"RIV/61388971:_____/11:00369663" . "High-molecular polymeric carriers of medicaments derived from dendrimers and conjugates thereof with medicaments for treating especially solid tumors"@en . "\u00DAstav makromolekul\u00E1rn\u00ED chemie AV \u010CR, v. v. i. - Mikrobiologick\u00FD \u00FAstav AV \u010CR, v. v. i" . . "5"^^ . . "http://spisy.upv.cz/Patents/FullDocuments/302/302830.pdf" . . "Vysokomolekul\u00E1rn\u00ED polymern\u00ED nosi\u010De l\u00E9\u010Div odvozen\u00E9 od dendrimer\u016F a jejich konjug\u00E1ty s l\u00E9\u010Divy pro l\u00E9\u010Dbu zejm\u00E9na pevn\u00FDch n\u00E1dor\u016F" . . . "polymer conjugates; doxorubicin; drug targeting"@en . "2011-10-20+02:00"^^ . "Strohalm, Ji\u0159\u00ED" . . "P(IAA400500806), P(KAN200200651), Z(AV0Z40500505), Z(AV0Z50200510)" . . . . . . "Prague" . "Vysokomolekul\u00E1rn\u00ED polymern\u00ED nosi\u010De l\u00E9\u010Div odvozen\u00E9 od dendrimer\u016F a jejich konjug\u00E1ty s l\u00E9\u010Divy pro l\u00E9\u010Dbu zejm\u00E9na pevn\u00FDch n\u00E1dor\u016F"@cs . "RIV/61388971:_____/11:00369663!RIV12-AV0-61388971" . . "302830" . "High-molecular polymeric carriers of medicaments derived from dendrimers and conjugates thereof with medicaments for treating especially solid tumors"@en . "Chytil, Petr" . . . "Vysokomolekul\u00E1rn\u00ED polymern\u00ED nosi\u010De l\u00E9\u010Div odvozen\u00E9 od dendrimer\u016F a jejich konjug\u00E1ty s l\u00E9\u010Divy pro l\u00E9\u010Dbu zejm\u00E9na pevn\u00FDch n\u00E1dor\u016F" . "The present invention relates to water-soluble high-molecular polymeric carriers of medicaments and their conjugates with medicaments, derived from dendrimers based on poly (amidoamine) and 2,2-bis(hydroxymethyl)propionic dendrimer, the amino and hydroxy end groups of which are attached to semitelechelic copolymers of N-(2 hydroxypropyl)methacrylamide (HPMA) through the mediation of biodegradable spacers. The polymer carriers and conjugates of the present invention enable targeted transport notably of anticancer medicaments into solid tumors in which biodegradation, the associated controlled drug release and subsequent elimination of polymer carrier from the organism are provided. The efficiency of the polymer carrier conjugated with a cancerostatic is directed to targeted therapy of human tumors."@en . . "[7F6B75F5CCD5]" . "240265" . . "Vysokomolekul\u00E1rn\u00ED polymern\u00ED nosi\u010De l\u00E9\u010Div odvozen\u00E9 od dendrimer\u016F a jejich konjug\u00E1ty s l\u00E9\u010Divy pro l\u00E9\u010Dbu zejm\u00E9na pevn\u00FDch n\u00E1dor\u016F"@cs . . . . "\u0158\u00EDhov\u00E1, Blanka" . "P\u0159edlo\u017Een\u00E9 \u0159e\u0161en\u00ED se t\u00FDk\u00E1 vysokomolekul\u00E1rn\u00EDch vodorozpustn\u00FDch polymern\u00EDch nosi\u010D\u016F l\u00E9\u010Div a jejich konjug\u00E1t\u016F s l\u00E9\u010Divy, odvozen\u00FDch od dendrimer\u016F na b\u00E1zi poly(amidoaminov\u00E9ho) a 2,2-bis(hydroxymethyl)propionov\u00E9ho dendrimeru, na jejich\u017E koncov\u00E9 amino nebo hydroxyskupiny jsou p\u0159es konce \u0159et\u011Bzce nav\u00E1z\u00E1ny prost\u0159ednictv\u00EDm biodegradovateln\u00FDch spojek semitelechelick\u00E9 kopolymery N-(2-hydroxypropyl)methakrylamidu (HPMA). Tyto nosi\u010De a konjug\u00E1ty umo\u017E\u0148uj\u00ED c\u00EDlen\u00FD transport zejm\u00E9na protin\u00E1dorov\u00FDch l\u00E9\u010Div do pevn\u00FDch n\u00E1dor\u016F, u kter\u00FDch je zaji\u0161t\u011Bna biodegradabilita, a s t\u00EDm spojen\u00E9 \u0159\u00EDzen\u00E9 uvol\u0148ov\u00E1n\u00ED l\u00E9\u010Diva a n\u00E1sledn\u00E1 eliminace polymern\u00EDho nosi\u010De z organizmu. \u00DA\u010Dinek polymern\u00EDho nosi\u010De konjugovan\u00E9ho s kancerostatikem je zam\u011B\u0159en na c\u00EDlenou terapii n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED v hum\u00E1nn\u00ED medic\u00EDn\u011B."@cs . . "1"^^ . . "Ulbrich, Karel" . "Etrych, Tom\u00E1\u0161" . "\u00DA\u0159ad pr\u016Fmyslov\u00E9ho vlastnictv\u00ED" . . . "P\u0159edlo\u017Een\u00E9 \u0159e\u0161en\u00ED se t\u00FDk\u00E1 vysokomolekul\u00E1rn\u00EDch vodorozpustn\u00FDch polymern\u00EDch nosi\u010D\u016F l\u00E9\u010Div a jejich konjug\u00E1t\u016F s l\u00E9\u010Divy, odvozen\u00FDch od dendrimer\u016F na b\u00E1zi poly(amidoaminov\u00E9ho) a 2,2-bis(hydroxymethyl)propionov\u00E9ho dendrimeru, na jejich\u017E koncov\u00E9 amino nebo hydroxyskupiny jsou p\u0159es konce \u0159et\u011Bzce nav\u00E1z\u00E1ny prost\u0159ednictv\u00EDm biodegradovateln\u00FDch spojek semitelechelick\u00E9 kopolymery N-(2-hydroxypropyl)methakrylamidu (HPMA). Tyto nosi\u010De a konjug\u00E1ty umo\u017E\u0148uj\u00ED c\u00EDlen\u00FD transport zejm\u00E9na protin\u00E1dorov\u00FDch l\u00E9\u010Div do pevn\u00FDch n\u00E1dor\u016F, u kter\u00FDch je zaji\u0161t\u011Bna biodegradabilita, a s t\u00EDm spojen\u00E9 \u0159\u00EDzen\u00E9 uvol\u0148ov\u00E1n\u00ED l\u00E9\u010Diva a n\u00E1sledn\u00E1 eliminace polymern\u00EDho nosi\u010De z organizmu. \u00DA\u010Dinek polymern\u00EDho nosi\u010De konjugovan\u00E9ho s kancerostatikem je zam\u011B\u0159en na c\u00EDlenou terapii n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED v hum\u00E1nn\u00ED medic\u00EDn\u011B." . . . .