. "10.1016/j.ejmech.2013.08.009" . . "Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines" . . . "7"^^ . . "Kry\u0161tof, Vladim\u00EDr" . . "Variously substituted 2-hydroxy-N-(arylallcyl)benzamides were prepared and screened for anti-proliferative and cytotoxic activity in cancer cell lines in vitro. Five compounds, out of 33 showed single-digit micromolar IC50 values against several human cancer cell lines. One of the most potent compounds N-((R)-1-(4-chlorophenylcarbamoyl)-2-phenylethyl)-5-chloro-2-hydroxybenzamide (6k) reduced proliferation and induced apoptosis in the melanoma cell line G361 in a dose-dependent manner, as shown by decrease in 5-bromo-2'-deoxyuridine incorporation and increase in several apoptotic markers, including subdiploid population increase, activation of caspases and site-specific poly-(ADP-ribose)polymerase (PARP) cleavage." . "3"^^ . "P(ED2.1.00/03.0101), P(GA301/08/1649), P(GAP305/12/0783), S, Z(AV0Z50380511)" . . . "RIV/61389030:_____/13:00423094!RIV14-GA0-61389030" . . "0223-5234" . "FR - Francouzsk\u00E1 republika" . . "108907" . "RIV/61389030:_____/13:00423094" . . "Pauk, K." . . "Hanousek, J." . . "\u0158ezn\u00ED\u010Dkov\u00E1, Eva" . . "Diamides; Apoptosis; Cytotoxicity"@en . "000326902300027" . "68" . "Jorda, Radek" . . "European Journal of Medicinal Chemistry" . . . . "2013" . . . "Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines"@en . . "Imramovsk\u00FD, A." . "Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines"@en . "Du\u0161ek, J." . "7"^^ . "Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines" . . "[477C1D723230]" . . "Variously substituted 2-hydroxy-N-(arylallcyl)benzamides were prepared and screened for anti-proliferative and cytotoxic activity in cancer cell lines in vitro. Five compounds, out of 33 showed single-digit micromolar IC50 values against several human cancer cell lines. One of the most potent compounds N-((R)-1-(4-chlorophenylcarbamoyl)-2-phenylethyl)-5-chloro-2-hydroxybenzamide (6k) reduced proliferation and induced apoptosis in the melanoma cell line G361 in a dose-dependent manner, as shown by decrease in 5-bromo-2'-deoxyuridine incorporation and increase in several apoptotic markers, including subdiploid population increase, activation of caspases and site-specific poly-(ADP-ribose)polymerase (PARP) cleavage."@en .