. "Synthesis and biological activity of 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin" . "RIV/61389030:_____/06:00082517" . . . "41" . . . . "Kry\u0161tof, Vladim\u00EDr" . "Synthesis and biological activity of 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin"@en . "7"^^ . "RIV/61389030:_____/06:00082517!RIV07-AV0-61389030" . . "Havl\u00ED\u010Dek, Libor" . "Synt\u00E9za a biologick\u00E9 aktivity 8-azapurinov\u00E9ho a pyrazolo[4,3-d]pyrimidinov\u00E9ho analogu myoseverinu"@cs . . "6"^^ . . "Myoseverin; Purine; Tubulin"@en . "8"^^ . . . . "Byla porovn\u00E1na biologick\u00E1 aktivita zn\u00E1m\u00E9ho purinov\u00E9ho inhibitoru polymerace tubulinu \u2013 myoseverinu - a jeho 8-azapurinov\u00E9ho a pyrazolo[4,3-d]pyrimidinov\u00E9ho analogu v testu inhibice synt\u00E9zy tubulinu, inhibice CDK1 a pritin\u00E1dorov\u00E9 aktivit\u011B na lidsk\u00FDch n\u00E1dorov\u00FDch bun\u011B\u010Dn\u00FDch lini\u00EDch. Pyrazolo[4,3-d]pyrimidinov\u00FD isomer myoseverinu m\u00E1 vedle inhibi\u010Dn\u00EDch \u00FA\u010Dink\u016F na synt\u00E9zu tubulinu (IC50=16microM) i vlastnosti inhibitoru CDK1 (IC50=4microM)."@cs . . . "Synthesis and biological activity of 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin"@en . "1405;1411" . "The trisubstituted purine myoseverin has been recently identified as a novel inhibitor of microtubule assembly. To analyze the effects of modifying its heterocyclic skeleton, we prepared 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin and compared their biological activities. Rearrangement of nitrogen atoms in the heterocycle changes the affinity of the compounds to purified tubulin, as demonstrated by the results of polymerization assays, and affects the proliferation of cancer cell lines. Surprisingly, compound E2GG, a pyrazolo[4,3-d]pyrimidine analogue of myoseverin, displayed inhibitory activity towards both tubulin polymerization and the activity of cyclin-dependent kinases 1, 2 and 7. Such a dual specificity-inhibitor offers a starting point for developing a novel class of antiproliferative agents." . . "-" . "[3E7971297279]" . "FR - Francouzsk\u00E1 republika" . "Hlobilkov\u00E1, Alice" . "European Journal of Medicinal Chemistry" . . "Barbier, P." . . . . . . "The trisubstituted purine myoseverin has been recently identified as a novel inhibitor of microtubule assembly. To analyze the effects of modifying its heterocyclic skeleton, we prepared 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin and compared their biological activities. Rearrangement of nitrogen atoms in the heterocycle changes the affinity of the compounds to purified tubulin, as demonstrated by the results of polymerization assays, and affects the proliferation of cancer cell lines. Surprisingly, compound E2GG, a pyrazolo[4,3-d]pyrimidine analogue of myoseverin, displayed inhibitory activity towards both tubulin polymerization and the activity of cyclin-dependent kinases 1, 2 and 7. Such a dual specificity-inhibitor offers a starting point for developing a novel class of antiproliferative agents."@en . "Synthesis and biological activity of 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin" . "P(GA301/05/0418), P(GP204/03/D231), S, Z(AV0Z50380511), Z(MSM6198959216)" . . "Peyrot, V." . . "Paprsk\u00E1\u0159ov\u00E1, Martina" . "502772" . . "0223-5234" . "Strnad, Miroslav" . "Synt\u00E9za a biologick\u00E9 aktivity 8-azapurinov\u00E9ho a pyrazolo[4,3-d]pyrimidinov\u00E9ho analogu myoseverinu"@cs . . "Moravcov\u00E1, Daniela" .