"[1AC83C516B81]" . "6" . "Dvo\u0159\u00E1k, Zden\u011Bk" . "P(GP303/04/P074), Z(MSM6198959216)" . . "Superfamily of cytochrome P450 enzymes (CYPs), a distinctive enzyme system by which human body defends itself against toxic compounds, is the subject of a complex regulation process involving various mechanisms, on the levels of expression and activity. Apart from physiological factors, several patho-physiological ones such as inflammation, infection, and stress affect CYP expression. The aim of this review is to summarize the current knowledge on the role of microtubules network in the regulation of drug metabolizing CYPs. Experiments on human and animal cell models revealed that microtubules disruption severely impaired basal and inducible expression of human CYP 1A1, 2B6, 2C8, 2C9, 2C19, and 3A4, and rat CYP 1A2, 2B1, 2B2, and 3A23. Inhibition of aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR) transcriptional activity by microtubules disarray was found to be responsible for the suppressed CYP enzymes expression. However, the mechanism by which microtubules interfering agents (MIAs)"@en . . "Role of Microtubules Network in CYP Genes Expression" . . "Role of Microtubules Network in CYP Genes Expression" . . . "Role of Microtubules Network in CYP Genes Expression"@en . "RIV/61989592:15110/05:00001915" . "8"^^ . . . . "NL - Nizozemsko" . "Current Drug Metabolism" . "Role mikrotubul\u00E1rn\u00ED s\u00EDt\u011B v expresi gen\u016F CYP"@cs . . "Ulrichov\u00E1, Jitka" . . . "15110" . . . . "1389-2002" . "545-552" . "Modriansk\u00FD, Martin" . . "3"^^ . "6" . . "Nadrodina enzym\u016F cytochromu P450 (CYP), jedine\u010Dn\u00FD syst\u00E9m, pomoc\u00ED n\u011Bho\u017E se lidsk\u00E9 t\u011Blo br\u00E1n\u00ED proti toxick\u00FDm l\u00E1tk\u00E1m, je regulov\u00E1n na \u00FArovni exprese a aktivity v komplexn\u00EDm procesu zahrnuj\u00EDc\u00EDm nejr\u016Fzn\u011Bj\u0161\u00ED mechanismy. Krom\u011B fyziologick\u00FDch faktor\u016F, n\u011Bkter\u00E9 patofyziologick\u00E9 faktory jako je z\u00E1n\u011Bt, infekce a stres ovliv\u0148uj\u00ED expresi CYP. C\u00EDlem tohoto review je sumarizovat sou\u010Dasn\u00E9 poznatky o \u00FAloze mikrotubul\u00E1rn\u00ED s\u00EDt\u011B v regulaci CYP metabolizuj\u00EDc\u00EDch l\u00E9\u010Diva. Experimenty na lidsk\u00FDch a zv\u00ED\u0159ec\u00EDch bun\u011B\u010Dn\u00FDch modelech ukazuj\u00ED, \u017Ee poru\u0161en\u00ED integrity mikrotubul\u016F z\u00E1va\u017En\u011B naru\u0161uje baz\u00E1ln\u00ED a inducibiln\u00ED expresi lidsk\u00FDch CYP1A1, 2B6, 2C8, 2C9, 2C19, a 3A4, a potkan\u00EDch CYP1A2, 2B1, 2B2, a 3A23. Bylo zji\u0161t\u011Bno, \u017Ee naru\u0161en\u00ED mikrotubul\u016F zp\u016Fsobuje inhibici aryl uhlovod\u00EDkov\u00E9ho receptoru (AhR) a glukokortikoidn\u00EDho receptoru (GR), co\u017E v d\u016Fsledku vede ke sn\u00ED\u017Een\u00ED exprese CYP enzym\u016F. Ale mechanismus, kter\u00FDm l\u00E1tky ovliv\u0148uj\u00EDc\u00ED mikrotubuly (LOM) inhibuj\u00ED transkrip\u010Dn\u00ED aktivity GR a AhR nen\u00ED je\u0161t\u011B zcela pochopen. Existuje n\u011Bkolik n\u00E1znak\u016F, \u017E"@cs . "Superfamily of cytochrome P450 enzymes (CYPs), a distinctive enzyme system by which human body defends itself against toxic compounds, is the subject of a complex regulation process involving various mechanisms, on the levels of expression and activity. Apart from physiological factors, several patho-physiological ones such as inflammation, infection, and stress affect CYP expression. The aim of this review is to summarize the current knowledge on the role of microtubules network in the regulation of drug metabolizing CYPs. Experiments on human and animal cell models revealed that microtubules disruption severely impaired basal and inducible expression of human CYP 1A1, 2B6, 2C8, 2C9, 2C19, and 3A4, and rat CYP 1A2, 2B1, 2B2, and 3A23. Inhibition of aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR) transcriptional activity by microtubules disarray was found to be responsible for the suppressed CYP enzymes expression. However, the mechanism by which microtubules interfering agents (MIAs)" . . "541419" . "Role of Microtubules Network in CYP Genes Expression"@en . . "3"^^ . . "RIV/61989592:15110/05:00001915!RIV06-MSM-15110___" . "Cytochrome P450; regulation; cellular signalling; microtubules; nuclear receptors"@en . . "Role mikrotubul\u00E1rn\u00ED s\u00EDt\u011B v expresi gen\u016F CYP"@cs . .