"\u0160ebo, Peter" . . "[C85C6B2B673F]" . "Segments Crucial for Membrane Translocation and Pore-forming Activity of Bordetella Adenylate Cyclase Toxin" . "Segments Crucial for Membrane Translocation and Pore-forming Activity of Bordetella Adenylate Cyclase Toxin"@en . . "Ma\u0161\u00EDn, Ji\u0159\u00ED" . . "Segmenty kl\u00ED\u010Dov\u00E9 pro translokaci a kan\u00E1lotvornou aktivitu adenyl\u00E1t-cykl\u00E1zov\u00E9ho toxinu z Bordetella pertussis"@cs . "4"^^ . "Journal of Biological Chemistry" . "RIV/61388971:_____/07:00085770" . "12419;12429" . "11"^^ . . . "0021-9258" . "Segments Crucial for Membrane Translocation and Pore-forming Activity of Bordetella Adenylate Cyclase Toxin" . . "RIV/61388971:_____/07:00085770!RIV08-AV0-61388971" . "Osi\u010Dka, Radim" . "bordetella; adenylate cyclase toxin; ac membrane translocation"@en . "Uk\u00E1zali jsme, \u017Ee translokace AC dom\u00E9ny a kan\u00E1lotvorn\u00E1 (hemolytick\u00E1) aktivita CyaA z\u00E1vis\u00ED na predikovan\u00E9m transmebr\u00E1nov\u00E9m amfipatick\u00E9m \u03B1-helixu, kter\u00FD je lokalizov\u00E1n mezi aminokyselinov\u00FDmi zbytky 565 a 591 v hydrof\u00F3bn\u00ED dom\u00E9n\u011B a zahrnuje dva glutam\u00E1tov\u00E9 zbytky, Glu570 a Glu581. D\u00E1le jsme poprv\u00E9 uk\u00E1zali, \u017Ee r\u016Fzn\u00E9 aminokyselinov\u00E9 z\u00E1m\u011Bny glutam\u00E1tov\u00E9ho zbytku v pozici 516 mohou zvy\u0161ovat hemolytickou aktivitu CyaA dv\u011Bmi r\u016Fzn\u00FDmi molekul\u00E1rn\u00EDmi mechanizmy"@cs . . . . "17" . . . "Knapp, O." . "449197" . "We show that AC membrane translocation and pore-forming (hemolytic) activity of CyaA depends on a predicted transmembrane amphipathic \u03B1-helix, localized between residues 565 and 591 of the pore-forming domain and comprising pair of glutamate residues, Glu570 and Glu581. Moreover, we show for the first time that different amino acid substitutions of the glutamate residue at position 516 can increase the hemolytic activity of CyaA by two different molecular mechanisms" . "Fi\u0161er, R." . . "P(1M0506), P(IAA5020406), R, Z(AV0Z50200510)" . "We show that AC membrane translocation and pore-forming (hemolytic) activity of CyaA depends on a predicted transmembrane amphipathic \u03B1-helix, localized between residues 565 and 591 of the pore-forming domain and comprising pair of glutamate residues, Glu570 and Glu581. Moreover, we show for the first time that different amino acid substitutions of the glutamate residue at position 516 can increase the hemolytic activity of CyaA by two different molecular mechanisms"@en . . . "Segments Crucial for Membrane Translocation and Pore-forming Activity of Bordetella Adenylate Cyclase Toxin"@en . . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Maier, E." . . . . "Basler, Marek" . "8"^^ . "Benz, R." . "282" . "Segmenty kl\u00ED\u010Dov\u00E9 pro translokaci a kan\u00E1lotvornou aktivitu adenyl\u00E1t-cykl\u00E1zov\u00E9ho toxinu z Bordetella pertussis"@cs . . .