"Polykationty obsahuj\u00EDc\u00ED prim\u00E1rn\u00ED a terci\u00E1rn\u00ED amino a kvartern\u00ED amoniov\u00E9 skupiny tvo\u0159\u00ED stabiln\u00ED komplexy s DNA pouze v \u010Dist\u00E9 vod\u011B. S rostouc\u00ED koncentrac\u00ED chloridu sodn\u00E9ho doch\u00E1zelo k disociaci polyplex\u016F a uvoln\u011Bn\u00ED DNA. Stabilita komplex\u016F klesala v po\u0159ad\u00ED prim\u00E1rn\u00ED > sekund\u00E1rn\u00ED > terci\u00E1rn\u00ED > kvartern\u00ED amoniov\u00E1 skupina. V\u00FDsledky po\u010D\u00EDta\u010Dov\u00E9ho modelov\u00E1n\u00ED interakc\u00ED oligokationtu s modelem \u0159et\u011Bzce DNA byly v dobr\u00E9m souhlasu s experiment\u00E1ln\u00EDmi daty."@cs . "polycation-DNA complexes;gene delivery;quantum mechanical calculations"@en . . . "Polycations containing primary and tertiary amino and quaternary ammonium groups formed stable complexes with DNA only in pure water. Increasing concentration of sodium chloride in the saline solution resulted in dissociation, decomposition of the polyplexes and release of incorporated DNA. Stability of the complexes decreased depending on polycation substituent as follows: primary amine > secondary amine > tertiary amine >quaternary ammonium group. Results of computer modeling of the interaction of the oligocations with a model DNA chain were in good agreement with the experimental data."@en . "1211-5894" . "Stability of polycation-DNA complexes: comparison of computer model and experimental data" . "4"^^ . . "Polycations containing primary and tertiary amino and quaternary ammonium groups formed stable complexes with DNA only in pure water. Increasing concentration of sodium chloride in the saline solution resulted in dissociation, decomposition of the polyplexes and release of incorporated DNA. Stability of the complexes decreased depending on polycation substituent as follows: primary amine > secondary amine > tertiary amine >quaternary ammonium group. Results of computer modeling of the interaction of the oligocations with a model DNA chain were in good agreement with the experimental data." . "11" . "Stability of polycation-DNA complexes: comparison of computer model and experimental data"@en . "Materials Structure" . . . . . . "Stabilita komplex\u016F polykationt-DNA: porovn\u00E1n\u00ED po\u010D\u00EDta\u010Dov\u00E9ho modelu a experiment\u00E1ln\u00EDch dat"@cs . "587703" . "Stability of polycation-DNA complexes: comparison of computer model and experimental data" . "3;6" . "Huml, Karel" . "5"^^ . "RIV/61389013:_____/04:00101286" . . . "4"^^ . . "RIV/61389013:_____/04:00101286!RIV/2005/AV0/A55005/N" . "Kabel\u00E1\u010D, Martin" . . . . . "Stabilita komplex\u016F polykationt-DNA: porovn\u00E1n\u00ED po\u010D\u00EDta\u010Dov\u00E9ho modelu a experiment\u00E1ln\u00EDch dat"@cs . "Dybal, Ji\u0159\u00ED" . "1" . "P(KSK4055109), Z(AV0Z4050913)" . . "CZ - \u010Cesk\u00E1 republika" . . "Ulbrich, Karel" . . . "Reschel, Tom\u00E1\u0161" . "[B82FBAAB526B]" . . "Stability of polycation-DNA complexes: comparison of computer model and experimental data"@en .