"P(EE2.3.30.0055)" . . "Gastrointestinal stromal tumors, morphological and immunohistochemical study. Forceps versus endoscopic ultrasound-guided fine-needle aspiration biopsy"@en . . "Motyka, Old\u0159ich" . . . "RIV/61989100:27740/14:86093063!RIV15-MSM-27740___" . . "\u017Didl\u00EDk, Pavel" . "5"^^ . "Zoundjiekpon, Vincent" . . "13"^^ . "Gastrointestin\u00E1ln\u00ED strom\u00E1ln\u00ED tumory, morfologick\u00E1 a imunohistochemick\u00E1 vy\u0161et\u0159en\u00ED z pohledu bioptick\u00E9ho a vytologick\u00E9ho odb\u011Bru"@cs . "D\u00EDt\u011B, Petr" . "[273A29BA4665]" . "\u0160imov\u00E1, Jarmila" . "27740" . "1"^^ . "Gastrointestin\u00E1ln\u00ED strom\u00E1ln\u00ED tumory, morfologick\u00E1 a imunohistochemick\u00E1 vy\u0161et\u0159en\u00ED z pohledu bioptick\u00E9ho a vytologick\u00E9ho odb\u011Bru"@cs . "prognostic; Ki-67; mitotic index; biopsy forceps; fine needle aspiration cytology-EUS FNA; gastrointestinal stromal tumor"@en . "Onkologie" . "http://www.onkologiecs.cz/pdfs/xon/2014/06/05.pdf" . . "Gastrointestin\u00E1ln\u00ED strom\u00E1ln\u00ED tumory, morfologick\u00E1 a imunohistochemick\u00E1 vy\u0161et\u0159en\u00ED z pohledu bioptick\u00E9ho a vytologick\u00E9ho odb\u011Bru" . "6" . . "Tomanov\u00E1, Radoslava" . . . "Gastrointestinal stromal tumors (GIST) belong to the most common mesenchymal tumors of digestive tract deriving from Cajal interstitial cells. A panel of immunohistochemical antibodies CD117, desmin, S100 and DOG1 is used to confirm the morphological diagnosis. When evaluating the biological characteristics we used a Miettinen classification for GIST which divides tumors into three groups according to a risk of aggressive behaviour. This classification observes three parameters-tumor localisation, its size and mitotic index. Mitotic index is defined as a number of mitoses in the tumor tissue on the overall area of 5 mm2. We performed a comparison of sampling methods-biopsy forceps, resection versus endoscopic ultrasound-guided fine-needle aspiration cytology (EUS FNA) from the point of view of a pathologist, focusing on the assessment of all necessary morphological and prognostic parameters of neoplasia. The study conclusions and experience show that when diagnosing GISTs, results of cytological examination of a sample using EUS FNA are comparable to those using forceps endoscopic biopsy. The main limitation of EUS FNA method is that in 75 % of cases it is impossible to state the mitotic index due to insufficient amount of tumor tissue. This tissue deficit may be replaced with an examination of a nuclear protein associated with cell proliferation Ki 67 which appears to be an independent prognostic parameter of disease progression."@en . . "Kliment, Martin" . "8" . "Urban, Ond\u0159ej" . . "Gastrointestin\u00E1ln\u00ED strom\u00E1ln\u00ED tumory (GIST) jako nej\u010Dast\u011Bj\u0161\u00ED mezenchym\u00E1ln\u00ED tumory tr\u00E1vic\u00EDho traktu vych\u00E1zej\u00ED z Cajalov\u00FDch interstici\u00E1ln\u00EDch bun\u011Bk. Ke konfirmaci morfologick\u00E9 diagn\u00F3zy jsme pou\u017Eili panel imunohistochemick\u00FDch protil\u00E1tek CD117, desmin, S100 a DOG1. P\u0159i hodnocen\u00ED biologick\u00FDch vlastnost\u00ED jsme vych\u00E1zeli z Miettinenovy klasifikace pro GIST, rozd\u011Bluj\u00EDc\u00ED tumory do t\u0159\u00ED skupin podle rizika agresivn\u00EDho chov\u00E1n\u00ED. Klasifikace tumoru sleduje t\u0159i parametry: lokalizaci, velikost a mitotick\u00FD index. Mitotick\u00FD index je definov\u00E1n jako po\u010Det mit\u00F3z v n\u00E1dorov\u00E9 tk\u00E1ni na celkov\u00E9 plo\u0161e 5 mm2. Provedli jsme srovn\u00E1n\u00ED metod odb\u011Bru tenkojehlov\u00E9, navigovan\u00E9 aspira\u010Dn\u00ED cytologie-EUS FNA a kle\u0161\u0165ov\u00E9 endoskopick\u00E9 biopsie \u010Di resek\u00E1tu n\u00E1dorov\u00E9 tk\u00E1n\u011B z pohledu patologa se zam\u011B\u0159en\u00EDm na stanoven\u00ED v\u0161ech pot\u0159ebn\u00FDch morfologick\u00FDch a prognostick\u00FDch parametr\u016F t\u00E9to neopl\u00E1zie. Na\u0161e z\u00E1v\u011Bry a zku\u0161enosti ukazuj\u00ED, \u017Ee v\u00FDsledky cytologick\u00E9ho vy\u0161et\u0159en\u00ED jsou pro diagnostiku GIST srovnateln\u00E9 s bioptick\u00FDm vy\u0161et\u0159en\u00EDm. Hlavn\u00ED limitac\u00ED cytologick\u00E9 metody je nemo\u017Enost v 75 % p\u0159\u00EDpad\u016F stanovit mitotick\u00FD index z d\u016Fvod\u016F mal\u00E9ho mno\u017Estv\u00ED n\u00E1dorov\u00E9 tk\u00E1n\u011B. Tento nedostatek lze nahradit vy\u0161et\u0159en\u00EDm nukle\u00E1rn\u00EDho proteinu asociovan\u00E9ho s bun\u011B\u010Dnou proliferac\u00ED Ki-67, kter\u00FD se dle liter\u00E1rn\u00EDch zdroj\u016F ukazuje jako v\u00FDznamn\u00FD prognostick\u00FD parametr progrese onemocn\u011Bn\u00ED."@cs . "Gastrointestin\u00E1ln\u00ED strom\u00E1ln\u00ED tumory (GIST) jako nej\u010Dast\u011Bj\u0161\u00ED mezenchym\u00E1ln\u00ED tumory tr\u00E1vic\u00EDho traktu vych\u00E1zej\u00ED z Cajalov\u00FDch interstici\u00E1ln\u00EDch bun\u011Bk. Ke konfirmaci morfologick\u00E9 diagn\u00F3zy jsme pou\u017Eili panel imunohistochemick\u00FDch protil\u00E1tek CD117, desmin, S100 a DOG1. P\u0159i hodnocen\u00ED biologick\u00FDch vlastnost\u00ED jsme vych\u00E1zeli z Miettinenovy klasifikace pro GIST, rozd\u011Bluj\u00EDc\u00ED tumory do t\u0159\u00ED skupin podle rizika agresivn\u00EDho chov\u00E1n\u00ED. Klasifikace tumoru sleduje t\u0159i parametry: lokalizaci, velikost a mitotick\u00FD index. Mitotick\u00FD index je definov\u00E1n jako po\u010Det mit\u00F3z v n\u00E1dorov\u00E9 tk\u00E1ni na celkov\u00E9 plo\u0161e 5 mm2. Provedli jsme srovn\u00E1n\u00ED metod odb\u011Bru tenkojehlov\u00E9, navigovan\u00E9 aspira\u010Dn\u00ED cytologie-EUS FNA a kle\u0161\u0165ov\u00E9 endoskopick\u00E9 biopsie \u010Di resek\u00E1tu n\u00E1dorov\u00E9 tk\u00E1n\u011B z pohledu patologa se zam\u011B\u0159en\u00EDm na stanoven\u00ED v\u0161ech pot\u0159ebn\u00FDch morfologick\u00FDch a prognostick\u00FDch parametr\u016F t\u00E9to neopl\u00E1zie. Na\u0161e z\u00E1v\u011Bry a zku\u0161enosti ukazuj\u00ED, \u017Ee v\u00FDsledky cytologick\u00E9ho vy\u0161et\u0159en\u00ED jsou pro diagnostiku GIST srovnateln\u00E9 s bioptick\u00FDm vy\u0161et\u0159en\u00EDm. Hlavn\u00ED limitac\u00ED cytologick\u00E9 metody je nemo\u017Enost v 75 % p\u0159\u00EDpad\u016F stanovit mitotick\u00FD index z d\u016Fvod\u016F mal\u00E9ho mno\u017Estv\u00ED n\u00E1dorov\u00E9 tk\u00E1n\u011B. Tento nedostatek lze nahradit vy\u0161et\u0159en\u00EDm nukle\u00E1rn\u00EDho proteinu asociovan\u00E9ho s bun\u011B\u010Dnou proliferac\u00ED Ki-67, kter\u00FD se dle liter\u00E1rn\u00EDch zdroj\u016F ukazuje jako v\u00FDznamn\u00FD prognostick\u00FD parametr progrese onemocn\u011Bn\u00ED." . "Gastrointestinal stromal tumors, morphological and immunohistochemical study. Forceps versus endoscopic ultrasound-guided fine-needle aspiration biopsy"@en . "Hurn\u00EDk, Pavel" . "\u017Diak, Du\u0161an" . "\u0160ust\u00EDkov\u00E1, Jarmila" . . "Uv\u00EDrov\u00E1, Magdalena" . . . "CZ - \u010Cesk\u00E1 republika" . "Dvo\u0159\u00E1\u010Dkov\u00E1, Jana" . . . "Gastrointestin\u00E1ln\u00ED strom\u00E1ln\u00ED tumory, morfologick\u00E1 a imunohistochemick\u00E1 vy\u0161et\u0159en\u00ED z pohledu bioptick\u00E9ho a vytologick\u00E9ho odb\u011Bru" . "RIV/61989100:27740/14:86093063" . "1802-4475" . . "17955" .