"GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "A large number of nuclear genes in the human parasite Blastocystis require mRNA polyadenylation to create functional termination codons"@en . "Termination codons in mRNA molecules are typically specified directly by the sequence of the corresponding gene. However, in mitochondria of a few eukaryotic groups, some mRNAs contain the termination codon UAA deriving one or both adenosines from transcript polyadenylation. Here, we show that a similar phenomenon occurs for a substantial number of nuclear genes in Blastocystis spp., divergent unicellular eukaryote gut parasites. Our analyses of published genomic data from Blastocystis sp. subtype 7 revealed that polyadenylation-mediated creation of termination codons occurs in approximately 15% of all nuclear genes. As this phenomenon has not been noticed before, the procedure previously employed to annotate the Blastocystis nuclear genome sequence failed to correctly define the structure of the 30-ends of hundreds of genes. From sequence data we have obtained from the distantly related Blastocystis sp. subtype 1 strain, we show that this phenomenon is widespread within the Blastocystis genus?" . "RIV/61988987:17310/14:A1501CHD" . "797" . . "Gentekaki, E." . . "Termination codons in mRNA molecules are typically specified directly by the sequence of the corresponding gene. However, in mitochondria of a few eukaryotic groups, some mRNAs contain the termination codon UAA deriving one or both adenosines from transcript polyadenylation. Here, we show that a similar phenomenon occurs for a substantial number of nuclear genes in Blastocystis spp., divergent unicellular eukaryote gut parasites. Our analyses of published genomic data from Blastocystis sp. subtype 7 revealed that polyadenylation-mediated creation of termination codons occurs in approximately 15% of all nuclear genes. As this phenomenon has not been noticed before, the procedure previously employed to annotate the Blastocystis nuclear genome sequence failed to correctly define the structure of the 30-ends of hundreds of genes. From sequence data we have obtained from the distantly related Blastocystis sp. subtype 1 strain, we show that this phenomenon is widespread within the Blastocystis genus?"@en . "Eli\u00E1\u0161, Marek" . . . . "1759-6653" . "17310" . . . "A large number of nuclear genes in the human parasite Blastocystis require mRNA polyadenylation to create functional termination codons" . . . . "[365EED5197BE]" . . "8" . . . "Roger, A. J." . "Genome Biology and Evolution" . . "A large number of nuclear genes in the human parasite Blastocystis require mRNA polyadenylation to create functional termination codons"@en . "6" . "Blastocystis; evolution; gene expression; mRNA processing; polyadenylation; termination codons; translation"@en . . "Klime\u0161, Vladim\u00EDr" . "6"^^ . "RIV/61988987:17310/14:A1501CHD!RIV15-MSM-17310___" . . . "P(ED2.1.00/03.0100), P(GA13-33039S), P(LO1208)" . "2"^^ . "4"^^ . . "000342976600004" . . "A large number of nuclear genes in the human parasite Blastocystis require mRNA polyadenylation to create functional termination codons" . . .