. . . "Guanyliny - nov\u00E1 nad\u011Bjn\u00E1 cesta ve v\u00FDzkumu postprandi\u00E1ln\u00ED natriur\u00E9zy" . "50" . . . "Syst\u00E9mov\u00E1 arteri\u00E1ln\u00ED hypertenze je civiliza\u010Dn\u00ED epidemickou chorobou s 20-25% prevalenc\u00ED v dosp\u011Bl\u00E9 populaci. P\u0159esto\u017Ee na fyziologick\u00E9 \u00FArovni je z\u0159ejm\u00E9, \u017Ee jde o fundament\u00E1ln\u00ED poruchu bilance sol\u00ED a tekutin v t\u011Ble, objas\u0148ov\u00E1n\u00ED molekul\u00E1rn\u00EDch z\u00E1klad\u016F hypertenze je teprve na po\u010D\u00E1tku. U \u010D\u00E1sti hypertenzivn\u00EDch osob je nedostate\u010Dn\u011B vyj\u00E1d\u0159ena tzv. postprandi\u00E1ln\u00ED natriur\u00E9za. Ukazuje se, \u017Ee jednou z d\u016Fle\u017Eit\u00FDch fyziologick\u00FDch odpov\u011Bd\u00ED, kter\u00E9 norm\u00E1ln\u011B zaji\u0161\u0165uj\u00ED rychl\u00E9 vylou\u010Den\u00ED soli p\u0159ijat\u00E9 s potravou, je tvorba tzv. guanylinov\u00FDch peptid\u016F ve st\u0159evn\u00ED sliznici. Guanyliny p\u016Fsob\u00ED parakrinn\u011B a endokrinn\u011B. Integruj\u00ED s guanyl\u00E1tcykl\u00E1zov\u00FDmi receptory bun\u011B\u010Dn\u00FDch membr\u00E1n a tvo\u0159\u00ED p\u00E1te\u0159 nov\u00E9 endokrinn\u00ED osy, kter\u00E1 prost\u0159ednictv\u00EDm cirkuluj\u00EDc\u00EDch guanylin\u016F spojuje st\u0159evo a ledviny. Objev guanylin\u016F slibuje roz\u0161\u00ED\u0159it perspektivy v\u00FDzkumu tzv. s\u016Fl-senzitivn\u00EDch forem hypertenze."@cs . "[23E9511E47B8]" . . . "Syst\u00E9mov\u00E1 arteri\u00E1ln\u00ED hypertenze je civiliza\u010Dn\u00ED epidemickou chorobou s 20-25% prevalenc\u00ED v dosp\u011Bl\u00E9 populaci. P\u0159esto\u017Ee na fyziologick\u00E9 \u00FArovni je z\u0159ejm\u00E9, \u017Ee jde o fundament\u00E1ln\u00ED poruchu bilance sol\u00ED a tekutin v t\u011Ble, objas\u0148ov\u00E1n\u00ED molekul\u00E1rn\u00EDch z\u00E1klad\u016F hypertenze je teprve na po\u010D\u00E1tku. U \u010D\u00E1sti hypertenzivn\u00EDch osob je nedostate\u010Dn\u011B vyj\u00E1d\u0159ena tzv. postprandi\u00E1ln\u00ED natriur\u00E9za. Ukazuje se, \u017Ee jednou z d\u016Fle\u017Eit\u00FDch fyziologick\u00FDch odpov\u011Bd\u00ED, kter\u00E9 norm\u00E1ln\u011B zaji\u0161\u0165uj\u00ED rychl\u00E9 vylou\u010Den\u00ED soli p\u0159ijat\u00E9 s potravou, je tvorba tzv. guanylinov\u00FDch peptid\u016F ve st\u0159evn\u00ED sliznici. Guanyliny p\u016Fsob\u00ED parakrinn\u011B a endokrinn\u011B. Integruj\u00ED s guanyl\u00E1tcykl\u00E1zov\u00FDmi receptory bun\u011B\u010Dn\u00FDch membr\u00E1n a tvo\u0159\u00ED p\u00E1te\u0159 nov\u00E9 endokrinn\u00ED osy, kter\u00E1 prost\u0159ednictv\u00EDm cirkuluj\u00EDc\u00EDch guanylin\u016F spojuje st\u0159evo a ledviny. Objev guanylin\u016F slibuje roz\u0161\u00ED\u0159it perspektivy v\u00FDzkumu tzv. s\u016Fl-senzitivn\u00EDch forem hypertenze." . . "Guanyliny - nov\u00E1 nad\u011Bjn\u00E1 cesta ve v\u00FDzkumu postprandi\u00E1ln\u00ED natriur\u00E9zy"@cs . "CZ - \u010Cesk\u00E1 republika" . "1"^^ . "P(OC B17.20), Z(MSM 151100005)" . "Guanylins - new perspectives in postprandial natriuresis research"@en . "Guanyliny - nov\u00E1 nad\u011Bjn\u00E1 cesta ve v\u00FDzkumu postprandi\u00E1ln\u00ED natriur\u00E9zy" . . "681418" . "guanylin; guanylate cyclase receptors; postprandial natriuresis; hypertension"@en . "1"^^ . "RIV/61989592:15110/01:00007111" . . "7"^^ . . . . "15110" . . "Vesel\u00FD, Jaroslav" . "RIV/61989592:15110/01:00007111!RIV09-MSM-15110___" . "1210-6313" . "More than 20% of adults in industrialized countries display arterial pressure outside the normal physiological range. For most inidividuals, the molecular basis of hypertension remains unknown. In some hypertensive persons, a postprandial natriuretic response, normally elicited by a salty meal, is diminished and contributes to body sodium accumulation and plasma volume expansion. An important physiological mechanism ensuring the increased salt excretion following ingestion of salt is a based on a luminocrine and endocrine secretion of novel small intestinal peptides - guanylins. It can be expected that the emergence of the novel guanylin signaling pathways will energize search for molecular defects causing hypertension."@en . . "2" . "Guanylins - new perspectives in postprandial natriuresis research"@en . . . . "\u010Ceskoslovensk\u00E1 fyziologie" . "Guanyliny - nov\u00E1 nad\u011Bjn\u00E1 cesta ve v\u00FDzkumu postprandi\u00E1ln\u00ED natriur\u00E9zy"@cs .