. . "610059" . . . . "Interspecies differences in glycosidation potential in mammalian tissues represent a factor contributing to ambiguity when endobiotic and/or xenobiotic metabolic pathways are extrapolated from animals to man. Using the TLC/autoradiographic technique, we conducted an in vitro investigation involving mouse, rat, monkey, as well as human liver and kidney microsomes to evaluate their glycoconjugation potential towards (3)H-labeled, purine-derived selective inhibitors of cyclin-dependent kinases such as olomoucine, bohemine, roscovitine, 6-(2-hydroxybenzyl)amino-2-(1-hydroxymethyl-2-methylpropyl)amino-9-isopropylpurine (compound A-4), and 6-(3-hydroxybenzyl)amino-2-[(1(R/S)-hydroxymethyl)propyl]amino-9-isopropylpurine (compound A-5) as aglycones. Principally, this study confirmed the aliphatic hydroxyl group of olomoucine-type inhibitors as a relatively suitable target for glucuronide, glucoside, xyloside, galactoside, and/or N-acetylaminoglucoside conjugation. Of the tissues examined, only the mouse micro" . . . "In vitro glycosidation potential towards Olomoucine - type cyclin-dependent kinase inhibitors in rodent and primate microsomes"@en . "6"^^ . . . "14"^^ . "Belejov\u00E1, Marie" . "Michnov\u00E1, K." . . . "8"^^ . "Mezidruhov\u00E9 rozd\u00EDly v glykosidaci v sav\u010D\u00EDch tk\u00E1n\u00EDch ukazuj\u00ED na nejednozna\u010Dnosti p\u0159i extrapolaci endobiotick\u00FDch a xenobiotick\u00FDch cest ze zv\u00ED\u0159at na \u010Dlov\u011Bka."@cs . "Glykosidace in vitro za \u00FA\u010Delem inhibitoru cyklin dependentn\u00ED kin\u00E1zy olomoucinov\u00E9ho typu a v mikrosomech hlodavc\u016F a prim\u00E1t\u016F"@cs . "\u010Cervenkov\u00E1, Kate\u0159ina" . "4" . "0862-8408" . "15110" . "In vitro glycosidation potential towards Olomoucine - type cyclin-dependent kinase inhibitors in rodent and primate microsomes" . . . "Physiological Research (print)" . . "Michal\u00EDkov\u00E1, K." . . . . . . "\u0160\u00FArov\u00E1, I." . "Hanu\u0161, Jan" . "Chmela, Zden\u011Bk" . "Brejcha, A." . "CZ - \u010Cesk\u00E1 republika" . "[C22FE7582D7E]" . "Vesel\u00FD, Jaroslav" . . "Fuksov\u00E1, Kv\u011Btoslava" . . . "glycosidation; mouse; rat; monkey; human; CDK inhibitors"@en . "P(GA301/02/0475), P(OC B17.20), V, Z(MSM 151100001)" . "Riegrov\u00E1, Dagmar" . "Interspecies differences in glycosidation potential in mammalian tissues represent a factor contributing to ambiguity when endobiotic and/or xenobiotic metabolic pathways are extrapolated from animals to man. Using the TLC/autoradiographic technique, we conducted an in vitro investigation involving mouse, rat, monkey, as well as human liver and kidney microsomes to evaluate their glycoconjugation potential towards (3)H-labeled, purine-derived selective inhibitors of cyclin-dependent kinases such as olomoucine, bohemine, roscovitine, 6-(2-hydroxybenzyl)amino-2-(1-hydroxymethyl-2-methylpropyl)amino-9-isopropylpurine (compound A-4), and 6-(3-hydroxybenzyl)amino-2-[(1(R/S)-hydroxymethyl)propyl]amino-9-isopropylpurine (compound A-5) as aglycones. Principally, this study confirmed the aliphatic hydroxyl group of olomoucine-type inhibitors as a relatively suitable target for glucuronide, glucoside, xyloside, galactoside, and/or N-acetylaminoglucoside conjugation. Of the tissues examined, only the mouse micro"@en . "In vitro glycosidation potential towards Olomoucine - type cyclin-dependent kinase inhibitors in rodent and primate microsomes"@en . "RIV/61989592:15110/03:00007270" . . . "\u010Cern\u00FD, B." . "Rypka, Miroslav" . "Havl\u00ED\u010Dek, Libor" . "RIV/61989592:15110/03:00007270!RIV09-MSM-15110___" . "Glykosidace in vitro za \u00FA\u010Delem inhibitoru cyklin dependentn\u00ED kin\u00E1zy olomoucinov\u00E9ho typu a v mikrosomech hlodavc\u016F a prim\u00E1t\u016F"@cs . "In vitro glycosidation potential towards Olomoucine - type cyclin-dependent kinase inhibitors in rodent and primate microsomes" . . . "52" . .