"978-80-87294-35-2" . . "Tokarsk\u00FD, Jon\u00E1\u0161" . "P(ED1.1.00/02.0070), S" . "2012-10-23+02:00"^^ . "141514" . "Influence of paraffin oil on behavior of gel-based drug carrier: molecular modeling study"@en . . "000333697100103" . . "Ostrava" . . . "RIV/61989100:27640/12:86084643!RIV14-MSM-27640___" . . "\u010Capkov\u00E1, Pavla" . "RIV/61989100:27640/12:86084643" . . . "Influence of paraffin oil on behavior of gel-based drug carrier: molecular modeling study" . . . "Influence of paraffin oil on behavior of gel-based drug carrier: molecular modeling study"@en . "Tanger s.r.o." . "[7C95085348BB]" . "Molecular modeling is nowadays routinely employed in many branches of science and pharmaceutical chemistry is not an exception. This modeling study was focused on behavior of amphiphilic gels mixture serving as a carriers of drug cyclosporine A (CsA) and the main aim was to find whether the contact with small amount of paraffin oil during the production can affect this behavior. Two systems were studied in Accelrys Materials Studio modeling environment: (1) pure gel-based CsA carrier and (2) gel-based drug carrier with small amount of paraffin oil added (~ 4 wt.%). The attention has been paid mainly to the homogeneity of CsA/gel clusters, pervasion of water into clusters and energy characteristics of clusters. It was found that the presence of small amount of paraffin oil does not affect the behavior of carrier."@en . . "Influence of paraffin oil on behavior of gel-based drug carrier: molecular modeling study" . . . "27640" . "2"^^ . "Brno" . . . . "2"^^ . "5"^^ . . "NANOCON 2012 : 4th international conference : conference proceedings : October 23rd-25th 2012, hotel Voron\u011B\u017E I, Brno, Czech Republic, EU" . . "molecular modeling; drug carrier; gel-based emulsion; cyclosporine A"@en . . "Molecular modeling is nowadays routinely employed in many branches of science and pharmaceutical chemistry is not an exception. This modeling study was focused on behavior of amphiphilic gels mixture serving as a carriers of drug cyclosporine A (CsA) and the main aim was to find whether the contact with small amount of paraffin oil during the production can affect this behavior. Two systems were studied in Accelrys Materials Studio modeling environment: (1) pure gel-based CsA carrier and (2) gel-based drug carrier with small amount of paraffin oil added (~ 4 wt.%). The attention has been paid mainly to the homogeneity of CsA/gel clusters, pervasion of water into clusters and energy characteristics of clusters. It was found that the presence of small amount of paraffin oil does not affect the behavior of carrier." . .