. . . . "Beta-blok\u00E1tory pat\u0159\u00ED mezi z\u00E1kladn\u00ED l\u00E9\u010Diva v terapii kardiovaskul\u00E1rn\u00EDch onemocn\u011Bn\u00ED. Jejich spole\u010Dn\u00FD mechanizmus \u00FA\u010Dinku je zalo\u017Een\u00FD na blok\u00E1d\u011B \u00DF-adrenergn\u00EDch receptor\u016F. Av\u0161ak v r\u00E1mci skupiny beta-blok\u00E1tor\u016F existuj\u00ED mezi jednotliv\u00FDmi l\u00E1tkami farmakokinetick\u00E9 a farmakodynamick\u00E9 rozd\u00EDly, kter\u00E9 jsou klinicky relevantn\u00ED. Nav\u00EDc odpov\u011B\u010F na beta-blok\u00E1tor se m\u016F\u017Ee mezi pacienty li\u0161it. Na tom m\u00E1 ur\u010Dit\u00FD pod\u00EDl genetick\u00FD polymorfizmus biotranforma\u010Dn\u00EDch enzym\u016F cytochr\u00F3mu P450 (d\u00E1le jen P450), v\u010Detn\u011B P450 2D6, kter\u00FDm se biotransformuje n\u011Bkolik b\u011B\u017En\u011B u\u017E\u00EDvan\u00FDch beta-blok\u00E1tor\u016F. Rozpozn\u00E1n\u00ED vlastnost\u00ED a odli\u0161nost\u00ED mezi beta-blok\u00E1tory je nezbytn\u00E9 pro jejich klinick\u00E9 vyu\u017Eit\u00ED."@cs . "Beta-blok\u00E1tory"@cs . . "RIV/61988987:17110/09:A0900VF7!RIV09-MSM-17110___" . "Beta-blok\u00E1tory" . "2" . "Beta-blok\u00E1tory" . . "Beta-adrenergic blockers rank among the principal drugs in the treatment of cardiovascular diseases. Their common mechanism of action is based on the \u00DF-adrenergic receptor blockade. However, differences in pharmacokinetic and pharmacodynamic properties exist between the individual agents in the beta-blocker class, and these differences may be of clinical relevance. In addition, responses to beta-blockers are variable among patients. Genetic plymorphism in drug-metabolizing enzymes, including cytochrome P450 2D6, has been demonstrated to contribute to the variability of several beta-blockers. The understanding of beta-blocker properties and their differences is thus important for their proper clinical use."@en . . . "304914" . . "1"^^ . "Beta-blockers"@en . "Beta-blok\u00E1tory Beta-blok\u00E1tory patria medzi z\u00E1kladn\u00E9 lie\u010Div\u00E1 v terapii kardiovaskul\u00E1rnych ochoren\u00ED. Ich spolo\u010Dn\u00FD mechanizmus \u00FA\u010Dinku je zalo\u017Een\u00FD na blok\u00E1de \u00DF-adrenergn\u00FDch receptorov. Av\u0161ak v r\u00E1mci skupiny beta-blok\u00E1torov existuj\u00FA medzi jednotliv\u00FDmi l\u00E1tkami farmakokinetick\u00E9 a farmakodynamick\u00E9 rozdiely, ktor\u00E9 s\u00FA klinicky relevantn\u00E9. Naviac odpove\u010F na beta-blok\u00E1tor sa m\u00F4\u017Ee medzi pacientmi l\u00ED\u0161i\u0165. Na tom m\u00E1 ur\u010Dit\u00FD podiel genetick\u00FD polymorfizmus biotransforma\u010Dn\u00FDch enz\u00FDmov cytochr\u00F3mu P450 (\u010Falej len P450), vr\u00E1tane P450 2D6, ktor\u00FDm sa biotransformuje nieko\u013Eko be\u017Ene u\u017E\u00EDvan\u00FDch beta-blok\u00E1torov. Poznanie vlastnost\u00ED a teda odli\u0161nost\u00ED medzi beta-blok\u00E1tormi je nevyhnutn\u00E9 pre ich spr\u00E1vne klinick\u00E9 vyu\u017Eitie." . . "RIV/61988987:17110/09:A0900VF7" . "\u010Cesk\u00E1 a slovensk\u00E1 farmacie" . "Beta-blok\u00E1tory"@cs . "Beta-blockers"@en . . "2"^^ . . "58" . "Grundmann, Milan" . "CZ - \u010Cesk\u00E1 republika" . "S" . "17110" . "\u010Euricov\u00E1, Jana" . . "[2CA9FAA6A1FA]" . . "1210-7816" . . "7"^^ . "beta-blockers; pharmacokinetics; pharmacodynamics; P450 2D6"@en .