myelom. Vy\u00FAst\u011Bn\u00EDm sd\u011Blen\u00ED je subklasifikace stavu v\u010Detn\u011B n\u00E1stinu tzv. %22evolving%22 a %22non-evolving%22 typu a z\u00E1sady dispenz\u00E1rn\u00ED p\u00E9\u010De z hlediska ka\u017Edodenn\u00ED klinick\u00E9 praxe."@cs . . "CZ - \u010Cesk\u00E1 republika" . "8"^^ . "Z(MSM6198959205)" .