. "Petr\u00E1\u0161ek, Jan" . . "Cytokinin is an important regulator of plant growth and development. In Arabidopsis thaliana, the two component phosphorelay mediated through a family of histidine kinases and response regulators is recognized as the principal cytokinin signal transduction mechanism activating the complex transcriptional response to control various developmental processes. Here, we identified an alternative mode of cytokinin action that uses endocytic trafficking as a means to direct plant organogenesis. This activity occurs downstream of known cytokinin receptors but through a branch of the cytokinin signaling pathway that does not involve transcriptional regulation. We show that cytokinin regulates endocytic recycling of the auxin efflux carrier PINFORMED1 (PIN1) by redirecting it for lytic degradation in vacuoles. Stimulation of the lytic PIN1 degradation is specific mechanism to rapidly modulate the auxin distribution in cytokinin-mediated developmental processes." . "11"^^ . "RIV/61389030:_____/11:00366038!RIV12-AV0-61389030" . "Cytokinin Modulates Endocytic Trafficking of PIN1 Auxin Efflux Carrier to Control Plant Organogenesis" . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Benkov\u00E1, E." . . . "000296366000021" . . "1534-5807" . . "Kleine-Vehn, J." . "Friml, J." . "Bielach, A." . . "10.1016/j.devcel.2011.08.014" . . . . "21" . . "P(IAA601630703), P(LC06034), Z(AV0Z50380511), Z(MSM0021620858), Z(MSM0021622415)" . "Cytokinin Modulates Endocytic Trafficking of PIN1 Auxin Efflux Carrier to Control Plant Organogenesis"@en . . "Tanaka, H." . "[270FD6828D6A]" . . . "Cytokinin Modulates Endocytic Trafficking of PIN1 Auxin Efflux Carrier to Control Plant Organogenesis"@en . "Abas, L." . "auxin efflux; cytokinin; vacuoles; membrane trafficking"@en . "192633" . . . "RIV/61389030:_____/11:00366038" . "Cytokinin Modulates Endocytic Trafficking of PIN1 Auxin Efflux Carrier to Control Plant Organogenesis" . "9"^^ . "Cytokinin is an important regulator of plant growth and development. In Arabidopsis thaliana, the two component phosphorelay mediated through a family of histidine kinases and response regulators is recognized as the principal cytokinin signal transduction mechanism activating the complex transcriptional response to control various developmental processes. Here, we identified an alternative mode of cytokinin action that uses endocytic trafficking as a means to direct plant organogenesis. This activity occurs downstream of known cytokinin receptors but through a branch of the cytokinin signaling pathway that does not involve transcriptional regulation. We show that cytokinin regulates endocytic recycling of the auxin efflux carrier PINFORMED1 (PIN1) by redirecting it for lytic degradation in vacuoles. Stimulation of the lytic PIN1 degradation is specific mechanism to rapidly modulate the auxin distribution in cytokinin-mediated developmental processes."@en . "Duclercq, J." . "Developmental Cell" . "Abuzeineh, A." . "2"^^ . "Marhav\u00FD, P." . . "Pa\u0159ezov\u00E1, Mark\u00E9ta" . . . . . "4" .