"5"^^ . "Possible anti-inflammatory effect of carvacrol was evaluated by in vitro cyclooxygenase-2 (COX-2) assay. Carvacrol inhibited production of prostaglandin E-2 catalysed by COX-2 with an IC50 value of 0.8 mu M what is practically the same concentration as the IC50 obtained for the standard inhibitors indomethacin and NS-398 with values of 0.7 mu M and 0.8 mu M, respectively. The COX-1 was inhibited approximately at the same rate (IC50 of 0.7 mu M for carvacrol), which suggests non-selective inhibition of both enzyme isoforms. The results of the study demonstrate possible anti-inflammatory potential of this compound due to the inhibition of inducible COX-2 isoform."@en . "Archives of Pharmacal Research" . . . "[3B2150C40963]" . . . . "RIV/61389030:_____/09:00335925" . "In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E-2 biosynthesis"@en . . . "Possible anti-inflammatory effect of carvacrol was evaluated by in vitro cyclooxygenase-2 (COX-2) assay. Carvacrol inhibited production of prostaglandin E-2 catalysed by COX-2 with an IC50 value of 0.8 mu M what is practically the same concentration as the IC50 obtained for the standard inhibitors indomethacin and NS-398 with values of 0.7 mu M and 0.8 mu M, respectively. The COX-1 was inhibited approximately at the same rate (IC50 of 0.7 mu M for carvacrol), which suggests non-selective inhibition of both enzyme isoforms. The results of the study demonstrate possible anti-inflammatory potential of this compound due to the inhibition of inducible COX-2 isoform." . "4"^^ . . "P\u0159ibylov\u00E1, Marie" . "1" . "Landa, P\u0159emysl" . "0253-6269" . "KR - Korejsk\u00E1 republika" . . "Koko\u0161ka, L." . . "Carvacrol; Cyclooxygenase; Prostaglandin"@en . "RIV/61389030:_____/09:00335925!RIV10-MSM-61389030" . . . . "4"^^ . "In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E-2 biosynthesis" . . . . "P(1P04OC926.001), P(GA525/08/1179), Z(AV0Z50380511)" . . "Van\u011Bk, Tom\u00E1\u0161" . "Mar\u0161\u00EDk, Petr" . . . "000262851700010" . "318913" . "In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E-2 biosynthesis" . "In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E-2 biosynthesis"@en . . "32" . .