"DE - Spolkov\u00E1 republika N\u011Bmecko" . "Glycosyl Azides \u2013 An Alternative Way to Disaccharides"@en . . "[E1DFD2F895BC]" . "6"^^ . "8"^^ . . . "Glycosyl Azides \u2013 An Alternative Way to Disaccharides" . "Bojarov\u00E1, Pavla" . . "RIV/61388971:_____/07:00097666!RIV08-AV0-61388971" . "azides; enzyme calatysis; glycosylation"@en . . . "Kuzma, Marek" . "Ferrandi, E. E." . . "Monti, D." . "7"^^ . . . "RIV/61388971:_____/07:00097666" . . . "Pelantov\u00E1, Helena" . "349" . "P(GA203/05/0172), P(IAA400200503), P(OC 136), P(OC 170), P(OC D25.001), V, Z(AV0Z50200510)" . "1514;1520" . . . . "Petr\u00E1skov\u00E1, Lucie" . "Glycosyl Azides \u2013 An Alternative Way to Disaccharides"@en . "Simersk\u00E1, Pavla" . "Glykosyl azidy \u2013 alternativn\u00ED cesta k disacharid\u016Fm"@cs . . . . . . . . . "8-9" . "Advanced Synthesis & Catalysis" . "K\u0159en, Vladim\u00EDr" . . "Glycosyl azides are shown to be efficient donors for Alfa-galactosidases, Alfa-glucosidases and Alfa-mannosidases. Only Alfa-galactosidases do not cleave the respective glycosyl azide 1 and, moreover, they exhibit competitive inhibition (especially Alfa-galactosidase from Talaromyces flavus). High water solubility and ready synthesis of glycosyl azides enable transglycosylation reactions even with difficult acceptors like N-acetyl-D-mannosamine in good yields. The versatility of glycosyl azides was demonstrated in the synthesis of five disaccharides \u2013 two of them are described for the first time. All the reactions were highly regioselective, yielding isomers. Alfa-Galactosidase from E. coli proved to have the best synthetic capabilities. The present study shows that glycosyl azides are a valuable alternative to common p-nitrophenyl glycoside donors and in many synthetic reactions"@en . . "1615-4150" . . "Pr\u00E1ce ukazuje, \u017Ee glykosylazidy jsou efektivn\u00ED donory pro Alfa-galaktosidasy, Alfa-glukosidasy a Alfa-mannosidasy. Pouze Alfa-galaktosidasy ne\u0161t\u011Bp\u00ED glykosylazid 1 a nav\u00EDc vykazuj\u00ED kompetitivn\u00ED inhibici (zvl\u00E1\u0161t\u011B Alfa-galaktosidasa z Talaromyces flavus). V\u00FDborn\u00E1 rozpustnost ve vod\u011B a jednoduch\u00E1 synt\u00E9za glykosylazid\u016F umo\u017E\u0148uj\u00ED transglykosyla\u010Dn\u00ED reakce s dobr\u00FDmi v\u00FDt\u011B\u017Eky i s problematick\u00FDmi akceptory jako N-acetyl-D-mannosamin. V\u0161estrannost glykosylazid\u016F byla demonstrov\u00E1na na synt\u00E9ze p\u011Bti disacharid\u016F, z nich\u017E dva jsou pops\u00E1ny poprv\u00E9. V\u0161echny reakce byly vysoce regioselektivn\u00ED a vznikaly p\u0159i nich isomery. Alfa-Galaktosidasa z E. coli m\u011Bla nejlep\u0161\u00ED syntetick\u00E9 schopnosti. Tato studie ukazuje, \u017Ee glykosylazidy jsou cennou alternativou b\u011B\u017En\u011B pou\u017E\u00EDvan\u00FDch p-nitrofenyl-glykosidov\u00FDch donor\u016F v mnoha syntetick\u00FDch reakc\u00EDch"@cs . . "Glycosyl Azides \u2013 An Alternative Way to Disaccharides" . "423503" . "Glykosyl azidy \u2013 alternativn\u00ED cesta k disacharid\u016Fm"@cs . "Glycosyl azides are shown to be efficient donors for Alfa-galactosidases, Alfa-glucosidases and Alfa-mannosidases. Only Alfa-galactosidases do not cleave the respective glycosyl azide 1 and, moreover, they exhibit competitive inhibition (especially Alfa-galactosidase from Talaromyces flavus). High water solubility and ready synthesis of glycosyl azides enable transglycosylation reactions even with difficult acceptors like N-acetyl-D-mannosamine in good yields. The versatility of glycosyl azides was demonstrated in the synthesis of five disaccharides \u2013 two of them are described for the first time. All the reactions were highly regioselective, yielding isomers. Alfa-Galactosidase from E. coli proved to have the best synthetic capabilities. The present study shows that glycosyl azides are a valuable alternative to common p-nitrophenyl glycoside donors and in many synthetic reactions" . .