. . . "2"^^ . "Silymarin;flavonoid;flavonolignan;antioxidant;radical scavenger"@en . "Oxidised derivatives of silybin and their antiradical and antioxidant activity"@en . "5677-5687" . "Karboxylov\u00E9 kyseliny odvozen\u00E9 od silybinu a 2,3-dehydrosilybinu byly p\u0159ipraveny selektivn\u00ED oxidac\u00ED p\u016Fvodn\u00EDch l\u00E1tek a nov\u00E1 levn\u011Bj\u0161\u00ED metoda pro p\u0159\u00EDpravu 2,3-dehydrosylibinu z silybinu byla p\u0159ipravena a optimalizov\u00E1na. Antioxida\u010Dn\u00ED vlastnosti obou v\u00FD\u0161e zm\u00EDn\u011Bn\u00FDch l\u00E1tek a vedlej\u0161\u00EDho produktu oxidace silybinu byly zji\u0161t\u011Bny cyklickou voltametri\u00ED, zh\u00E1\u0161en\u00EDm voln\u00E9ho radik\u00E1lu (DPPH, superoxidu) a inhibic\u00ED peroxidace lipid\u016F mikrosom\u00E1ln\u00EDch membr\u00E1m. Dehydrogenace vazby C2-C3 flavonolignan\u016F (silybinu vs 2,3-dehydrosilybinu; silybinov\u00E9 kyseliny vs 2,3-dehydrosilybinov\u00E9 kyseliny) v\u00FDrazn\u011B zv\u00FD\u0161ila antioxida\u010Dn\u00ED vlastnosti (analogicky jako u flavonoid\u016F taxifolin vs kvercetin). Antioxida\u010Dn\u00ED vlastnosti 2,3-dehydrosilybinu byly lep\u0161\u00ED ne\u017E u silybinu, ale jeho rozpustnost ve vodn\u00E9m prost\u0159ed\u00ED je p\u0159\u00EDli\u0161 n\u00EDzk\u00E1. 2,3-dehydrosilybinov\u00E1 kyselina je v\u0161ak rozpustn\u011Bj\u0161\u00ED deriv\u00E1t s lep\u0161\u00EDmi antioxida\u010Dn\u00EDmi vlastnostmi a schopnost\u00ED zh\u00E1\u0161et radik\u00E1ly ne\u017E silybin."@cs . "578690" . . . . "K\u0159en, Vladim\u00EDr" . "Walterov\u00E1, Daniela" . "12" . "Ga\u017E\u00E1k, R." . "Carboxylic acids derived from silybin (1) and 2,3-dehydrosilybin (2) with improved water solubility were prepared by selective oxidation of parent compounds and a new inexpensive method for preparation of 2,3-dehydrosilybin from silybin was developed and optimised. The antioxidative properties of the above-mentioned compounds and of side product 3a from oxidation of compound 1 were determined by cyclic voltammetry, free radical scavenging (DPPH, superoxide) assays, and by inhibition of in vitro generated liver microsomal lipid peroxidation. Dehydrogenation at C((2))-C((3)) in flavonolignans (silybin vs 2,3-dehydrosilybin; silybinic acid vs 2,3-dehydrosilybinic acid) strongly improved antioxidative properties (analogously as in flavonoids taxifolin vs quercetin). Thus, in antioxidative properties, dehydrosilybin was superior to silybin by one order, but its water solubility is too low for application in aqueous milieu. On the other hand, 2,3-dehydrosilybinic acid is a fairly soluble derivative with ant"@en . . "7"^^ . "0968-0896" . "Carboxylic acids derived from silybin (1) and 2,3-dehydrosilybin (2) with improved water solubility were prepared by selective oxidation of parent compounds and a new inexpensive method for preparation of 2,3-dehydrosilybin from silybin was developed and optimised. The antioxidative properties of the above-mentioned compounds and of side product 3a from oxidation of compound 1 were determined by cyclic voltammetry, free radical scavenging (DPPH, superoxide) assays, and by inhibition of in vitro generated liver microsomal lipid peroxidation. Dehydrogenation at C((2))-C((3)) in flavonolignans (silybin vs 2,3-dehydrosilybin; silybinic acid vs 2,3-dehydrosilybinic acid) strongly improved antioxidative properties (analogously as in flavonoids taxifolin vs quercetin). Thus, in antioxidative properties, dehydrosilybin was superior to silybin by one order, but its water solubility is too low for application in aqueous milieu. On the other hand, 2,3-dehydrosilybinic acid is a fairly soluble derivative with ant" . . "Psotov\u00E1, Jitka" . "21" . "P(GA303/02/1097)" . "Oxidovan\u00E9 deriv\u00E1ty silybinu a jejich antiradik\u00E1lov\u00E1 a antioxida\u010Dn\u00ED aktivita"@cs . "11"^^ . "Sedmera, Vladim\u00EDr" . "[5C2A73EBAE3B]" . "Oxidovan\u00E9 deriv\u00E1ty silybinu a jejich antiradik\u00E1lov\u00E1 a antioxida\u010Dn\u00ED aktivita"@cs . "P\u0159ikrylov\u00E1, V\u011Bra" . "RIV/61989592:15110/04:00000860" . . . . . "Bioorganic & Medicinal Chemistry" . . "Oxidised derivatives of silybin and their antiradical and antioxidant activity" . . "15110" . "NL - Nizozemsko" . "Oxidised derivatives of silybin and their antiradical and antioxidant activity" . . . "Svobodov\u00E1, Alena" . . "RIV/61989592:15110/04:00000860!RIV/2005/GA0/151105/N" . . "Oxidised derivatives of silybin and their antiradical and antioxidant activity"@en .