. "2" . . . "Our present knowledge on aetiological factors is documented by a disease classification called TIGARO. Besides ?classical? toxonutritive factors, important factors are genetic and autoimmune influence and condition indicating pancreatic duct obstruction. It is known that no more than 10 % of alcoholics will suffer from chronic pancreatitis, out of which is logical a necessity of coexistence of other risk factors for induction of fibrotic gland changes, e.g. combination of alcohol abuse and smoking."@en . "RIV/61988987:17110/13:A14019S8" . "GASTROENTEROL\u00D3GIA PRE PRAX" . "PRESENT OVERVIEW OF AETIOLOGY AND PATHOGENESIS OF CHRONIC PANCREATITIS"@en . "D\u00EDt\u011B, Petr" . . . . "3"^^ . "Sou\u010Dasn\u00E9 pohledy na etiopatogenezu chronick\u00E9 pankreatitidy"@cs . . . "Novotn\u00FD, I." . "Bojkov\u00E1, M." . . . . "RIV/61988987:17110/13:A14019S8!RIV14-MSM-17110___" . "Kiani\u010Dka, B." . "Nechutov\u00E1, H." . "106525" . "Klva\u0148a, Pavel" . "chronic pancreatitis; TIGARO classification; alcohol; genetics; outlet obstruction"@en . "Mart\u00EDnek, Arno\u0161t" . "Sou\u010Dasn\u00E9 pohledy na etiopatogenezu chronick\u00E9 pankreatitidy"@cs . "1336-1473" . . "[C7A590A77428]" . . "Sou\u010Dasn\u00E9 pohledy na etiopatogenezu chronick\u00E9 pankreatitidy" . "I" . . "SK - Slovensk\u00E1 republika" . "Sou\u010Dasn\u00E9 pohledy na etiopatogenezu chronick\u00E9 pankreatitidy" . "Na\u0161e sou\u010Dasn\u00E9 poznatky o etiologick\u00FDch faktorech dokumentuje klasifikace nemoci, ozna\u010Den\u00E1 jako TIGARO. Krom\u011B ?klasick\u00FDch? faktor\u016F toxonutritivn\u00EDch jsou v\u00FDznamn\u00FDm faktorem vlivy genetick\u00E9, autoimunitn\u00ED a stavy indukuj\u00EDc\u00ED obstrukci pankreatick\u00E9ho v\u00FDvodu. Je zn\u00E1mo, \u017Ee ne v\u00EDce ne\u017E 10 % alkoholik\u016F onemocn\u00ED chronickou pankreatitidou, z \u010Deho\u017E logick\u00E1 pot\u0159eba koexistence dal\u0161\u00EDch rizikov\u00FDch faktor\u016F pro indukci fibrotick\u00FDch zm\u011Bn \u017El\u00E1zy, nap\u0159. kombinace abusu alkoholu a kou\u0159en\u00ED. Samostatn\u00FDm faktorem indukuj\u00EDcim chronickou pankreatitidu je p\u0159\u00EDtomnost genu PRSS pro kationick\u00FD trypsinogen, zn\u00E1m\u00E9ho jako kauz\u00E1ln\u00ED gen heredit\u00E1rn\u00ED pankreatitidy. Ostatn\u00ED geny, spojen\u00E9 se vznikem chronick\u00E9 pankreatitidy, t. j. CFTR mutace a SPINK1 gen samostatn\u011B nevyvolaj\u00ED onemocn\u011Bn\u00ED, ale nap\u0159. s alkoholem jsou faktory v\u00FDznamn\u00FDmi."@cs . . . . "3"^^ . "PRESENT OVERVIEW OF AETIOLOGY AND PATHOGENESIS OF CHRONIC PANCREATITIS"@en . "Bodai, A." . . "Na\u0161e sou\u010Dasn\u00E9 poznatky o etiologick\u00FDch faktorech dokumentuje klasifikace nemoci, ozna\u010Den\u00E1 jako TIGARO. Krom\u011B ?klasick\u00FDch? faktor\u016F toxonutritivn\u00EDch jsou v\u00FDznamn\u00FDm faktorem vlivy genetick\u00E9, autoimunitn\u00ED a stavy indukuj\u00EDc\u00ED obstrukci pankreatick\u00E9ho v\u00FDvodu. Je zn\u00E1mo, \u017Ee ne v\u00EDce ne\u017E 10 % alkoholik\u016F onemocn\u00ED chronickou pankreatitidou, z \u010Deho\u017E logick\u00E1 pot\u0159eba koexistence dal\u0161\u00EDch rizikov\u00FDch faktor\u016F pro indukci fibrotick\u00FDch zm\u011Bn \u017El\u00E1zy, nap\u0159. kombinace abusu alkoholu a kou\u0159en\u00ED. Samostatn\u00FDm faktorem indukuj\u00EDcim chronickou pankreatitidu je p\u0159\u00EDtomnost genu PRSS pro kationick\u00FD trypsinogen, zn\u00E1m\u00E9ho jako kauz\u00E1ln\u00ED gen heredit\u00E1rn\u00ED pankreatitidy. Ostatn\u00ED geny, spojen\u00E9 se vznikem chronick\u00E9 pankreatitidy, t. j. CFTR mutace a SPINK1 gen samostatn\u011B nevyvolaj\u00ED onemocn\u011Bn\u00ED, ale nap\u0159. s alkoholem jsou faktory v\u00FDznamn\u00FDmi." . "Sou\u010Dek, A." . "17110" . "9"^^ . .