. "Systemic delivery of adenoviral vectors is a major goal in cancer gene therapy. Surface-masking technique based on multivalent HPMA copolymers was used to ablate all pathways of receptor-mediated infection. Polymer coating of adenovirus gave at least 100-fold decreased unwanted hepatic transgene expression and resulted in prolonged blood circulation and improved bioavailability of the adenovirus." . "Extended plasma circulation time and decreased toxicity of polymer-coated adenovirus" . "Prodlou\u017Een\u00E1 doba cirkulace v plazm\u011B a sn\u00ED\u017Een\u00E1 toxicita polymerem kryt\u00FDch adenovir\u016F"@cs . . "11" . "Hermiston, T." . . . "Hale, A. B." . . "1"^^ . "Extended plasma circulation time and decreased toxicity of polymer-coated adenovirus"@en . . "Extended plasma circulation time and decreased toxicity of polymer-coated adenovirus"@en . . "Herbert, C. W." . "Prodlou\u017Een\u00E1 doba cirkulace v plazm\u011B a sn\u00ED\u017Een\u00E1 toxicita polymerem kryt\u00FDch adenovir\u016F"@cs . "Extended plasma circulation time and decreased toxicity of polymer-coated adenovirus" . "RIV/61389013:_____/04:00101438" . "10"^^ . "Gene Therapy" . . "8"^^ . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Systemick\u00E1 aplikace adenovir\u00E1ln\u00EDch vektor\u016F je jedn\u00EDm z hlavn\u00EDch c\u00EDl\u016F genov\u00E9 terapie. Technika maskov\u00E1n\u00ED povrchu multivalentn\u00EDm HPMA kopolymerem byla u\u017Eita k odstran\u011Bn\u00ED v\u0161ech cest receptorem zprost\u0159edkovan\u00E9 infekce. Maskov\u00E1n\u00ED polymerem vedlo k p\u0159inejmen\u0161\u00EDm 100n\u00E1sobn\u00E9mu poklesu ne\u017E\u00E1douc\u00ED hepatick\u00E9 transgenick\u00E9 exprese a vy\u00FAstilo v prodlou\u017Eenou cirkulaci v krvi a zlep\u0161enou biologickou dostupnost adenoviru."@cs . "adenovirus;gene delivery;polymer coating"@en . "Seymour, L. W." . "Systemic delivery of adenoviral vectors is a major goal in cancer gene therapy. Surface-masking technique based on multivalent HPMA copolymers was used to ablate all pathways of receptor-mediated infection. Polymer coating of adenovirus gave at least 100-fold decreased unwanted hepatic transgene expression and resulted in prolonged blood circulation and improved bioavailability of the adenovirus."@en . . . . . "16" . "0969-7128" . . "Hale, S. J." . "RIV/61389013:_____/04:00101438!RIV/2005/AV0/A55005/N" . "Mautner, V." . "1256;1263" . "Ulbrich, Karel" . "P(KSK4055109), Z(AV0Z4050913)" . "Harkins, R." . . . "Fisher, K. D." . "563943" . "Green, N. K." . "[3B5E64FBA43F]" . . .