"[37A519E74E96]" . . "P(GP303/04/P074), Z(MSM6198959216)" . "Antimitotic drugs; Drug metabolism; Cytochromes P450; Nuclear receptors; Gene expression"@en . "Disruptory mikrotubul\u016F a jejich interakce s biotransforma\u010Dn\u00EDmi enzymy"@cs . "CZ - \u010Cesk\u00E1 republika" . "Disruptory mikrotubul\u016F a jejich interakce s biotransforma\u010Dn\u00EDmi enzymy"@cs . . . "RIV/61989592:15110/05:00001919" . "530205" . . "149" . "Microtubule disruptors, widely known as antimitotics, have broad applications in human medicine, especially as anti-neoplastic agents. They are subject to biotransformation within human body frequently involving cytochromes P450. Therefore antimitotics are potential culprits of drug-drug interactions on the level of activity as well as expression of cytochromes P450. This review discusses the effects of four well-known natural antimitotics: colchicine, taxol (paclitaxel), vincristine, and vinblastine, and a synthetic microtubule disruptor nocodazole on transcriptional activity of glucocorticoid and aryl hydrocarbon receptors. It appears that microtubules disarray restricts the signaling by these two nuclear receptors regardless of cell cycle phase. Consequently, intact microtubules play an important role in the regulation of expression of cytochromes P450, which are under direct or indirect control of the two nuclear receptors." . . . "15110" . "2"^^ . "213-216" . "Microtubule disruptors, widely known as antimitotics, have broad applications in human medicine, especially as anti-neoplastic agents. They are subject to biotransformation within human body frequently involving cytochromes P450. Therefore antimitotics are potential culprits of drug-drug interactions on the level of activity as well as expression of cytochromes P450. This review discusses the effects of four well-known natural antimitotics: colchicine, taxol (paclitaxel), vincristine, and vinblastine, and a synthetic microtubule disruptor nocodazole on transcriptional activity of glucocorticoid and aryl hydrocarbon receptors. It appears that microtubules disarray restricts the signaling by these two nuclear receptors regardless of cell cycle phase. Consequently, intact microtubules play an important role in the regulation of expression of cytochromes P450, which are under direct or indirect control of the two nuclear receptors."@en . "1213-8118" . . "2"^^ . . "Microtubule disruptors and their interaction with biotransformation enzymes" . "Biomedical Papers" . "Microtubule disruptors and their interaction with biotransformation enzymes"@en . . "2" . . . "Disruptory mikrotubul\u016F, zn\u00E1m\u011Bj\u0161\u00ED pod n\u00E1zvem antimitotika, maj\u00ED \u0161irok\u00E9 uplatn\u011Bn\u00ED v hum\u00E1nn\u00ED medic\u00EDn\u011B, nej\u010Dast\u011Bji jako antineoplastika. Tyto l\u00E1tky podl\u00E9haj\u00ED v lidsk\u00E9m t\u011Ble biotransformaci, kter\u00E1 je obvykle katalyzov\u00E1na cytochromy P450. Proto jsou antimitotika mo\u017Enou p\u0159\u00ED\u010Dinou mezil\u00E9kov\u00FDch interakc\u00ED jak na \u00FArovni aktivity, tak exprese cytochrom\u016F P450. Toto review diskutuje \u00FA\u010Dinky \u010Dty\u0159 nejzn\u00E1m\u011Bj\u0161\u00EDch antimitotik p\u0159\u00EDrodn\u00EDho p\u016Fvodu: kolchicinu, taxolu (paklitaxelu), vinkristinu a vinblastinu, a tak\u00E9 syntetick\u00E9ho disruptoru mikrotubul\u016F nokodazolu, na transkrip\u010Dn\u00ED aktivitu glukokortikoidn\u00EDho a aryl hydrokarbonov\u00E9ho receptoru. Liter\u00E1rn\u00ED data nazna\u010Duj\u00ED, \u017Ee poru\u0161en\u00ED mikrotubul\u016F limituje signalizaci prov\u00E1d\u011Bnou t\u011Bmito dv\u011Bma receptory a to nez\u00E1visle na f\u00E1zi bun\u011B\u010Dn\u00E9ho cyklu. Z toho vypl\u00FDv\u00E1, \u017Ee mikrotubuly hraj\u00ED d\u016Fle\u017Eitou \u00FAlohu v regulaci exprese cytochrom\u016F P450, kter\u00E9 jsou pod p\u0159\u00EDmou \u010Di nep\u0159\u00EDmou kontrolou t\u011Bchto dvou nukle\u00E1rn\u00EDch receptor\u016F."@cs . "RIV/61989592:15110/05:00001919!RIV06-MSM-15110___" . "4"^^ . "Dvo\u0159\u00E1k, Zden\u011Bk" . "Microtubule disruptors and their interaction with biotransformation enzymes" . "Modriansk\u00FD, Martin" . . . . . "Microtubule disruptors and their interaction with biotransformation enzymes"@en . . . . . .