"Defects in DNA mismatch repair system are involved in carcinogenesis of sporadic and inherited human cancers. We assessed the feasibility of using immunohistochemistry to detect tumors with DNA mismatch repair deficiency. We analyzed 81 samples (74 colon cancers (CC), 1 colon dysplasia and 6 extracolonic cancers) for hMLH1 and hMSH2 protein expression, microsatellite instability (MSI) and/or mutational analysis."@en . "Immunohistochemical detection of the hMLH1 a hMSH2 proteins in hereditary non-polyposis colon cancer and sporadic colon cancer"@en . . . . "Plevov\u00E1, Pavl\u00EDna" . "Sedl\u00E1kov\u00E1, Eva" . "K\u0159epelov\u00E1, Anna" . . "[A671DDD1F44C]" . "Hor\u00E1\u010Dek, Jaroslav" . "Foretov\u00E1, Lenka" . "4" . "SK - Slovensk\u00E1 republika" . "0028-2685" . . "567337" . "Immunohistochemical detection of the hMLH1 a hMSH2 proteins in hereditary non-polyposis colon cancer and sporadic colon cancer"@en . "14"^^ . "Pape\u017Eov\u00E1, Martina" . "Zapletalov\u00E1, Jana" . . "Nieslanik, Jaroslav" . "Imunohistochemick\u00E1 detekce hMLH1 a hMSH2 protein\u016F u heredit\u00E1rn\u00EDch nepolyp\u00F3zn\u00EDch a sporadick\u00FDch karcinom\u016F tlust\u00E9ho st\u0159eva"@cs . "Provedli jsme vy\u0161et\u0159en\u00ED exprese protein\u016F hMLH1 a hMSH2, nestability mikrosatelit\u016F a/nebo muta\u010Dn\u00ED anal\u00FDzu v 81 vzorc\u00EDch (74 kolorekt\u00E1ln\u00EDch karcinomech, 1 dyspl\u00E1zii tlust\u00E9ho st\u0159eva a 6 extrakolick\u00FDch n\u00E1dorech). D\u00E1le jsme provedli metaanal\u00FDzu publikovan\u00FDch dat, kter\u00E9 se t\u00FDkaj\u00ED imunohistochemick\u00E9 detekce protein\u016F hMLH1/hMSH2. Imunohistochemick\u00E1 detekce exprese protein hMLH1 a hMSH2 je u\u017Eite\u010Dnou metodou k predikci p\u0159\u00EDtomnosti deficitu oprav chybn\u00E9ho p\u00E1rov\u00E1n\u00ED b\u00E1z\u00ED, a\u010Dkoli jej\u00ED senzitivita je ni\u017E\u0161\u00ED ne\u017E v p\u0159\u00EDpad\u011B stanoven\u00ED nestability mikrosatelit\u016F."@cs . "Hereditary nonpolyposis; hMLH1 gene-mutations; hMSH2 gene-mutations; hMLH1/hMSH2 protein-detection; microsatellite instability"@en . "P(NC6741)" . "\u010Cu\u0159\u00EDk, Romuald" . . "Palas, Josef" . "51" . "RIV/61989592:15110/04:00006102!RIV09-MZ0-15110___" . . "Dvo\u0159\u00E1\u010Dkov\u00E1, Jana" . . "Defects in DNA mismatch repair system are involved in carcinogenesis of sporadic and inherited human cancers. We assessed the feasibility of using immunohistochemistry to detect tumors with DNA mismatch repair deficiency. We analyzed 81 samples (74 colon cancers (CC), 1 colon dysplasia and 6 extracolonic cancers) for hMLH1 and hMSH2 protein expression, microsatellite instability (MSI) and/or mutational analysis." . "Novotn\u00FD, J." . . . "Neoplasma" . . . "Kol\u00E1\u0159, Zden\u011Bk" . . "Immunohistochemical detection of the hMLH1 a hMSH2 proteins in hereditary non-polyposis colon cancer and sporadic colon cancer" . . . . "RIV/61989592:15110/04:00006102" . "Navr\u00E1tilov\u00E1, M." . "Imunohistochemick\u00E1 detekce hMLH1 a hMSH2 protein\u016F u heredit\u00E1rn\u00EDch nepolyp\u00F3zn\u00EDch a sporadick\u00FDch karcinom\u016F tlust\u00E9ho st\u0159eva"@cs . . "Immunohistochemical detection of the hMLH1 a hMSH2 proteins in hereditary non-polyposis colon cancer and sporadic colon cancer" . "15110" . . "3"^^ . "10"^^ .