. "2"^^ . "Antigenotoxic effects of a bark extract from Magnolia officinalis" . . "\u010Casopis slezsk\u00E9ho zemsk\u00E9ho muzea (A)" . "RIV/61988987:17310/12:A13017G5" . "Rybkov\u00E1, Zuzana" . "The aim was to detect antimutagenic and DNA protective effects of a plant extract from bark of Magnolia officinalis adversing oxidative DNA damage. The ability to inhibit mutagenicity induced by tert-butyl hydroperoxide (t-BOOH) and hydrogen peroxide (H2O2) was determined with Ames test using Salmonella typhimurium His- TA102 bacterial strain. Inhibition values of 72.8 and 98.7 % were detected for t-BOOH and H2O2, respectively. The protective effect of the extract against DNA strand scission induced by hydroxyl radicals was studied with plasmid pBluescript II SK(-). The analysis of DNA strand breaks in the plasmid DNA proved a significant inhibition of DNA damage."@en . "[418926B1DD52]" . . "CZ - \u010Cesk\u00E1 republika" . . "P(ED2.1.00/03.0100)" . "2"^^ . "17310" . "Malachov\u00E1, Kate\u0159ina" . "Ames test; Antimutagenicity; DNA strand scission; Magnolia officinalis"@en . "3" . . . . . "1" . "RIV/61988987:17310/12:A13017G5!RIV13-MSM-17310___" . "Antigenotoxic effects of a bark extract from Magnolia officinalis"@en . "Antigenotoxic effects of a bark extract from Magnolia officinalis" . . . "122948" . . "Antigenotoxic effects of a bark extract from Magnolia officinalis"@en . . . . "1211-3026" . . . . "6"^^ . "The aim was to detect antimutagenic and DNA protective effects of a plant extract from bark of Magnolia officinalis adversing oxidative DNA damage. The ability to inhibit mutagenicity induced by tert-butyl hydroperoxide (t-BOOH) and hydrogen peroxide (H2O2) was determined with Ames test using Salmonella typhimurium His- TA102 bacterial strain. Inhibition values of 72.8 and 98.7 % were detected for t-BOOH and H2O2, respectively. The protective effect of the extract against DNA strand scission induced by hydroxyl radicals was studied with plasmid pBluescript II SK(-). The analysis of DNA strand breaks in the plasmid DNA proved a significant inhibition of DNA damage." . .