. "STRUKTURA A AKTIVACE PROTEINKIN\u00C1ZY C (PKC)" . . "Proteinkin\u00E1zy C (PKC) pat\u0159\u00ED mezi nereceptorov\u00E9 protein-serin/treoninkin\u00E1zy a zahrnuj\u00ED rodinu rozd\u00EDln\u00FDch enzymov\u00FDch izoforem, kter\u00E9 se li\u0161\u00ED sv\u00FDmi regula\u010Dn\u00EDmi a katalytick\u00FDmi vlastnostmi. Rozd\u011Bluj\u00ED se do t\u0159\u00ED skupin - na tzv. konven\u010Dn\u00ED (c-), nov\u00E9 (n-) a atypick\u00E9 (a-)PKC. Jsou kl\u00ED\u010Dov\u00FDmi regul\u00E1tory bun\u011B\u010Dn\u00FDch funkc\u00ED a hraj\u00ED d\u016Fle\u017Eitou roli v mnoha bun\u011B\u010Dn\u00FDch sign\u00E1ln\u00EDch drah\u00E1ch. Mechanismus aktivace PKC je nejl\u00E9pe pops\u00E1n u cPKC a je z\u00E1kladem pro objasn\u011Bn\u00ED aktivace dal\u0161\u00EDch izoforem PKC i jin\u00FDch p\u0159\u00EDbuzn\u00FDch kin\u00E1z."@cs . "STRUKTURA A AKTIVACE PROTEINKIN\u00C1ZY C (PKC)"@cs . . . "[6A10DEBE6D35]" . . . "\u010Ceskoslovensk\u00E1 fyziologie" . . "54" . "RIV/61989592:15110/05:00001979" . "15110" . . . "136-140" . "STRUKTURA A AKTIVACE PROTEINKIN\u00C1ZY C (PKC)"@cs . . "CZ - \u010Cesk\u00E1 republika" . "Rypka, Miroslav" . "1210-6313" . . "STRUCTURE AND ACTIVATION OF PROTEINKINASES C (PKCs)"@en . . "STRUKTURA A AKTIVACE PROTEINKIN\u00C1ZY C (PKC)" . "Proteinkinases C (PKCs) comprise non-receptor serin/threonin protein kinases involving family of distinct enzyme isoform with different regulatory and catalytic properties. The PKC family is divided into three subfamilies: the conventional (cPKC), novel (nPKC) and atypical (aPKC). They are key regulators of cell functions and play important role in many cell signaling pathways. PKC activation mechanism is best understood in cPKC thus forming a basis for understanding the activation of other PKC isoforms as well as related kinases of AGC superfamily."@en . "Vesel\u00FD, Jaroslav" . "P(1P05OC064), P(OC B17.20)" . . . "RIV/61989592:15110/05:00001979!RIV07-MSM-15110___" . "4" . "5"^^ . . . "Uherkov\u00E1, Lenka" . "545002" . "Proteinkin\u00E1zy C (PKC) pat\u0159\u00ED mezi nereceptorov\u00E9 protein-serin/treoninkin\u00E1zy a zahrnuj\u00ED rodinu rozd\u00EDln\u00FDch enzymov\u00FDch izoforem, kter\u00E9 se li\u0161\u00ED sv\u00FDmi regula\u010Dn\u00EDmi a katalytick\u00FDmi vlastnostmi. Rozd\u011Bluj\u00ED se do t\u0159\u00ED skupin - na tzv. konven\u010Dn\u00ED (c-), nov\u00E9 (n-) a atypick\u00E9 (a-)PKC. Jsou kl\u00ED\u010Dov\u00FDmi regul\u00E1tory bun\u011B\u010Dn\u00FDch funkc\u00ED a hraj\u00ED d\u016Fle\u017Eitou roli v mnoha bun\u011B\u010Dn\u00FDch sign\u00E1ln\u00EDch drah\u00E1ch. Mechanismus aktivace PKC je nejl\u00E9pe pops\u00E1n u cPKC a je z\u00E1kladem pro objasn\u011Bn\u00ED aktivace dal\u0161\u00EDch izoforem PKC i jin\u00FDch p\u0159\u00EDbuzn\u00FDch kin\u00E1z." . . . "\u010Cervenkov\u00E1, Kate\u0159ina" . "STRUCTURE AND ACTIVATION OF PROTEINKINASES C (PKCs)"@en . . "proteinkinase C (PKC); isoforms; activation; phosphorylation"@en . "5"^^ . . . "5"^^ . "Poczatkov\u00E1, Hana" .