"Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates" . . "Olejniczak, A. B." . "Thymidine conjugates containing metallacarborane, {8-[5-(N-3-thymidine)-3-oxa-pentoxy]-3-cobalt bis(1,2-dicarbollide)}(-) (5) and {8-[5-(O-4-thymidine)-3-oxa-pentoxy]-3-cobalt bis(1,2-dicarbollide)}(-) (6) ions and several simple [3-cobalt bis(1,2-dicarbollide)]- ion (1) derivatives have been studied as potential boron carriers for BNCT. Compound 6 and some nonnucleoside derivatives of 1 were not toxic above 100 mu M. The partition coefficient for both metallacarborane bearing thymidine conjugates 5 and 6 was more than 500 times higher than that of unmodified nucleoside. The cellular uptake studies showed accumulation of compounds 6 in V79 Chinese hamster cells but not of compound 5. The low toxicity of conjugate type of 6 together with its high partition coefficient suggest that judicially designed derivatives of metallacarboranes can be considered as potential boron carriers for BNCT." . "K nov\u00FDm b\u00F3rov\u00FDm nosi\u010D\u016Fm pro bor- neutron z\u00E1chytovou terapii: metallakarborany a jejich nukleosidov\u00E9 konjug\u00E1ty"@cs . "4168;4175" . . "[375A1FC7FCF0]" . "Gabel, D." . . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "Thymidine conjugates containing metallacarborane, {8-[5-(N-3-thymidine)-3-oxa-pentoxy]-3-cobalt bis(1,2-dicarbollide)}(-) (5) and {8-[5-(O-4-thymidine)-3-oxa-pentoxy]-3-cobalt bis(1,2-dicarbollide)}(-) (6) ions and several simple [3-cobalt bis(1,2-dicarbollide)]- ion (1) derivatives have been studied as potential boron carriers for BNCT. Compound 6 and some nonnucleoside derivatives of 1 were not toxic above 100 mu M. The partition coefficient for both metallacarborane bearing thymidine conjugates 5 and 6 was more than 500 times higher than that of unmodified nucleoside. The cellular uptake studies showed accumulation of compounds 6 in V79 Chinese hamster cells but not of compound 5. The low toxicity of conjugate type of 6 together with its high partition coefficient suggest that judicially designed derivatives of metallacarboranes can be considered as potential boron carriers for BNCT."@en . "Studzinska, M." . "Seekamp, P." . "molecular structure; boron neutron capture therapy"@en . . "Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates"@en . "K nov\u00FDm b\u00F3rov\u00FDm nosi\u010D\u016Fm pro bor- neutron z\u00E1chytovou terapii: metallakarborany a jejich nukleosidov\u00E9 konjug\u00E1ty."@cs . . "Paradowska, E." . "Bioorganic Medical Chemistry" . . "13" . . . "Schinazi, R. F." . "Schussler, U." . "0968-0896" . "9"^^ . "Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates" . . . "8"^^ . . "Lesnikowski, Z. J." . "546966" . "RIV/61388980:_____/05:00029921" . . "K nov\u00FDm b\u00F3rov\u00FDm nosi\u010D\u016Fm pro bor- neutron z\u00E1chytovou terapii: metallakarborany a jejich nukleosidov\u00E9 konjug\u00E1ty"@cs . "Z(AV0Z40320502)" . "RIV/61388980:_____/05:00029921!RIV06-AV0-61388980" . "Ple\u0161ek, Jarom\u00EDr" . "13" . "1"^^ . . "Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates"@en .