"1802-4475" . "7" . "CZ - \u010Cesk\u00E1 republika" . . "Melanocyt\u00E1rn\u00ED l\u00E9ze vykazuj\u00ED zna\u010Dnou morfologickou heterogenitu. Jejich diagnostika je n\u00E1ro\u010Dn\u00E1 i p\u0159es sou\u010Dasn\u00E9 vyu\u017Eit\u00ED modern\u00EDch histopatologick\u00FDch a imunohistochemick\u00FDch metod. V\u00FDznamn\u00FDm p\u0159\u00EDnosem v diagnostice melanocyt\u00E1rn\u00EDch l\u00E9z\u00ED je zaveden\u00ED molekul\u00E1rn\u011B genetick\u00E9 metody fluorescen\u010Dn\u00ED in situ hybridizace s pou\u017Eit\u00EDm \u010Dty\u0159barevn\u00E9 sondy zna\u010D\u00EDc\u00ED geny CCND1, RREB1, MYB a centromeru chromozomu 6. V letech 2008-2012 bylo v na\u0161\u00ED laborato\u0159i \u00FAsp\u011B\u0161n\u011B metodou fluorescen\u010Dn\u00ED in situ hybridizace vy\u0161et\u0159eno 160 vzork\u016F r\u016Fzn\u00FDch typ\u016F melanocyt\u00E1rn\u00EDch l\u00E9z\u00ED, 44 n\u00E9v\u016F a 116 melanom\u016F." . . "Vyu\u017Eit\u00ED fluorescen\u010Dn\u00ED in situ hybridizace v diagnostice melanocyt\u00E1rn\u00EDch l\u00E9z\u00ED" . "Mu\u017E\u00EDk, Jan" . . "3"^^ . "Vyu\u017Eit\u00ED fluorescen\u010Dn\u00ED in situ hybridizace v diagnostice melanocyt\u00E1rn\u00EDch l\u00E9z\u00ED"@cs . "115986" . . . "4"^^ . . "Melanocyt\u00E1rn\u00ED l\u00E9ze vykazuj\u00ED zna\u010Dnou morfologickou heterogenitu. Jejich diagnostika je n\u00E1ro\u010Dn\u00E1 i p\u0159es sou\u010Dasn\u00E9 vyu\u017Eit\u00ED modern\u00EDch histopatologick\u00FDch a imunohistochemick\u00FDch metod. V\u00FDznamn\u00FDm p\u0159\u00EDnosem v diagnostice melanocyt\u00E1rn\u00EDch l\u00E9z\u00ED je zaveden\u00ED molekul\u00E1rn\u011B genetick\u00E9 metody fluorescen\u010Dn\u00ED in situ hybridizace s pou\u017Eit\u00EDm \u010Dty\u0159barevn\u00E9 sondy zna\u010D\u00EDc\u00ED geny CCND1, RREB1, MYB a centromeru chromozomu 6. V letech 2008-2012 bylo v na\u0161\u00ED laborato\u0159i \u00FAsp\u011B\u0161n\u011B metodou fluorescen\u010Dn\u00ED in situ hybridizace vy\u0161et\u0159eno 160 vzork\u016F r\u016Fzn\u00FDch typ\u016F melanocyt\u00E1rn\u00EDch l\u00E9z\u00ED, 44 n\u00E9v\u016F a 116 melanom\u016F."@cs . . "[255D81D0927D]" . "Onkologie" . . "4"^^ . . . "I, V" . . . "Fluorescence in situ hybridization in diagnostics melanocytic lesions"@en . . "Vyu\u017Eit\u00ED fluorescen\u010Dn\u00ED in situ hybridizace v diagnostice melanocyt\u00E1rn\u00EDch l\u00E9z\u00ED" . "Fluorescence in situ hybridization in diagnostics melanocytic lesions"@en . . . . "Dvo\u0159\u00E1\u010Dkov\u00E1, Jana" . "Melanocytic lesions exhibit significant morphological heterogenity, making their diagnosis difficult, although both sophisticated histopathological and immunohistochemical methods are used. The introduction of molecular genetic method flourescence in situ hybridization (FISH) has contributed significantly to the diagnosing of melanocytic lesions. Between 2008 and 2012, we studied a total of 160 samples of different types of melanocytic lesions, including 44 nevi and 116 melanomas, using a four-color probe mix for CCND1, RREB1 and MYB genes and for the centromere of chromosome 6."@en . "17110" . "Vyu\u017Eit\u00ED fluorescen\u010Dn\u00ED in situ hybridizace v diagnostice melanocyt\u00E1rn\u00EDch l\u00E9z\u00ED"@cs . "\u017Dmol\u00EDkov\u00E1, Jana" . "melanoma; naevus; fluorescence in situ hybridization; FISH; gene"@en . "RIV/61988987:17110/13:A14018SQ" . . . . . "Uv\u00EDrov\u00E1, Magdalena" . "2" . "RIV/61988987:17110/13:A14018SQ!RIV14-MSM-17110___" .