"Influence of silymarin and its flavonolignans on doxorubicin-iron induced lipid peroxidation in rat heart microsomes and mitochondria in comparison with quercetin"@en . . . . . . . "RIV/61989592:15110/02:00006949" . . "Phytotherapy Research" . . . "Influence of silymarin and its flavonolignans on doxorubicin-iron induced lipid peroxidation in rat heart microsomes and mitochondria in comparison with quercetin" . "5"^^ . "Silymarin; silybin; silydianin; silychristin; quercetin; rat heart microsomes; rat heart mitochondria; iron; doxorubicin; lipid peroxidation; DPPH color reduction; peak oxidation potentials."@en . . "Porovn\u00E1n\u00ED vlivu silymarinu a jeho flavonolignan\u016F s kvercetinem na peroxidaci lipid\u016F potkan\u00EDch srde\u010Dn\u00EDch mikrosom\u016F a mitochondri\u00ED"@cs . "Silymarin, extrakt ze semen Silybum marianum a jeho obsahov\u00E9 l\u00E1tky flavonolignany silybin, silydianin a silychristin a flavonol kvercetin sni\u017Eovaly oxida\u010Dn\u00ED po\u0161kozen\u00ED lipid\u016F potkan\u00EDch srde\u010Dn\u00EDch mikrosom\u016F a mitochondri\u00ED, kter\u00E9 bylo zp\u016Fsoben\u00E9 komplexem \u017Eeleza s doxorubicinem. Kvercetin byl v\u00EDce \u00FA\u010Dinn\u00FD ne\u017E silymarin a jeho t\u0159i obsahov\u00E9 slo\u017Eky, jejich\u017E \u00FA\u010Dinek byl srovnateln\u00FD. Schopnost l\u00E1tek zh\u00E1\u0161et radik\u00E1ly byla testov\u00E1na pomoc\u00ED reakce s barevn\u00FDm DPPH a cyklickou volumetri\u00ED, aby byly zji\u0161t\u011Bny jejich antioxida\u010Dn\u00EDch vlastnosti. Na rozd\u00EDl od kvercetinu, silybin, silydianin and silychristin nevytv\u00E1\u0159ely komplexy s ionty \u017Eeleza ve vodn\u00E9m prost\u0159ed\u00ED. V\u00FDsledky nazna\u010Duj\u00ED, \u017Ee silymarin by mohl sni\u017Eovat po\u0161kozen\u00ED potkan\u00EDch srde\u010Dn\u00EDch membr\u00E1n vyvolan\u00E9 doxorubicinem d\u00EDky schopnosti interagovat s voln\u00FDmi radik\u00E1ly."@cs . . "Psotov\u00E1, Jitka" . "Grambal, Franti\u0161ek" . . "15110" . . . "Influence of silymarin and its flavonolignans on doxorubicin-iron induced lipid peroxidation in rat heart microsomes and mitochondria in comparison with quercetin"@en . . . . "Chlop\u010D\u00EDkov\u00E1, \u0160\u00E1rka" . . . . "Silymarin, an extract of Silybum marianum seeds, and the constituent flavonolignans silybin, silydianin and silychristin, as well as the flavonol quercetin, protected rat heart microsomes and mitochondria against iron-dependent doxorubicin induced lipid peroxidation. Quercetin was found to be more potent than either silymarin or its three constituents, whose cytoprotectivity was comparable. The radical scavenging activity of the compounds was investigated using a DPPH colour reduction assay and cyclic voltametry to assess their antioxidant activities. In contrast to quercetin, silybin, silydianin and silychristin did not chelate iron in aqueous solution. The results suggest that silymarin may prevent doxorubicin-mediated damage to rat heart membrane primarily through a free radical scavenging mechanism." . "Porovn\u00E1n\u00ED vlivu silymarinu a jeho flavonolignan\u016F s kvercetinem na peroxidaci lipid\u016F potkan\u00EDch srde\u010Dn\u00EDch mikrosom\u016F a mitochondri\u00ED"@cs . . "648954" . "0951-418X" . . . "RIV/61989592:15110/02:00006949!RIV09-MSM-15110___" . "Silymarin, an extract of Silybum marianum seeds, and the constituent flavonolignans silybin, silydianin and silychristin, as well as the flavonol quercetin, protected rat heart microsomes and mitochondria against iron-dependent doxorubicin induced lipid peroxidation. Quercetin was found to be more potent than either silymarin or its three constituents, whose cytoprotectivity was comparable. The radical scavenging activity of the compounds was investigated using a DPPH colour reduction assay and cyclic voltametry to assess their antioxidant activities. In contrast to quercetin, silybin, silydianin and silychristin did not chelate iron in aqueous solution. The results suggest that silymarin may prevent doxorubicin-mediated damage to rat heart membrane primarily through a free radical scavenging mechanism."@en . . . "P(GA303/97/P081), Z(MSM 151100003)" . "5"^^ . "\u0160im\u00E1nek, Vil\u00EDm" . . . "5"^^ . "1" . "Influence of silymarin and its flavonolignans on doxorubicin-iron induced lipid peroxidation in rat heart microsomes and mitochondria in comparison with quercetin" . "Ulrichov\u00E1, Jitka" . . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "[7818854CFCD1]" . . "16" .