. "539759" . "p53 - Prognostic factor of malignant transformation of barrett's esophagus."@en . "p53 - prognostick\u00FD faktor malign\u00ED transformace u Baretovho j\u00EDcnu"@cs . "Kr\u00E1l, Vladim\u00EDr" . . "8"^^ . . . . "Nejsignifikantn\u011Bj\u0161\u00ED prekancerozi rakoviny j\u00EDcnu je Baret\u016Fv j\u00EDcen. Riziko malign\u00ED transformace zav\u00EDs\u00ED od stupn\u011B dysplastick\u00FDch zm\u011Bn sliznice. Studie opisuje na vzorku 20pacient\u016F s Baretov\u00FDm j\u00EDcnem korelaci mezi stupn\u011Bm dysplazie Baretovho j\u00EDcnu a mutaci nebo zm\u011Bnenou expres\u00ED p53."@cs . . "4"^^ . "Esophagus; Esophageal cancer; p53; Barrett's esophagus"@en . "p53 - Prognostic factor of malignant transformation of barrett's esophagus." . "Aujesk\u00FD, Ren\u00E9" . "[A31E610C6DE1]" . "Dr\u00E1\u010D, Petr" . "9"^^ . . . "The most significant precancerosis in the esophageal cancer is Barrett's esophagus. The risk of malignant transformationis determined primarily in accordance with the degree of dysplastic alterations of the mucosa. Indicationof %22preventive%22 extirpation of the esophagus should be supported by other factors, for example by detection of p53mutation or expression.The study reports on the evaluation of a group of 20 patients with Barrett's esophagus treated at the 1st Departmentof Surgery, the p53 level and its correlation with histological findings evaluated in these patients.A good correlation was found between the grade of Barrett's esophagus dysplasia and high p53 positivity. This correlationwas also confirmed by detection of early carcinoma in patients with %22preventive%22 extirpation of the esophagusdue to a high-grade dysplasia.Preliminary results show that examination of p53 level in specimens taken from the esophageal mucosa may behelpf" . . "Z(MSM6198959216)" . . . "CZ - \u010Cesk\u00E1 republika" . "Neoral, \u010Cestm\u00EDr" . . . "Klein, Ji\u0159\u00ED" . "p53 - Prognostic factor of malignant transformation of barrett's esophagus." . "The most significant precancerosis in the esophageal cancer is Barrett's esophagus. The risk of malignant transformationis determined primarily in accordance with the degree of dysplastic alterations of the mucosa. Indicationof %22preventive%22 extirpation of the esophagus should be supported by other factors, for example by detection of p53mutation or expression.The study reports on the evaluation of a group of 20 patients with Barrett's esophagus treated at the 1st Departmentof Surgery, the p53 level and its correlation with histological findings evaluated in these patients.A good correlation was found between the grade of Barrett's esophagus dysplasia and high p53 positivity. This correlationwas also confirmed by detection of early carcinoma in patients with %22preventive%22 extirpation of the esophagusdue to a high-grade dysplasia.Preliminary results show that examination of p53 level in specimens taken from the esophageal mucosa may behelpf"@en . "\u013Dubu\u0161sk\u00E1, Lucie" . "Hajd\u00FAch, Mari\u00E1n" . "149" . . . . "1" . "p53 - Prognostic factor of malignant transformation of barrett's esophagus."@en . . "Vrba, Radek" . "15110" . . "1213-8118" . "Biomedical Papers" . . "Bohanes, Tom\u00E1\u0161" . . "141-144" . "p53 - prognostick\u00FD faktor malign\u00ED transformace u Baretovho j\u00EDcnu"@cs . . . "RIV/61989592:15110/05:00001933!RIV06-MSM-15110___" . "RIV/61989592:15110/05:00001933" . .