. "4"^^ . "638584" . "Walterov\u00E1, Daniela" . "Ulrichov\u00E1, Jitka" . "Antioxida\u010Dn\u00ED vlastnosti silybinov\u00FDch glykosid\u016F"@cs . "Antioxidant properties of silybin glykosides" . "Nov\u00E9 rozpustn\u00E9 deriv\u00E1ty hepatoprotektivn\u00EDho flavonolignanu silybinu (galaktosid, glukosid, laktosid a maltosid) byly studov\u00E1ny pro svoje vlastnosti lapa\u010D\u016F radik\u00E1l\u016F a sni\u017Eov\u00E1n\u00ED m\u00EDry lipoperoxidace. Ve shod\u011B s v\u00FDsledky cyklick\u00E9 volumetrie jsou glykosidy silybinu slab\u0161\u00EDmi donory elektron\u016F ne\u017E aglykon, ale na modelech vychyt\u00E1v\u00E1n\u00ED radik\u00E1l\u016F (metody DPPH a TEAC) byly glykosidy lep\u0161\u00EDmi lapa\u010Di radik\u00E1l\u016F ne\u017E samotn\u00FD silybin. Glykosidy vykazovaly vy\u0161\u0161\u00ED ochranu proti terc-butylhydroperoxidem vyvol\u00E1vanou lipoperoxidaci potkan\u00EDch jatern\u00EDch mitochondri\u00E1ln\u00EDch membr\u00E1n, d\u00E1le tak\u00E9 l\u00E9pe chr\u00E1nily proti toxick\u00E9mu \u00FA\u010Dinku terc-butylhydroperoxidu na modelech potkan\u00EDch erytrocyt\u016F a prim\u00E1rn\u00EDch kultur potkan\u00EDch hepatocyt\u016F ve srovn\u00E1n\u00ED se silybinem. Glykosilace silybinu sni\u017Eovala vlastn\u00ED toxicitu aglykonu, pozorovanou na potkan\u00EDch hepatocytech p\u0159i del\u0161\u00EDch intervalech inkubace. V\u00FDsledky ukazuj\u00ED, \u017Ee glykosidy silybinu, rozpustn\u00E9 deriv\u00E1ty silybinu, jsou vhodn\u00E9 pro dal\u0161\u00ED studie a mohou m\u00EDt terapeutick\u00FD potenci\u00E1l."@cs . . "15110" . . "Kosina, Pavel" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "RIV/61989592:15110/02:00006953!RIV09-MSM-15110___" . "0951-418X" . . . "6"^^ . . "K\u0159en, Vladim\u00EDr" . . "Antioxidant properties of silybin glykosides" . "16" . "Phytotherapy Research" . . "New soluble derivatives of the hepatoprotective flavonolignan silybin (1), namely silybin galactoside (2), glucoside (3), lactoside (4) and maltoside (5) were investigated for their radical scavenging and antilipoperoxidation properties. According to cyclic voltammetry the results show that glycosides are weaker electron donors than silybin, although it was of interest that they were found to be more potent scavengers of the 1,1-diphenyl-2-picrylhydrazyl and the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)-derived radicals. The glycosides (2)-(5) were more efficient than silybin in preventing tert-butylhydroperoxide-induced lipoperoxidation of rat liver mitochondrial membranes. Furthermore, glycosides (2)-(5) were significantly more cytoprotective than silybin in tert-butylhydroperoxide-damaged rat erythrocytes and primary hepatocyte cultures. Glycosylation of silybin substantially reduced its toxic effects in primary cultured hepatocytes observed during prolonged incubation. These res" . "7"^^ . "Grambal, Franti\u0161ek" . "Antioxida\u010Dn\u00ED vlastnosti silybinov\u00FDch glykosid\u016F"@cs . "RIV/61989592:15110/02:00006953" . "Antioxidant properties of silybin glykosides"@en . . "P(GA303/98/0414), Z(MSM 151100003)" . "[0650CAD8B321]" . "1" . "New soluble derivatives of the hepatoprotective flavonolignan silybin (1), namely silybin galactoside (2), glucoside (3), lactoside (4) and maltoside (5) were investigated for their radical scavenging and antilipoperoxidation properties. According to cyclic voltammetry the results show that glycosides are weaker electron donors than silybin, although it was of interest that they were found to be more potent scavengers of the 1,1-diphenyl-2-picrylhydrazyl and the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)-derived radicals. The glycosides (2)-(5) were more efficient than silybin in preventing tert-butylhydroperoxide-induced lipoperoxidation of rat liver mitochondrial membranes. Furthermore, glycosides (2)-(5) were significantly more cytoprotective than silybin in tert-butylhydroperoxide-damaged rat erythrocytes and primary hepatocyte cultures. Glycosylation of silybin substantially reduced its toxic effects in primary cultured hepatocytes observed during prolonged incubation. These res"@en . "Antioxidant properties of silybin glykosides"@en . . . . "Silybin glykosides; Radical scavenging; Lipoperoxidation; Rat hepatocytes"@en . . "Gebhardt, Rolf" . . . . . . . . .