. "CZ - \u010Cesk\u00E1 republika" . . "Crohnova nemoc se \u010Dasto projevuje \u010Dist\u011B jako z\u00E1n\u011Btliv\u00E9 onemocn\u011Bn\u00ED, ale u mnoha pacient\u016F se vyvine v komplikovan\u00E9 onemocn\u011Bn\u00ED charakterizovan\u00E9 tvorbou striktur nebo p\u00ED\u0161t\u011Bl\u00ED. P\u0159esn\u00E1 etiopatogeneze tohoto z\u00E1va\u017En\u00E9ho onemocn\u011Bn\u00ED nen\u00ED zcela jednozna\u010Dn\u011B objasn\u011Bna, a to i p\u0159es ve\u0161ker\u00E9 \u00FAsil\u00ED v\u00FDzkumu a p\u0159es pozn\u00E1n\u00ED \u0159ady d\u00EDl\u010D\u00EDch patogenetick\u00FDch mechanizm\u016F. Mnoho studi\u00ED nazna\u010Duje, \u017Ee se zv\u00FD\u0161en\u00FDm rizikem rozvoje komplikovan\u00E9 formy onemocn\u011Bn\u00ED souvis\u00ED zejm\u00E9na varianty v NOD2/CARD15 genu." . "RIV/61988987:17110/14:A1501DW8!RIV15-MSM-17110___" . . . . "9227" . . "Crohnova nemoc - genetick\u00E9 faktory z pohledu etiopatogeneze" . . "Crohnova nemoc se \u010Dasto projevuje \u010Dist\u011B jako z\u00E1n\u011Btliv\u00E9 onemocn\u011Bn\u00ED, ale u mnoha pacient\u016F se vyvine v komplikovan\u00E9 onemocn\u011Bn\u00ED charakterizovan\u00E9 tvorbou striktur nebo p\u00ED\u0161t\u011Bl\u00ED. P\u0159esn\u00E1 etiopatogeneze tohoto z\u00E1va\u017En\u00E9ho onemocn\u011Bn\u00ED nen\u00ED zcela jednozna\u010Dn\u011B objasn\u011Bna, a to i p\u0159es ve\u0161ker\u00E9 \u00FAsil\u00ED v\u00FDzkumu a p\u0159es pozn\u00E1n\u00ED \u0159ady d\u00EDl\u010D\u00EDch patogenetick\u00FDch mechanizm\u016F. Mnoho studi\u00ED nazna\u010Duje, \u017Ee se zv\u00FD\u0161en\u00FDm rizikem rozvoje komplikovan\u00E9 formy onemocn\u011Bn\u00ED souvis\u00ED zejm\u00E9na varianty v NOD2/CARD15 genu."@cs . "17110" . "60" . "Crohn's disease - etiopathogenetic factors"@en . "Vnit\u0159n\u00ED l\u00E9ka\u0159stv\u00ED" . . "Svoboda, Pavel" . "biologic treatment; Crohn?s disease; fenotypization; genetic; imunobiology"@en . "\u0160imov\u00E1, Jarmila" . "[2BEA1268BF91]" . "Kupka, Tom\u00E1\u0161" . "Mart\u00EDnek, Lubom\u00EDr" . "I" . "9"^^ . "RIV/61988987:17110/14:A1501DW8" . "Bojkov\u00E1, Martina" . . . . . "Klva\u0148a, Pavel" . "8"^^ . "Crohnova nemoc - genetick\u00E9 faktory z pohledu etiopatogeneze"@cs . "5"^^ . "Crohn's disease is often purely inflammatory, but most patients develop complicated disease with strictures or fistulae. Specific etiopathogenesis of this severe disease is not definitely clear despite research efforts and learning of many pathogenetic mechanisms. Many studies have suggested that NOD2 mutations are associated with in\u00ADcreased risk of complicated disease. Presence of NOD2 mutation itself is just one of factors contributing to development of this disease."@en . "Crohnova nemoc - genetick\u00E9 faktory z pohledu etiopatogeneze" . . . . "Uv\u00EDrov\u00E1, Magdalena" . . . "Dovrt\u011Blov\u00E1, Lenka" . "Crohnova nemoc - genetick\u00E9 faktory z pohledu etiopatogeneze"@cs . . . . "7-8" . "0042-773X" . "Crohn's disease - etiopathogenetic factors"@en . . "D\u00EDt\u011B, Petr" . . .