"0"^^ . "2,6,8,9-Tetrasubstituted Purines as New CDK1 Inhibitors." . "0"^^ . "2993\u016F2996" . . . "RIV/61389030:_____/03:56033101!RIV/2004/GA0/A56004/N" . "Strnad, Miroslav" . . "Havl\u00ED\u010Dek, Libor" . . . . "7"^^ . "13" . "Purine inhibitors of cyclin-dependent kinases attract attention as potential anticancer drugs because their first representative roscovitine recently entered clinical trials. Although well described in terms of structure-activity relationships, we still present here a novel modification of the purine scaffold influencing their inhibitory properties. The introduced C-8 substituents, however, lowered the CDK inhibitory activity of roscovitine, whereas the antiproliferative potential of several derivatives remained high." . . . "[C7817E8D3077]" . "Moravec, Ji\u0159\u00ED" . . "Fuksov\u00E1, K." . . "10"^^ . . . "2,6,8,9-Tetrasubstituted Purines as New CDK1 Inhibitors."@en . "Lenobel, Ren\u00E9" . "Moravcov\u00E1, Daniela" . . "4"^^ . . "2,6,8,9-Tetrasubstituted Purines as New CDK1 Inhibitors." . . "636799" . "Kry\u0161tof, Vladim\u00EDr" . . . . "RIV/61389030:_____/03:56033101" . . "18" . "Bioorganic and Medicinal Chemistry Letters" . "P(GA301/02/0475), P(KJB6137301), Z(AV0Z5020903), Z(AV0Z5038910), Z(MSM 153100007)" . "Hanu\u0161, Jan" . . "0960-894X" . "Kuzma, Marek" . "Otyepka, M." . . "2,6,8,9-Tetrasubstituted Purines as New CDK1 Inhibitors."@en . "Purine inhibitors of cyclin-dependent kinases attract attention as potential anticancer drugs because their first representative roscovitine recently entered clinical trials. Although well described in terms of structure-activity relationships, we still present here a novel modification of the purine scaffold influencing their inhibitory properties. The introduced C-8 substituents, however, lowered the CDK inhibitory activity of roscovitine, whereas the antiproliferative potential of several derivatives remained high."@en . . . . "NL - Nizozemsko" . . . "Purine inhibitors; cyclin-dependent kinases; roscovitine"@en .