"30321" . "Kubov\u00E1, B." . "2"^^ . . "Molekul\u00E1rn\u00ED genetika u gastrointestin\u00E1ln\u00EDch strom\u00E1ln\u00EDch tumor\u016F" . "Onkologie" . "Mart\u00EDnek, Arno\u0161t" . . . "Molecular genetics in gastrointestinal stromal tumors"@en . "CZ - \u010Cesk\u00E1 republika" . "Molecular genetics in gastrointestinal stromal tumors"@en . . "RIV/61988987:17110/14:A1501DH3" . "Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the gastrointestinal tract (GI) arising from the interstitial cells of Cajal, primarily of the stomach and small intestine. During the past decade came up to progress of molecular targeted therapies for many solid tumors and in association with discovery of onkogenic kinase mutations in GISTs to rapid evolution in understanding of molecular biology features of these tumors and to implementation tyrosine kinase inhibitors in clinical practice."@en . . "6" . "gastrointestinal stromal tumor; mutation; KIT gene; PDGFRA gene"@en . . . . . . . . "8" . "Dvo\u0159\u00E1\u010Dkov\u00E1, Jana" . . . "I" . "Molekul\u00E1rn\u00ED genetika u gastrointestin\u00E1ln\u00EDch strom\u00E1ln\u00EDch tumor\u016F"@cs . "Molekul\u00E1rn\u00ED genetika u gastrointestin\u00E1ln\u00EDch strom\u00E1ln\u00EDch tumor\u016F" . "Uv\u00EDrov\u00E1, Magdalena" . "\u0160imov\u00E1, Jarmila" . "Gastrointestin\u00E1ln\u00ED strom\u00E1ln\u00ED n\u00E1dory (GISTy) jsou mezenchym\u00E1ln\u00ED n\u00E1dory gastrointestin\u00E1ln\u00EDho traktu (GI), poch\u00E1zej\u00EDc\u00ED z intestin\u00E1ln\u00EDch Cajalov\u00FDch bun\u011Bk p\u0159ev\u00E1\u017En\u011B ze \u017Ealudku a tenk\u00E9ho st\u0159eva. V posledn\u00EDm desetilet\u00ED do\u0161lo k rozvoji c\u00EDlen\u00E9 molekul\u00E1rn\u00ED l\u00E9\u010Dby mnoha solidn\u00EDch n\u00E1dor\u016F a s objevem onkogenn\u00EDch mutac\u00ED kin\u00E1z u GIST\u016F do\u0161lo k rychl\u00E9mu pochopen\u00ED molekul\u00E1rn\u011B biologick\u00E9 povahy t\u011Bchto n\u00E1dor\u016F a p\u0159isp\u011Blo k zaveden\u00ED inhibitor\u016F tyrozinkin\u00E1z do klinick\u00E9 praxe i u tohoto typu n\u00E1dor\u016F." . . . "Molekul\u00E1rn\u00ED genetika u gastrointestin\u00E1ln\u00EDch strom\u00E1ln\u00EDch tumor\u016F"@cs . "9"^^ . "\u017Dmol\u00EDkov\u00E1, Jana" . "1802-4475" . "D\u00EDt\u011B, Petr" . . . "17110" . "Urbanovsk\u00E1, Irena" . "7"^^ . "Gastrointestin\u00E1ln\u00ED strom\u00E1ln\u00ED n\u00E1dory (GISTy) jsou mezenchym\u00E1ln\u00ED n\u00E1dory gastrointestin\u00E1ln\u00EDho traktu (GI), poch\u00E1zej\u00EDc\u00ED z intestin\u00E1ln\u00EDch Cajalov\u00FDch bun\u011Bk p\u0159ev\u00E1\u017En\u011B ze \u017Ealudku a tenk\u00E9ho st\u0159eva. V posledn\u00EDm desetilet\u00ED do\u0161lo k rozvoji c\u00EDlen\u00E9 molekul\u00E1rn\u00ED l\u00E9\u010Dby mnoha solidn\u00EDch n\u00E1dor\u016F a s objevem onkogenn\u00EDch mutac\u00ED kin\u00E1z u GIST\u016F do\u0161lo k rychl\u00E9mu pochopen\u00ED molekul\u00E1rn\u011B biologick\u00E9 povahy t\u011Bchto n\u00E1dor\u016F a p\u0159isp\u011Blo k zaveden\u00ED inhibitor\u016F tyrozinkin\u00E1z do klinick\u00E9 praxe i u tohoto typu n\u00E1dor\u016F."@cs . . "RIV/61988987:17110/14:A1501DH3!RIV15-MSM-17110___" . . . "\u017Diak, D." . "[DC9422B44370]" .