. . "233917" . . . . . "[A4C101C34E46]" . "2" . . "THE SYNTHESIS OF SOME DERIVATIVES BASED ON THE 4-BENZYL-1H-PYRAZOLE-3,5-DIAMINE CORE"@en . "10.3987/COM-10-12101" . . "000287562900012" . . "88" . . "THE SYNTHESIS OF SOME DERIVATIVES BASED ON THE 4-BENZYL-1H-PYRAZOLE-3,5-DIAMINE CORE" . "THE SYNTHESIS OF SOME DERIVATIVES BASED ON THE 4-BENZYL-1H-PYRAZOLE-3,5-DIAMINE CORE" . . . "3"^^ . "Canka\u0159, Petr" . . "13"^^ . "RIV/61389030:_____/11:00368591!RIV12-AV0-61389030" . "Heterocycles" . "The three-step synthesis of 4-benzyl-1H-pyrazole-3,5-diamines 2 from commercially available aldehydes 3 is given. The Knoevenagel condensation was utilized to assemble the initial carbon framework, resulting in the benzylidenemalononitriles 4 which were directly transformed by the reduction of the electron deficient C=C bond to benzylmalononitriles 5. Subsequent cycloaddition of hydrazine with 5 afforded the desired pyrazoles 2. Due to the high similarity with 4-arylazo-1H-pyrazole-3,5-diamines, the biological activities of the 4-benzyl-1H-pyrazole-3,5-diamines 2 were evaluated while focusing on the inhibition of cyclin-dependent kinases (CDKs), but no significant results were obtained."@en . . "RIV/61389030:_____/11:00368591" . "Knoevenagel Condensation; Olefin Reduction; CDK; Hydrazine Cycloaddition; Pyrazole-3,5-diamine"@en . "2"^^ . "JP - Japonsko" . . . . "The three-step synthesis of 4-benzyl-1H-pyrazole-3,5-diamines 2 from commercially available aldehydes 3 is given. The Knoevenagel condensation was utilized to assemble the initial carbon framework, resulting in the benzylidenemalononitriles 4 which were directly transformed by the reduction of the electron deficient C=C bond to benzylmalononitriles 5. Subsequent cycloaddition of hydrazine with 5 afforded the desired pyrazoles 2. Due to the high similarity with 4-arylazo-1H-pyrazole-3,5-diamines, the biological activities of the 4-benzyl-1H-pyrazole-3,5-diamines 2 were evaluated while focusing on the inhibition of cyclin-dependent kinases (CDKs), but no significant results were obtained." . . "THE SYNTHESIS OF SOME DERIVATIVES BASED ON THE 4-BENZYL-1H-PYRAZOLE-3,5-DIAMINE CORE"@en . . . . "0385-5414" . "Jedin\u00E1k, L." . "P(GA204/08/0511), P(GA301/08/1649), Z(AV0Z50380511), Z(MSM6198959216)" . "Kry\u0161tof, Vladim\u00EDr" . . "Canka\u0159, Petr" . .