"Hrstka, R." . . . "0956-3202" . "Hol\u010D\u00E1kov\u00E1, J." . . . "Olomoucine II, the most recent derivative of roscovitine, is an exceptionally potent pharmacological inhibitor of cyclin-dependent kinase activities. Here, we report that olomoucine II is also an effective antiviral agent. Olomoucine II inhibited replication of a broad range of wild-type human viruses, including herpes simplex virus, human adenovirus type-4 and human cytomegalovirus. Olomoucine II also inhibited replication of vaccinia virus and herpes simplex virus mutants resistant to conventional acyclovir treatment. This report is the first demonstration of a poxvirus being sensitive to a cyclin-dependent kinase inhibitor. The antiviral effects of olomoucine II could be observed at lower concentrations than with roscovitine, although both were short-term. A remarkable observation was that olomoucine II, when used in combination with the DNA polymerase inhibitor cidofovir, was able to almost completely eliminate the spread of infectious adenovirus type-4 progeny from infected cells." . . . . "RIV/61389030:_____/10:00359317" . . . "RIV/61389030:_____/10:00359317!RIV11-GA0-61389030" . "9"^^ . "Wang, E. C. Y." . . . . "Burget, J. J." . "3" . . "The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties"@en . . . "Vojte\u0161ek, B." . "20" . "2"^^ . "Toma\u0161ec, P." . . "Kry\u0161tof, Vladim\u00EDr" . "The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties" . "Cyclin-dependent Kinase; Olomoucine II; vaccinia"@en . "264009" . . . "Wilkinson, G. W. G." . . "The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties"@en . "10"^^ . . "The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties" . "Strnad, Miroslav" . "Olomoucine II, the most recent derivative of roscovitine, is an exceptionally potent pharmacological inhibitor of cyclin-dependent kinase activities. Here, we report that olomoucine II is also an effective antiviral agent. Olomoucine II inhibited replication of a broad range of wild-type human viruses, including herpes simplex virus, human adenovirus type-4 and human cytomegalovirus. Olomoucine II also inhibited replication of vaccinia virus and herpes simplex virus mutants resistant to conventional acyclovir treatment. This report is the first demonstration of a poxvirus being sensitive to a cyclin-dependent kinase inhibitor. The antiviral effects of olomoucine II could be observed at lower concentrations than with roscovitine, although both were short-term. A remarkable observation was that olomoucine II, when used in combination with the DNA polymerase inhibitor cidofovir, was able to almost completely eliminate the spread of infectious adenovirus type-4 progeny from infected cells."@en . "P(GA301/08/1649), P(LC06035), Z(AV0Z50380511), Z(MSM6198959216), Z(MZ0MOU2005)" . "[2BC58C2D76C6]" . "Antiviral Chemistry and Chemotherapy" . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" .