"1" . . . "Anti-/pro-oxidant effects of phenolic compounds in cells; are colchicine metabolites chain-breaking antioxidants?"@en . "Tyurina, Yulia" . . "[877EA3A9B1E6]" . "Matsura, Tatsuya" . . "Shvedova, Anna" . "Lipid oxidation; antioxidant; radical scavenger; colchicine metabolites; parinaric acid; etoposide"@en . . "RIV/61989592:15110/02:00006970!RIV09-GA0-15110___" . . . "Effective scavenging of reactive radicals and low reactivity of generated secondary antioxidant radicals towards vital intracellular components are two critical requirements for a chain-breaking antioxidant. Tubulin-binding properties aside, colchicine metabolites remain largely untested for other possible biological activities, including antioxidant activity. Mourelle et al. [Life Sci. 45 (1989) 891] proposed that colchiceine (EIN) acts as an antioxidant and protective agent against lipid peroxidation in a rat model of liver injury. Since EIN as well as two other colchicine metabolites, 2-demethylcolchicine (2DM) and 3-demethylcolchicine (3DM), possess a hydroxy-group on their carbon ring that could participate in radical scavenging, we tested whether they can act as chain-breaking antioxidants. Using our fluorescence-HPLC assay with metabolically incorporated oxidation-sensitive cis-parinaric acid (PnA) we studied the effects of colchicine metabolites on peroxidation of different classes of membrane"@en . . "NL - Nizozemsko" . . "Effective scavenging of reactive radicals and low reactivity of generated secondary antioxidant radicals towards vital intracellular components are two critical requirements for a chain-breaking antioxidant. Tubulin-binding properties aside, colchicine metabolites remain largely untested for other possible biological activities, including antioxidant activity. Mourelle et al. [Life Sci. 45 (1989) 891] proposed that colchiceine (EIN) acts as an antioxidant and protective agent against lipid peroxidation in a rat model of liver injury. Since EIN as well as two other colchicine metabolites, 2-demethylcolchicine (2DM) and 3-demethylcolchicine (3DM), possess a hydroxy-group on their carbon ring that could participate in radical scavenging, we tested whether they can act as chain-breaking antioxidants. Using our fluorescence-HPLC assay with metabolically incorporated oxidation-sensitive cis-parinaric acid (PnA) we studied the effects of colchicine metabolites on peroxidation of different classes of membrane" . "Kagan, Valerian E." . . . "Anti/pro-oxida\u010Dn\u00ED \u00FA\u010Dinky fenolick\u00FDch slou\u010Denin v bu\u0148k\u00E1ch: jsou metabolity kolchicinu \u0159et\u011Bzec ru\u0161\u00EDc\u00EDmi antioxidanty?"@cs . . "Anti/pro-oxida\u010Dn\u00ED \u00FA\u010Dinky fenolick\u00FDch slou\u010Denin v bu\u0148k\u00E1ch: jsou metabolity kolchicinu \u0159et\u011Bzec ru\u0161\u00EDc\u00EDmi antioxidanty?"@cs . "P(GA303/99/P002)" . . "Modriansk\u00FD, Martin" . "7"^^ . . . "Yalowich, Jack C." . "Anti-/pro-oxidant effects of phenolic compounds in cells; are colchicine metabolites chain-breaking antioxidants?" . "13"^^ . . "0300-483X" . "RIV/61989592:15110/02:00006970" . "638595" . "\u00DA\u010Dinn\u00E9 vychyt\u00E1v\u00E1n\u00ED reaktivn\u00EDch radik\u00E1l\u016F a n\u00EDzk\u00E1 reaktivita vznikl\u00FDch sekund\u00E1rn\u00EDch antioxidant\u016F-radik\u00E1l\u016F v\u016F\u010Di d\u016Fle\u017Eit\u00FDm intracelul\u00E1rn\u00EDm komponent\u00E1m jsou dv\u011B d\u016Fle\u017Eit\u00E1 krit\u00E9ria pro \u0159et\u011Bzec ru\u0161\u00EDc\u00ED antioxidant. Nehled\u011B na vlastnosti vazby na tubulin, metabolity kolchicinu nebyly testov\u00E1ny na jin\u00E9 biologick\u00E9 aktivity, v\u010Detn\u011B antioxida\u010Dn\u00ED aktivity. Proto\u017Ee kolchicein (EIN), stejn\u011B jako dal\u0161\u00ED dva metabolity kolchicinu, 2-demethylkolchicin (2-DM) a 3-demethylkolchicin (3-DM), maj\u00ED hydroxy skupinu, kter\u00E1 se m\u016F\u017Ee pod\u00EDlet na vychyt\u00E1v\u00E1n\u00ED radik\u00E1l\u016F, testovali jsme, zda mohou b\u00FDt \u0159et\u011Bzec ru\u0161\u00EDc\u00EDmi antioxidanty. \u017D\u00E1dn\u00FD z testovan\u00FDch metabolit\u016F kolchicinu v rozsahu koncentrac\u00ED od 1 do 100 mikromol\u00E1rn\u00ED nebyl schopen chr\u00E1nit fofolipidy proti peroxidaci vyvolan\u00E9 bu\u010F azo-slou\u010Deninami nebo reakcemi katalyzovan\u00FDmi myeloperoxidasou v p\u0159\u00EDtomnosti peroxidu vod\u00EDku. Av\u0161ak metabolity vykazovaly koncentra\u010Dn\u011B z\u00E1vislou depleci glutathionu, co\u017E p\u0159ipom\u00EDn\u00E1 chov\u00E1n\u00ED etoposidu. Experimenty s elektronovou spin resonanc\u00ED (ESR) demonstrovaly, \u017E"@cs . "Tyurin, Vladimir" . "15110" . "Anti-/pro-oxidant effects of phenolic compounds in cells; are colchicine metabolites chain-breaking antioxidants?" . . "Anti-/pro-oxidant effects of phenolic compounds in cells; are colchicine metabolites chain-breaking antioxidants?"@en . "1"^^ . "177" . "Toxicology" . .