"CYP2D6; polymorphism; phenotype"@en . "S" . "3-4" . . . "The enzymes of the cytochrome P450 are the major enzymes responsible for metabolizing of drugs. The CYP2D6 is highly polymorphic enzyme and shows a very high degree of interindividual variability. The CYP2D6 metabolizes approximately 25% of all medications. Many studies point out the significant influence of CYP2D6 on pharmacokinetics and pharmacodynamics of drugs."@en . . . "CYP2D6 and its clinical significance"@en . . . "1212-7973" . . "CYP2D6 a jeho klinick\u00FD v\u00FDznam"@cs . "21" . "Klin Farmakol Farm" . "CYP2D6 and its clinical significance"@en . "1"^^ . . "2"^^ . . . "CYP2D6 a jeho klinick\u00FD v\u00FDznam" . "\u010Euricov\u00E1, Jana" . "CYP2D6 a jeho klinick\u00FD v\u00FDznam"@cs . "Enzymy cytochromu P450 jsou hlavn\u00EDmi enzymy pod\u00EDlej\u00EDc\u00ED se na metabolismu l\u00E9\u010Div. CYP2D6 je vysoko polymorfick\u00FD enzym, kter\u00FD vykazuje vysok\u00FD stupe\u0148 interindividu\u00E1ln\u00ED variability. CYP2D6 metabolizuje p\u0159ibli\u017En\u011B 25% v\u0161ech l\u00E9\u010Div. Mnoh\u00E9 studie poukazuj\u00ED na v\u00FDznamn\u00FD vliv CYP2D6 polymorfizmu na farmakokinetiku a farmakodynamiku l\u00E9\u010Div."@cs . . . "Enz\u00FDmy cytochr\u00F3mu P450 s\u00FA hlavn\u00FDmi enz\u00FDmami podie\u013Eaj\u00FAcimi sa na metabolizme lie\u010Div. CYP2D6 je vysoko polymorfick\u00FD enz\u00FDm, ktor\u00FD vykazuje vysok\u00FD stupe\u0148 interindividu\u00E1lnej variability. CYP2D6 metabolizuje pribli\u017Ene 25% v\u0161etk\u00FDch lie\u010Div. Mnoh\u00E9 \u0161t\u00FAdie poukazuj\u00FA na v\u00FDznamn\u00FD vplyv CYP2D6 polymorfizmu na farmakokinetiku a farmakodynamiku lie\u010Div." . "2"^^ . "415524" . "[DF05273AF0E8]" . "17110" . "RIV/61988987:17110/07:A0900MLM!RIV09-MSM-17110___" . "CYP2D6 a jeho klinick\u00FD v\u00FDznam" . "CZ - \u010Cesk\u00E1 republika" . . "Grundmann, Milan" . . "RIV/61988987:17110/07:A0900MLM" .