. . . "9" . "RIV/61389013:_____/10:00348858" . "P(1M0505), Z(AV0Z40500505)" . "12" . . "268873" . "\u0160ubr, Vladim\u00EDr" . "Long-circulating and passively tumor-targeted polymer-drug conjugates improve the efficacy and reduce the toxicity of radiochemotherapy"@en . . "Long-circulating and passively tumor-targeted polymer-drug conjugates improve the efficacy and reduce the toxicity of radiochemotherapy" . . . "RIV/61389013:_____/10:00348858!RIV11-MSM-61389013" . "Kiessling, F." . . "Advanced Engineering Materials" . . . "Long-circulating and passively tumor-targeted polymer-drug conjugates improve the efficacy and reduce the toxicity of radiochemotherapy"@en . . . . "Using HPMA copolymers as a model drug carrier, and doxorubicin and gemcitabine as model drugs, we here show that long-circulating and passively tumor-targeted polymeric drug carriers interact synergistically with radiotherapy, with radiotherapy improving the tumor accumulation of the copolymers, and with the copolymers improving both the efficacy and the toxicity of radiochemotherapy. These findings indicate that \u201Ccarrier-based radiochemotherapy holds significant potential for improving the treatment of advanced solid malignancies." . "Peschke, P." . . "Using HPMA copolymers as a model drug carrier, and doxorubicin and gemcitabine as model drugs, we here show that long-circulating and passively tumor-targeted polymeric drug carriers interact synergistically with radiotherapy, with radiotherapy improving the tumor accumulation of the copolymers, and with the copolymers improving both the efficacy and the toxicity of radiochemotherapy. These findings indicate that \u201Ccarrier-based radiochemotherapy holds significant potential for improving the treatment of advanced solid malignancies."@en . "Hennink, W. E." . . "Lammers, T." . "Ulbrich, Karel" . "[CE736DA9EAFC]" . "2"^^ . "HPMA copolymers; targeting; tumor targeting"@en . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "Long-circulating and passively tumor-targeted polymer-drug conjugates improve the efficacy and reduce the toxicity of radiochemotherapy" . "000283996400005" . . "Storm, G." . "Huber, P. E." . . "8"^^ . . "1438-1656" . "9"^^ .