"RIV/61388971:_____/13:00395423" . . . "Biotechnology Advances" . "Van\u011Bk, Ond\u0159ej" . . "RIV/61388971:_____/13:00395423!RIV14-MSM-61388971" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . . . . "Nov\u00E1k, Petr" . "000315761200003" . "[CCF905E24AF2]" . "10.1016/j.biotechadv.2012.03.008" . . "Bezou\u0161ka, Karel" . "21"^^ . . . "The glycan code of glycoproteins can be conceptually defined at molecular level by the sequence of well characterized glycans attached to evolutionarily predetermined amino acids along the polypeptide chain. Functional consequences of protein glycosylation are numerous, and include a hierarchy of properties from general physicochemical characteristics such as solubility, stability and protection of the polypeptide from the environment up to specific glycan interactions. Definition of the glycan code for glycoproteins has been so far hampered by the lack of chemically defined glycoprotein glycoforms that proved to be extremely difficult to purify from natural sources, and the total chemical synthesis of which has been hitherto possible only for very small molecular species" . . . "64255" . . . . . . "0734-9750" . . "Carbohydrate synthesis and biosynthesis technologies for cracking of the glycan code: Recent advances" . . "Carbohydrate synthesis and biosynthesis technologies for cracking of the glycan code: Recent advances" . "6"^^ . "Carbohydrate synthesis and biosynthesis technologies for cracking of the glycan code: Recent advances"@en . . "Bojarov\u00E1, Pavla" . "Weignerov\u00E1, Lenka" . . "I, P(7E11011), P(GA303/09/0477), P(GAP207/10/0321), P(GD305/09/H008), P(LD13041)" . "Carbohydrate synthesis and biosynthesis technologies for cracking of the glycan code: Recent advances"@en . "1" . "The glycan code of glycoproteins can be conceptually defined at molecular level by the sequence of well characterized glycans attached to evolutionarily predetermined amino acids along the polypeptide chain. Functional consequences of protein glycosylation are numerous, and include a hierarchy of properties from general physicochemical characteristics such as solubility, stability and protection of the polypeptide from the environment up to specific glycan interactions. Definition of the glycan code for glycoproteins has been so far hampered by the lack of chemically defined glycoprotein glycoforms that proved to be extremely difficult to purify from natural sources, and the total chemical synthesis of which has been hitherto possible only for very small molecular species"@en . . "6"^^ . . "31" . . . . "Cellular factories; Complex carbohydrates; Glycodrugs"@en . "Mr\u00E1zek, Hynek" .