"Modriansk\u00FD, Martin" . . . . "The human glucocorticoid receptor (hGR) plays a pivotal role in cellular processes such as development, differentiation, homeostasis, immune response and in regulation of xenobiotic metabolism. It has been demonstrated recently that colchicine inhibits hGR transcriptional activity in primary cultures of human hepatocytes by a mechanism involving impairment of hGR nucleo-cytoplasmic shuttling. In the present work, we investigated the role of the nuclear factor kappa B (NFkappaB) and c-jun-N-terminal kinase (JNK), the functional hGR antagonists, in this process. We found that microtubule disarray caused by colchicine, vincristine or nocodazole does not activate NFkappaB in human hepatocytes as revealed by p50 and p65 subunits nuclear translocation. On the other hand, we demonstrate that JNK mediates hGR transcriptional inhibition by microtubules disarray, because a specific inhibitor of JNK, 1,9-pyrazoloanthrone (SP600125), partially blocked tyrosine aminotransferase mRNA suppression due to colchicine t" . "Microtubule disarray in primary cultures of human hepatocytes inhibits transcriptional activity of the glucocorticoid receptor via activation of c-jun N-terminal kinase" . "4"^^ . "573552" . "1213-8118" . "135-139" . "5"^^ . "[6DB886560478]" . "Biomedical Papers" . "Microtubule disarray in primary cultures of human hepatocytes inhibits transcriptional activity of the glucocorticoid receptor via activation of c-jun N-terminal kinase" . . . . . "3"^^ . . "Lidsk\u00FD glukokortikoidn\u00ED receptor (hGR) hraje st\u011B\u017Eejn\u00ED \u00FAlohu v bun\u011B\u010Dn\u00FDch procesech jakoje v\u00FDvoj, diferenciace, homeost\u00E1za, imunitn\u00ED odpov\u011B\u010F a regulace metabolismu xenobiotik. Ned\u00E1vno bylo prok\u00E1z\u00E1no, \u017Ee kolchicin inhibuje transkrip\u010Dn\u00ED aktivitu hGR v prim\u00E1rn\u00EDch kultur\u00E1ch lidsk\u00FDch hepatocyt\u016F mechanismem zahrnuj\u00EDc\u00EDm naru\u0161en\u00ED jadern\u00E9 translokace hGR. V t\u00E9to pr\u00E1ci jsme zkoumali \u00FAlohu jadern\u00E9ho faktoru kappa B NFkB a Lidsk\u00FD glukokortikoidn\u00ED receptor (hGR) hraje st\u011B\u017Eejn\u00ED \u00FAlohu v bun\u011B\u010Dn\u00FDch procesech jakoje v\u00FDvoj, diferenciace, homeost\u00E1za, imunitn\u00ED odpov\u011B\u010F a regulace metabolismu xenobiotik. Ned\u00E1vno bylo prok\u00E1z\u00E1no, \u017Ee kolchicin inhibuje transkrip\u010Dn\u00ED aktivitu hGR v prim\u00E1rn\u00EDch kultur\u00E1ch lidsk\u00FDch hepatocyt\u016F mechanismem zahrnuj\u00EDc\u00EDm naru\u0161en\u00ED jadern\u00E9 translokace hGR. V t\u00E9to pr\u00E1ci jsme zkoumali \u00FAlohu jadern\u00E9ho faktoru kappa B NFkB a c-jun-N-termin\u00E1ln\u00ED kinasy (JNK), funk\u010Dn\u00EDho antagonisty hGR, v tomto procesu. Zjistili jsme, \u017Ee rozru\u0161en\u00ED mikrotubul\u016F kolchicinem, vinkristinem nebo nokodazolem neaktivuje NFkB v lidsk\u00FDch hep"@cs . "148" . . . . "2" . "Microtubule disarray in primary cultures of human hepatocytes inhibits transcriptional activity of the glucocorticoid receptor via activation of c-jun N-terminal kinase"@en . . "CZ - \u010Cesk\u00E1 republika" . . "P(GP303/04/P074), Z(MSM 151100003)" . "Dvo\u0159\u00E1k, Zden\u011Bk" . . "Rozru\u0161en\u00ED mikrotubul\u016F v prim\u00E1rn\u00EDch kultur\u00E1ch lidsk\u00FDch hepatocyt\u016F inhibuje transkrip\u010Dn\u00ED aktivitu glukokortikoidn\u00EDho receptoru prost\u0159ednictv\u00EDm aktivace c-jun-N-termin\u00E1ln\u00ED kinasy"@cs . "Maurel, Patrick" . . "RIV/61989592:15110/04:00001776!RIV06-MSM-15110___" . . . "The human glucocorticoid receptor (hGR) plays a pivotal role in cellular processes such as development, differentiation, homeostasis, immune response and in regulation of xenobiotic metabolism. It has been demonstrated recently that colchicine inhibits hGR transcriptional activity in primary cultures of human hepatocytes by a mechanism involving impairment of hGR nucleo-cytoplasmic shuttling. In the present work, we investigated the role of the nuclear factor kappa B (NFkappaB) and c-jun-N-terminal kinase (JNK), the functional hGR antagonists, in this process. We found that microtubule disarray caused by colchicine, vincristine or nocodazole does not activate NFkappaB in human hepatocytes as revealed by p50 and p65 subunits nuclear translocation. On the other hand, we demonstrate that JNK mediates hGR transcriptional inhibition by microtubules disarray, because a specific inhibitor of JNK, 1,9-pyrazoloanthrone (SP600125), partially blocked tyrosine aminotransferase mRNA suppression due to colchicine t"@en . . "Microtubules; glucocorticoid receptor; c-jun N-terminal kinase; human hepatocytes; NFkB; colchicine"@en . . "Ulrichov\u00E1, Jitka" . "15110" . "Rozru\u0161en\u00ED mikrotubul\u016F v prim\u00E1rn\u00EDch kultur\u00E1ch lidsk\u00FDch hepatocyt\u016F inhibuje transkrip\u010Dn\u00ED aktivitu glukokortikoidn\u00EDho receptoru prost\u0159ednictv\u00EDm aktivace c-jun-N-termin\u00E1ln\u00ED kinasy"@cs . . "Microtubule disarray in primary cultures of human hepatocytes inhibits transcriptional activity of the glucocorticoid receptor via activation of c-jun N-terminal kinase"@en . . . "RIV/61989592:15110/04:00001776" .