"1" . "638512" . . . . "2"^^ . . . . "3"^^ . "0"^^ . "141;146" . "0"^^ . "Antiapoptotic and Proapoptotic Action of Various Amino Acids and Analogs in Starving MOLT-4 Cells." . . . . . "Eckschlanger, T." . "[7FF2F47C4710]" . . "Archives of Biochemistry and Biophysics" . "Antiapoptotic and Proapoptotic Action of Various Amino Acids and Analogs in Starving MOLT-4 Cells."@en . "6"^^ . "Antiapoptotic and Proapoptotic Action of Various Amino Acids and Analogs in Starving MOLT-4 Cells." . "amino acids; MOLT-4; apoptosis"@en . . "0003-9861" . . "NL - Nizozemsko" . . "Fismolov\u00E1, Ivana" . "RIV/61389030:_____/02:56023002" . "Antiapoptotic and Proapoptotic Action of Various Amino Acids and Analogs in Starving MOLT-4 Cells."@en . . "This study is based on our previous findings showing that certain amino acids may protect hybridoma cells against starvation-induced apoptosis. In the present work we have screened 44 amino acids and analogs for their capacity of modulating apoptosis in human T-lymphoblastic leukemia cell line MOLT-4 exposed to starvation in a nutrient-poor medium. The panel of tested substances was found to contain not only compounds with antiapoptotic activity (e.g., L-glutamine, L-histidine, glycine, L-proline, and L-2-aminopentanoic acid), but also compounds with proapoptotic activity (e.g., L-phenylalanine, L-tryptophan, L-arginine, and L-2-aminohexanoic acid). The apoptosis-modulating effects were dependent on fine details of the structure of the compounds. A switch from antiapoptotic activity to proapoptotic activity was found between 6-ami-nohexanoic acid and 7-aminoheptanoic acid, as well as between L-2-aminopentanoic acid and L-2-aminohex-anoic acid. D-amino acids tested were without effect." . . . "P(OC 844.10), Z(AV0Z5038910)" . "Fran\u011Bk, Franti\u0161ek" . "This study is based on our previous findings showing that certain amino acids may protect hybridoma cells against starvation-induced apoptosis. In the present work we have screened 44 amino acids and analogs for their capacity of modulating apoptosis in human T-lymphoblastic leukemia cell line MOLT-4 exposed to starvation in a nutrient-poor medium. The panel of tested substances was found to contain not only compounds with antiapoptotic activity (e.g., L-glutamine, L-histidine, glycine, L-proline, and L-2-aminopentanoic acid), but also compounds with proapoptotic activity (e.g., L-phenylalanine, L-tryptophan, L-arginine, and L-2-aminohexanoic acid). The apoptosis-modulating effects were dependent on fine details of the structure of the compounds. A switch from antiapoptotic activity to proapoptotic activity was found between 6-ami-nohexanoic acid and 7-aminoheptanoic acid, as well as between L-2-aminopentanoic acid and L-2-aminohex-anoic acid. D-amino acids tested were without effect."@en . "398" . "RIV/61389030:_____/02:56023002!RIV/2003/AV0/A56003/N" . .