. "RIV/61388971:_____/14:00435748" . "Kudanga, T." . . "Enzymatic oxidative dimerization of silymarin flavonolignans"@en . "NL - Nizozemsko" . "6"^^ . . . "Vav\u0159\u00EDkov\u00E1, Eva" . "10.1016/j.molcatb.2014.07.012" . "14814" . . . "K\u0159en, Vladim\u00EDr" . "1381-1177" . "Enzymatic oxidative dimerization of silymarin flavonolignans" . "NOV 2014" . . . . . "[F1460638D00A]" . "Enzymatic oxidative dimerization of silymarin flavonolignans"@en . "Biedermann, David" . . "Silybin dimers; Silydianin dimer; Silymarin"@en . . . . . "Gavezzotti, P." . "Kuzma, Marek" . . "I, P(GP14-14373P), P(LD13041)" . "Dimerization of phenolic compounds can potentially enhance their biological (antioxidant) activity. We present here the selective oxidative dimerization of several flavonolignans from Silybum marianum seed extract, namely, silybin A (1a), silybin B (1b), silychristin (3), and silydianin (4) catalyzed by a laccase from Trametes versicolor. Selective benzylation of C-7 OH group of both silybins ensured the priority of the dimerization reaction, avoiding thus polymerization. C-C homodimers connected via E-rings of silybin A and B and silydianin dimers were successfully isolated after respective debenzylation. On the contrary, dimerization of 7-O-benzyl silychristin afforded a complex, inseparable mixture of the products. All isolated flavonolignan dimers exhibited significantly improved 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity compared to their monomers and, therefore, seem to be promising for further biological studies" . . . . "109" . "5"^^ . "000343854100004" . "Fronza, G." . . "Dimerization of phenolic compounds can potentially enhance their biological (antioxidant) activity. We present here the selective oxidative dimerization of several flavonolignans from Silybum marianum seed extract, namely, silybin A (1a), silybin B (1b), silychristin (3), and silydianin (4) catalyzed by a laccase from Trametes versicolor. Selective benzylation of C-7 OH group of both silybins ensured the priority of the dimerization reaction, avoiding thus polymerization. C-C homodimers connected via E-rings of silybin A and B and silydianin dimers were successfully isolated after respective debenzylation. On the contrary, dimerization of 7-O-benzyl silychristin afforded a complex, inseparable mixture of the products. All isolated flavonolignan dimers exhibited significantly improved 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity compared to their monomers and, therefore, seem to be promising for further biological studies"@en . "9"^^ . "Riva, S." . "Valentov\u00E1, Kate\u0159ina" . "Enzymatic oxidative dimerization of silymarin flavonolignans" . "Journal of Molecular Catalysis B-Enzymatic" . . "RIV/61388971:_____/14:00435748!RIV15-GA0-61388971" .