"CZ - \u010Cesk\u00E1 republika" . "In last few years, numerous groups of proteins participating in the regulation of cell proliferation, differentiation and death during ontogenesis have been described. In this study we compared the occurrence of Bcl-2, p53 and myc protein families with the level of proliferative activity and apoptosis during development of duodenal epithelium. Paraffin embedded tissues of eight human embryos and foetuses aged from the 6th -18th week of IUD were used. For the detection of apoptotic cells the TUNEL method was performed, the proliferative marker PCNA and all the proteins studied were detected by means of indirect three-step immunohistochemical method.In the 6th and 8th week of intrauterine development we observed isolated TUNEL positive epithelial cells only and this was accompanied by the disperse presence of PCNA as well as by all the studied proteins: Bcl-2, Bax, Bcl-XL, c-myc, N-myc, p53, p63 and p73. In the early foetal period of duodenal development we registered changes in PCNA and TUNEL positiv"@en . . . "15110" . . . . "577361" . "In last few years, numerous groups of proteins participating in the regulation of cell proliferation, differentiation and death during ontogenesis have been described. In this study we compared the occurrence of Bcl-2, p53 and myc protein families with the level of proliferative activity and apoptosis during development of duodenal epithelium. Paraffin embedded tissues of eight human embryos and foetuses aged from the 6th -18th week of IUD were used. For the detection of apoptotic cells the TUNEL method was performed, the proliferative marker PCNA and all the proteins studied were detected by means of indirect three-step immunohistochemical method.In the 6th and 8th week of intrauterine development we observed isolated TUNEL positive epithelial cells only and this was accompanied by the disperse presence of PCNA as well as by all the studied proteins: Bcl-2, Bax, Bcl-XL, c-myc, N-myc, p53, p63 and p73. In the early foetal period of duodenal development we registered changes in PCNA and TUNEL positiv" . . "The occurrence of c-myc, p53 and Bcl-2 family proteins in the early phase of development of duodenal epithelium"@en . "2"^^ . "4"^^ . . "Erd\u00F6sov\u00E1, B\u011Bla" . . "The occurrence of c-myc, p53 and Bcl-2 family proteins in the early phase of development of duodenal epithelium" . . "Holinka, M." . "The occurrence of c-myc, p53 and Bcl-2 family proteins in the early phase of development of duodenal epithelium"@en . "Z(MSM 151100001)" . "[6ABB382A27AB]" . "2" . . . "229-232" . "The occurrence of c-myc, p53 and Bcl-2 family proteins in the early phase of development of duodenal epithelium" . "Vrchoveck\u00FD, J." . "Kylarov\u00E1, Dana" . "V\u00FDskyt protein\u016F rodiny c-myc, p53 a Bcl-2 v \u010Dasn\u00FDch f\u00E1z\u00EDch v\u00FDvoje epitelu duodena."@cs . "RIV/61989592:15110/04:00001965" . . "Bcl-2 family; p53 family; myc; apoptosis; embryo; duodenum"@en . . "V\u00FDskyt protein\u016F rodiny c-myc, p53 a Bcl-2 v \u010Dasn\u00FDch f\u00E1z\u00EDch v\u00FDvoje epitelu duodena."@cs . "RIV/61989592:15110/04:00001965!RIV06-MSM-15110___" . . "V posledn\u00EDch letech bylo pops\u00E1no n\u011Bkolik skupin protein\u016F zasahuj\u00EDc\u00EDch do regulace bun\u011B\u010Dn\u00E9 proliferace , diferenciace a bun\u011B\u010Dn\u00E9 smrti b\u011Bhem ontogeneze. V na\u0161\u00ED studii jsme srovn\u00E1vali v\u00FDskyt n\u011Bkter\u00FDch protein\u016F p\u0159in\u00E1le\u017Eej\u00EDc\u00EDch k Bcl-2, p53 a myc rodin\u00E1m s prolifera\u010Dn\u00ED aktivitou a \u00FArovn\u00ED apopt\u00F3zy b\u011Bhem v\u00FDvoje epitelu lidsk\u00E9ho duodena."@cs . . . "1213-8118" . "Biomedical Papers" . . . "148" . . "4"^^ .