. . . "Proteinkin\u00E1za C (PKC) a jej\u00ED role v metabolismu mastn\u00FDch kyselin a gluk\u00F3zy" . "Nereceptorov\u00E9 protein-serin/treoninkin\u00E1zy C (PKC) jsou d\u016Fle\u017Eit\u00FDmi regul\u00E1tory bun\u011B\u010Dn\u00FDch funkc\u00ED. Uplat\u0148uj\u00ED se v \u0159ad\u011B bun\u011B\u010Dn\u00FDch sign\u00E1ln\u00EDch drah. Zv\u00FD\u0161en\u00E9 koncentrace voln\u00FDch mastn\u00FDch kyselin anebo gluk\u00F3zy v plazm\u011B, kter\u00E9 se vyskytuj\u00ED zejm\u00E9na v postprandi\u00E1ln\u00ED period\u011B, mohou aktivovat PKC ve tk\u00E1n\u00EDch. Aktivovan\u00E9 PKC fosforyluj\u00ED ur\u010Dit\u00E9 \u010Dl\u00E1nky inzul\u00EDnov\u00E9 sign\u00E1ln\u00ED kask\u00E1dy. P\u0159edpokl\u00E1d\u00E1 se, \u017Ee PKC pat\u0159\u00ED ke kl\u00ED\u010Dov\u00FDm medi\u00E1tor\u016Fm inzul\u00EDnov\u00E9 rezistence vyvolan\u00E9 voln\u00FDmi mastn\u00FDmi kyselinami anebo vysok\u00FDmi koncentracemi gluk\u00F3zy" . . "127-131" . . . . . . "Poczatkov\u00E1, Hana" . "Vesel\u00FD, Jaroslav" . "Proteinkin\u00E1za C (PKC) a jej\u00ED role v metabolismu mastn\u00FDch kyselin a gluk\u00F3zy"@cs . "Nereceptorov\u00E9 protein-serin/treoninkin\u00E1zy C (PKC) jsou d\u016Fle\u017Eit\u00FDmi regul\u00E1tory bun\u011B\u010Dn\u00FDch funkc\u00ED. Uplat\u0148uj\u00ED se v \u0159ad\u011B bun\u011B\u010Dn\u00FDch sign\u00E1ln\u00EDch drah. Zv\u00FD\u0161en\u00E9 koncentrace voln\u00FDch mastn\u00FDch kyselin anebo gluk\u00F3zy v plazm\u011B, kter\u00E9 se vyskytuj\u00ED zejm\u00E9na v postprandi\u00E1ln\u00ED period\u011B, mohou aktivovat PKC ve tk\u00E1n\u00EDch. Aktivovan\u00E9 PKC fosforyluj\u00ED ur\u010Dit\u00E9 \u010Dl\u00E1nky inzul\u00EDnov\u00E9 sign\u00E1ln\u00ED kask\u00E1dy. P\u0159edpokl\u00E1d\u00E1 se, \u017Ee PKC pat\u0159\u00ED ke kl\u00ED\u010Dov\u00FDm medi\u00E1tor\u016Fm inzul\u00EDnov\u00E9 rezistence vyvolan\u00E9 voln\u00FDmi mastn\u00FDmi kyselinami anebo vysok\u00FDmi koncentracemi gluk\u00F3zy"@cs . "3" . . . . . . . "The role of PKC in the metabolism of free fatty acids and glucose"@en . "Proteinkin\u00E1za C (PKC) a jej\u00ED role v metabolismu mastn\u00FDch kyselin a gluk\u00F3zy" . . . "Proteinkin\u00E1za C (PKC) a jej\u00ED role v metabolismu mastn\u00FDch kyselin a gluk\u00F3zy"@cs . "15110" . "4"^^ . "P(1P05OC064), P(OC B17.20)" . "Non-receptor serin/threonin protein kinases C (PKCs) are important regulators of cell metabolism. They are involved in many cell signaling pathways. Elevated plasma free fatty acids and/or glucose can activate PKC isoforms in body tissues. Activated PKCs phosphorylate several components of insulin signaling cascade. PKCs have been implicated as the key mediators of the FFA- and/or high-glucose-induced insulin resistance."@en . "\u010Ceskoslovensk\u00E1 fyziologie" . "Riegrov\u00E1, Dagmar" . . "RIV/61989592:15110/05:00001978!RIV07-MSM-15110___" . . "5"^^ . "1210-6313" . . "4"^^ . "RIV/61989592:15110/05:00001978" . "539379" . "Rypka, Miroslav" . "54" . "[815A87A9A535]" . "CZ - \u010Cesk\u00E1 republika" . . "Protein kinase C (PKC); insulin; insulin resistance; free fatty acids (FFA); hyperglycaemia"@en . "The role of PKC in the metabolism of free fatty acids and glucose"@en .