"NL - Nizozemsko" . "A new type of irreversibly reductively biodegradable hydrogel"@en . "[A49201EDF047]" . . . . "96" . "Polymer Degradation and Stability" . "A new type of irreversibly reductively biodegradable hydrogel" . "A new type of irreversibly reductively biodegradable hydrogel"@en . "183982" . "P\u0159\u00E1dn\u00FD, Martin" . "Reductively biodegradable hydrogels based on poly[N-(2-hydroxypropyl)methacrylamide] crosslinked with N-[3-(methacryloylamino)propyl] -6-{[5-({[3-(methacryloylamino)propyl]amino}carbonyl)-2-pyridyl]disulfanyl}nicotinamide intended for tissue engineering were synthesized and characterized. The rate of irreversible reductive degradation with thiol l-cysteine (a model of human body where several thiols are present in extracellular space) was studied using several l-cysteine concentrations. The mechanism of the irreversible reductive bond cleavage in the crosslinker structure was confirmed on a low-molecular-weight model. The hydrogel is stable during storage in phosphate buffered saline and is degraded relatively quickly in a concentration-dependent manner after addition of l-cysteine to the surrounding medium."@en . "A new type of irreversibly reductively biodegradable hydrogel" . "RIV/61389013:_____/11:00359453!RIV12-AV0-61389013" . . "Reductively biodegradable hydrogels based on poly[N-(2-hydroxypropyl)methacrylamide] crosslinked with N-[3-(methacryloylamino)propyl] -6-{[5-({[3-(methacryloylamino)propyl]amino}carbonyl)-2-pyridyl]disulfanyl}nicotinamide intended for tissue engineering were synthesized and characterized. The rate of irreversible reductive degradation with thiol l-cysteine (a model of human body where several thiols are present in extracellular space) was studied using several l-cysteine concentrations. The mechanism of the irreversible reductive bond cleavage in the crosslinker structure was confirmed on a low-molecular-weight model. The hydrogel is stable during storage in phosphate buffered saline and is degraded relatively quickly in a concentration-dependent manner after addition of l-cysteine to the surrounding medium." . . . "0141-3910" . . "4"^^ . . . . . "biodegradable hydrogel; disulfide; L-cysteine"@en . "Vetr\u00EDk, Miroslav" . . . . . . . "4"^^ . "Vetr\u00EDk, Miroslav" . "5" . "P(1M0538), P(GAP108/10/1560), P(GPP207/10/P054), Z(AV0Z40500505)" . . "10.1016/j.polymdegradstab.2011.01.037" . "Mich\u00E1lek, Ji\u0159\u00ED" . "000290078200021" . . "6"^^ . . "RIV/61389013:_____/11:00359453" . . "Hrub\u00FD, Martin" . .