"B\u011B\u017En\u00FD vir\u00E1ln\u00ED tropismus m\u016F\u017Ee b\u00FDt potla\u010Den modifikac\u00ED povrchu viru reaktivn\u00EDmi hydrofiln\u00EDmi polymery, kter\u00E9 z\u00E1rove\u0148 zav\u00E1d\u011Bj\u00ED nov\u00E9 specifick\u00E9 ligandy, a t\u00EDm umo\u017E\u0148uj\u00ED retargeting k zvolen\u00FDm receptor\u016Fm. Adenovirus modifikovan\u00FD polymerem s mEGF ztratil sv\u016Fj \u0161irok\u00FD tropismus a infikoval bu\u0148ky selektivn\u011B p\u0159es EGF receptory (EGFR)."@cs . "2" . . . . "252748600004" . "Normal virus tropism can be ablated by physically shielding the virus surface with reactive hydrophilic polymers and that linkage of novel ligands enables virus retargeting through chosen receptors. The resulting mEGF-polymer coated adenovirus lost its normal broad tropism and transduced cells selectively via the EGF receptor (EGFR)." . "adenovirus; gene delivery; N-(2-hydroxypropyl)methacrylamide"@en . . "1525-0016" . . "Morrison, J." . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Green, N." . "2"^^ . . "Normal virus tropism can be ablated by physically shielding the virus surface with reactive hydrophilic polymers and that linkage of novel ligands enables virus retargeting through chosen receptors. The resulting mEGF-polymer coated adenovirus lost its normal broad tropism and transduced cells selectively via the EGF receptor (EGFR)."@en . . "Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor"@en . "RIV/61389013:_____/08:00311069!RIV09-AV0-61389013" . "Vir\u00E1ln\u00ED terapie rakoviny ovari\u00ED polymerem modifikovan\u00FDm adenovirem sm\u011Brovan\u00FDm k receptor\u016Fm epiderm\u00E1ln\u00EDho r\u016Fstov\u00E9ho faktoru"@cs . . . "Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor"@en . "Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor" . . "Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor" . "Fisher, K." . "402721" . "Molecular Therapy" . "8"^^ . . "[64B7A51FAD41]" . "Vir\u00E1ln\u00ED terapie rakoviny ovari\u00ED polymerem modifikovan\u00FDm adenovirem sm\u011Brovan\u00FDm k receptor\u016Fm epiderm\u00E1ln\u00EDho r\u016Fstov\u00E9ho faktoru"@cs . "Kehoe, S." . "\u0160ubr, Vladim\u00EDr" . "16" . . "RIV/61389013:_____/08:00311069" . . . . "8"^^ . "Briggs, S. S." . "Seymour, L. W." . . "Z(AV0Z40500505)" . "Ulbrich, Karel" .