. "0042-773X" . "CZ - \u010Cesk\u00E1 republika" . . "Vnit\u0159n\u00ED l\u00E9ka\u0159stv\u00ED" . "Chromosomal aberrations are one of the most important prognostic factors in patients with acute myeloid leukemia (AML). This work present analysis of conventional cytogenetic results completed by fluorescence in situ hybridization (FISH) obtained from 105 patients in the time of diagnosis of AML. The median age of patients was 51 years (range 19-79 years), with slight prodominance of women (fmeale to male ratio 1.2 : 1). The evaluated group involved all patients with AML diagnosis, treated by intensive induciton chemotherapy in the Department of Hematolology-oncology, University Hospital, Olomouc during last 4 years with assessable cytogenetic results. Chromosomal changes were found in 63 (60 %) patients. The most often affected chromosomes in succesision of frequency were 8, 17, 7, 5, 11, 15, 16 a 21. Base on found specific and frequent chromosomal changes the patients were divided into 3 prognostic subgroups and the significance of chromosomal aberrations was evaluated. The subgroup of 17 patients w"@en . . "Hlu\u0161\u00ED, Anton\u00EDn" . . "Chromosomov\u00E9 aberace jsou jedn\u00EDm z nejd\u016Fle\u017Eit\u011Bj\u0161\u00EDch prognostick\u00FDch faktor\u016F u nemocn\u00FDch s akutn\u00ED myeloidn\u00ED leuk\u00E9mi\u00ED (AML). V pr\u00E1ci p\u0159edkl\u00E1d\u00E1me anal\u00FDzu v\u00FDsledk\u016F klasick\u00E9 cytogenetiky roz\u0161\u00ED\u0159en\u00FDch o vy\u0161et\u0159en\u00ED metodou fluorescen\u010Dn\u00ED in situ hybridizace (FISH) u 105 nemocn\u00FDch v dob\u011B diagnosy AML. Do sledovan\u00E9ho souboru byli zahrnuti v\u0161ichni nemocn\u00ED s diagn\u00F3zou AML l\u00E9\u010Den\u00ED na Hemato-onkologick\u00E9 klinice FN a LF UP v Olomouci v pr\u016Fb\u011Bhu let 1997- 2000 standardn\u00ED induka\u010Dn\u00ED chemoterapi\u00ED, u nich\u017E byly dostupn\u00E9 hodnotiteln\u00E9 cytogenetick\u00E9 v\u00FDsledky z doby diagn\u00F3zy. Soubor m\u011Bl v\u011Bkov\u00FD medi\u00E1n 51 let (hranice 19-76 let) s m\u00EDrnou p\u0159evahou \u017Een (1,2 : 1). Chromosomov\u00E9 zm\u011Bny byly nalezeny u 63 (60 %) nemocn\u00FDch. Nej\u010Dast\u011Bji byly posti\u017Eeny (v po\u0159ad\u00ED podle \u010Detnosti) chromosomy 8, 17, 7, 5, 11, 15, 16 a 21. Na z\u00E1klad\u011B nalezen\u00FDch specifick\u00FDch a klon\u00E1ln\u00EDch chromosomov\u00FDch zm\u011Bn byl soubor rozd\u011Blen do 3 prognostick\u00FDch podskupin, kter\u00E9 byly statisticky porovn\u00E1ny. Podskupinu 17 nemocn\u00FDch s dobrou progn\u00F3zou tvo\u0159ilo 9 nemocn\u00FDch s akutn\u00ED pro" . . "S1" . . "13"^^ . "9"^^ . "RIV/61989592:15110/01:00006116" . . "Holzerov\u00E1, Milena" . "Raida, Lud\u011Bk" . . . . "Pikalov\u00E1, Zuzana" . "15110" . . "Jedli\u010Dkov\u00E1, Kate\u0159ina" . "7"^^ . "RIV/61989592:15110/01:00006116!RIV09-MZ0-15110___" . . "acute myeloid leukemia; chromosomes; FISH"@en . . . "Prognostick\u00FD v\u00FDznam cytogenetick\u00FDch zm\u011Bn u nemocn\u00FDch s akutn\u00ED myeloidn\u00ED leuk\u00E9mi\u00ED (AML). (Anal\u00FDza v\u00FDsledk\u016F 105 nemocn\u00FDch l\u00E9\u010Den\u00FDch v letech 1997-2000 na Hemato-onkologick\u00E9 klinice FN a LF UP v Olomouci)" . "Sulovsk\u00E1, Ivana" . "[6693DB7756AF]" . "P(NC4699), P(NE6188)" . "Knotkov\u00E1, Renata" . . . "Prognostick\u00FD v\u00FDznam cytogenetick\u00FDch zm\u011Bn u nemocn\u00FDch s akutn\u00ED myeloidn\u00ED leuk\u00E9mi\u00ED (AML). (Anal\u00FDza v\u00FDsledk\u016F 105 nemocn\u00FDch l\u00E9\u010Den\u00FDch v letech 1997-2000 na Hemato-onkologick\u00E9 klinice FN a LF UP v Olomouci)" . . "Papaj\u00EDk, Tom\u00E1\u0161" . . "Indr\u00E1k, Karel" . "47" . "Prognostick\u00FD v\u00FDznam cytogenetick\u00FDch zm\u011Bn u nemocn\u00FDch s akutn\u00ED myeloidn\u00ED leuk\u00E9mi\u00ED (AML). (Anal\u00FDza v\u00FDsledk\u016F 105 nemocn\u00FDch l\u00E9\u010Den\u00FDch v letech 1997-2000 na Hemato-onkologick\u00E9 klinice FN a LF UP v Olomouci)"@cs . . "Chromosomov\u00E9 aberace jsou jedn\u00EDm z nejd\u016Fle\u017Eit\u011Bj\u0161\u00EDch prognostick\u00FDch faktor\u016F u nemocn\u00FDch s akutn\u00ED myeloidn\u00ED leuk\u00E9mi\u00ED (AML). V pr\u00E1ci p\u0159edkl\u00E1d\u00E1me anal\u00FDzu v\u00FDsledk\u016F klasick\u00E9 cytogenetiky roz\u0161\u00ED\u0159en\u00FDch o vy\u0161et\u0159en\u00ED metodou fluorescen\u010Dn\u00ED in situ hybridizace (FISH) u 105 nemocn\u00FDch v dob\u011B diagnosy AML. Do sledovan\u00E9ho souboru byli zahrnuti v\u0161ichni nemocn\u00ED s diagn\u00F3zou AML l\u00E9\u010Den\u00ED na Hemato-onkologick\u00E9 klinice FN a LF UP v Olomouci v pr\u016Fb\u011Bhu let 1997- 2000 standardn\u00ED induka\u010Dn\u00ED chemoterapi\u00ED, u nich\u017E byly dostupn\u00E9 hodnotiteln\u00E9 cytogenetick\u00E9 v\u00FDsledky z doby diagn\u00F3zy. Soubor m\u011Bl v\u011Bkov\u00FD medi\u00E1n 51 let (hranice 19-76 let) s m\u00EDrnou p\u0159evahou \u017Een (1,2 : 1). Chromosomov\u00E9 zm\u011Bny byly nalezeny u 63 (60 %) nemocn\u00FDch. Nej\u010Dast\u011Bji byly posti\u017Eeny (v po\u0159ad\u00ED podle \u010Detnosti) chromosomy 8, 17, 7, 5, 11, 15, 16 a 21. Na z\u00E1klad\u011B nalezen\u00FDch specifick\u00FDch a klon\u00E1ln\u00EDch chromosomov\u00FDch zm\u011Bn byl soubor rozd\u011Blen do 3 prognostick\u00FDch podskupin, kter\u00E9 byly statisticky porovn\u00E1ny. Podskupinu 17 nemocn\u00FDch s dobrou progn\u00F3zou tvo\u0159ilo 9 nemocn\u00FDch s akutn\u00ED pro"@cs . . "Prognostic importance of chromosomal changes in patients with acute myeloid leukemia (AML). (The analysis of results obtained from 105 patients treated at the Department of Hematology-Oncology, University Hospital, Olomouc, in 1997-2000)"@en . "Hub\u00E1\u010Dek, Jarom\u00EDr" . . "Prognostick\u00FD v\u00FDznam cytogenetick\u00FDch zm\u011Bn u nemocn\u00FDch s akutn\u00ED myeloidn\u00ED leuk\u00E9mi\u00ED (AML). (Anal\u00FDza v\u00FDsledk\u016F 105 nemocn\u00FDch l\u00E9\u010Den\u00FDch v letech 1997-2000 na Hemato-onkologick\u00E9 klinice FN a LF UP v Olomouci)"@cs . . . "Faber, Edgar" . "693233" . . "Prognostic importance of chromosomal changes in patients with acute myeloid leukemia (AML). (The analysis of results obtained from 105 patients treated at the Department of Hematology-Oncology, University Hospital, Olomouc, in 1997-2000)"@en . "Szotkowski, T." . "Jaro\u0161ov\u00E1, Marie" .