. "Byly p\u0159ipraveny a charakterizov\u00E1ny hydrofiln\u00ED protin\u00E1dorov\u00E1 polymern\u00ED l\u00E9\u010Diva zalo\u017Een\u00E1 na b\u00E1zi kopolymer\u016F HPMA nesouc\u00EDch sm\u011Bruj\u00EDc\u00ED nonapeptidovou sekvenci a cytostatikum doxorubicin. Cytostatikum bylo nav\u00E1z\u00E1no na polymern\u00EDm nosi\u010Di hydrazonovou vazbou, kter\u00E1 je stabiln\u00ED p\u0159i pH 7.4 (krevn\u00ED \u0159e\u010Di\u0161t\u011B) a \u0161t\u011Bpiteln\u00E1 p\u0159i pH 5 (endosomy)."@cs . . "Polymer-doxorubicin conjugate with a synthetic peptide ligand targeted on prostate tumor"@en . "4"^^ . . . "6" . "3"^^ . "[48A148541B10]" . . "Pechar, Michal" . "Polymer-doxorubicin conjugate with a synthetic peptide ligand targeted on prostate tumor" . . "Polymern\u00ED konjug\u00E1ty s doxorubicinem a syntetick\u00FDm nonapeptidem jako sm\u011Bruj\u00EDc\u00ED jednotkou do n\u00E1dor\u016F prostaty."@cs . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "Polymern\u00ED konjug\u00E1ty s doxorubicinem a syntetick\u00FDm nonapeptidem jako sm\u011Bruj\u00EDc\u00ED jednotkou do n\u00E1dor\u016F prostaty."@cs . "19"^^ . . . . "Ulbrich, Karel" . "P(GA204/05/2255), Z(AV0Z40500505)" . "Pola, Robert" . "RIV/61389013:_____/07:00091111!RIV08-AV0-61389013" . "Fabra, A." . . "602;620" . . . "442189" . . "drug delivery systems; drug research; hydrazones"@en . "Journal of Bioactive and Compatible Polymers" . . "0883-9115" . . "Polymer-doxorubicin conjugate with a synthetic peptide ligand targeted on prostate tumor"@en . "A water-soluble anti-tumor polymeric drug based on HPMA copolymer bearing a targeting nonapeptide ligand was synthesized and characterized. The cytostatic drug doxorubicin was attached to the copolymer via the hydrazone bond relatively stable in a buffer of pH 7.4 modeling conditions in blood circulation and cleavable at pH 5 corresponding to endosomes."@en . "RIV/61389013:_____/07:00091111" . . "22" . "A water-soluble anti-tumor polymeric drug based on HPMA copolymer bearing a targeting nonapeptide ligand was synthesized and characterized. The cytostatic drug doxorubicin was attached to the copolymer via the hydrazone bond relatively stable in a buffer of pH 7.4 modeling conditions in blood circulation and cleavable at pH 5 corresponding to endosomes." . . "Polymer-doxorubicin conjugate with a synthetic peptide ligand targeted on prostate tumor" . .