"P(NH6611)" . "Vliv estrogen-progestinov\u00E9 substituce na expresi estrogenov\u00FDch a progesteronov\u00FDch receptor\u016F a apopt\u00F3zu v lidsk\u00E9m endometriu"@cs . . . "1335-8421" . . "SK - Slovensk\u00E1 republika" . . . "5"^^ . "4" . "THE IMPACT OF ORAL ESTRADIOL AND PROGESTERONE SUBSTITUTION ON ESTROGEN AND PROGESTERONE RECEPTORS EXPRESSION AND APOPTOSIS IN HUMAN ENDOMETRIUM" . "22-28" . "Kub\u00EDnyiov\u00E1, Michaela" . "7"^^ . "[6F5CF0E202F7]" . "Kr\u0161kov\u00E1, Milena" . "567386" . "THE IMPACT OF ORAL ESTRADIOL AND PROGESTERONE SUBSTITUTION ON ESTROGEN AND PROGESTERONE RECEPTORS EXPRESSION AND APOPTOSIS IN HUMAN ENDOMETRIUM"@en . . . "Vliv estrogen-progestinov\u00E9 substituce na expresi estrogenov\u00FDch a progesteronov\u00FDch receptor\u016F a apopt\u00F3zu v lidsk\u00E9m endometriu"@cs . . "RIV/61989592:15110/04:00002040!RIV06-MZ0-15110___" . . "B\u0159ezinov\u00E1, Jana" . "THE IMPACT OF ORAL ESTRADIOL AND PROGESTERONE SUBSTITUTION ON ESTROGEN AND PROGESTERONE RECEPTORS EXPRESSION AND APOPTOSIS IN HUMAN ENDOMETRIUM"@en . "2" . . . "Oborn\u00E1, Ivana" . "Havelka, Pavel" . "Fingerov\u00E1, Helena" . "Lichnovsk\u00FD, V\u00E1clav" . . "15110" . "Exogenn\u00ED hormon\u00E1ln\u00ED manipulace m\u016F\u017Ee m\u00EDt vliv na zm\u011Bnu fyziologick\u00E9 cyklick\u00E9 struktury d\u011Blo\u017En\u00ED sliznice. Tato studie hodnot\u00ED vliv or\u00E1ln\u011B pod\u00E1van\u00E9 n\u00E1hrady estrogen-progesteronu na chov\u00E1n\u00ED receptor\u016F estrogenu a progesteronu a na hladinu apopt\u00F3zy v sekre\u010Dn\u00EDm endometriu nahrazen\u00FDch cykl\u016F v porovn\u00E1n\u00ED s p\u0159irozen\u00FDmi cykly u stejn\u00E9ho pacienta."@cs . . . "Objective: Exogenous hormonal manipulation may alter physiological cyclic pattern of endometrium. This article evaluates the effect of oral estrogen-progesterone substitution on the expression of estrogen and progesterone receptors and the level of apoptosis in the secretory endometrium of substituted cycles by comparison with natural cycles in the same patient.Methods: Serum levels of estradiol (E2), SHBG and progesterone (P) were determined and bioptic samples of endometrium were taken on the 5th and 7th day of luteal phase in 26 infertile women who entered the assisted reproduction program first in a spontaneous and later in an estrogen-progestagen substituted cycle. E and P receptors (ER and PR) were estimated by immunostaining and image analysis in stroma and glandular epithelium. The level of apoptosis was evaluated by the TUNEL assay. Wilcoxon matched-pairs test was used for the statistical analysis of data.Results: The mean serum levels of E2, SHBG and P were higher in substituted cycles;" . . . . . . . "estradiol; progesterone; hormonal substitution; apoptosis; steroid receptors"@en . . "7"^^ . "THE IMPACT OF ORAL ESTRADIOL AND PROGESTERONE SUBSTITUTION ON ESTROGEN AND PROGESTERONE RECEPTORS EXPRESSION AND APOPTOSIS IN HUMAN ENDOMETRIUM" . "RIV/61989592:15110/04:00002040" . "Acta Medica Martiniana" . "Objective: Exogenous hormonal manipulation may alter physiological cyclic pattern of endometrium. This article evaluates the effect of oral estrogen-progesterone substitution on the expression of estrogen and progesterone receptors and the level of apoptosis in the secretory endometrium of substituted cycles by comparison with natural cycles in the same patient.Methods: Serum levels of estradiol (E2), SHBG and progesterone (P) were determined and bioptic samples of endometrium were taken on the 5th and 7th day of luteal phase in 26 infertile women who entered the assisted reproduction program first in a spontaneous and later in an estrogen-progestagen substituted cycle. E and P receptors (ER and PR) were estimated by immunostaining and image analysis in stroma and glandular epithelium. The level of apoptosis was evaluated by the TUNEL assay. Wilcoxon matched-pairs test was used for the statistical analysis of data.Results: The mean serum levels of E2, SHBG and P were higher in substituted cycles;"@en .