. "4168;4179" . . . "0021-9193" . . "Journal of Bacteriology" . "Serin-threoninov\u00E1 proteinkinasa StkP jako glob\u00E1ln\u00ED regul\u00E1tor genov\u00E9 exprese Streptococcus pneumoniae"@cs . . "Nov\u00E1kov\u00E1, Linda" . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Eukaryotic-Type Serine/Threonine Protein Kinase StkP Is a Global Regulator of Gene Expression in Streptococcus pneumoniae" . "Eukaryotic-Type Serine/Threonine Protein Kinase StkP Is a Global Regulator of Gene Expression in Streptococcus pneumoniae" . . . . "420591" . . . . "189" . . "11"^^ . "Serin-threoninov\u00E1 proteinkinasa StkP jako glob\u00E1ln\u00ED regul\u00E1tor genov\u00E9 exprese Streptococcus pneumoniae"@cs . . "Tato studie se zab\u00FDv\u00E1 anal\u00FDzou funkce proteinkinasy eukaryotn\u00EDho typu StkP u Streptococcus pneumoniae. Bylo zji\u0161t\u011Bno, \u017Ee exprese StkP je d\u016Fle\u017Eit\u00E1 pro rezistenci S. pneumoniae k r\u016Fzn\u00FDm druh\u016Fm stres\u016F. D\u00E1le byly porovn\u00E1ny expresn\u00ED profily kmen\u016F divok\u00E9ho typu a mutanta \u0394stkP a bylo prok\u00E1z\u00E1no, \u017Ee StkP kontroluje expresi gen\u016F k\u00F3duj\u00EDc\u00EDch proteiny rozli\u010Dn\u00E9 funkce"@cs . "Eukaryotic-Type Serine/Threonine Protein Kinase StkP Is a Global Regulator of Gene Expression in Streptococcus pneumoniae"@en . . "RIV/61388971:_____/07:00084887!RIV08-AV0-61388971" . "Signal transduction pathways in both prokaryotes and eukaryotes utilize protein phosphorylation as a key regulatory mechanism. Recent studies have proven that eukaryotic-type serine/threonine protein kinases (Hanks-type) are widespread in many bacteria, although little is known regarding the cellular processes they control. In this study, we have attempted to establish the role of a single eukaryotic-type protein kinase, StkP of Streptococus pneumoniae, in bacterial survival. Our results indicate that expression of StkP is important for the resistance of S. pneumoniae to various stress conditions. To investigate the impact of StkP on this phenotype, we compared the whole-genome expression profiles of the wild type and \u0394stkP mutant strains by microarray technology. This analysis revealed that StkP positively controls transcription of a set of genes encoding functions involved in cell wall metabolism, pyrimidine biosynthesis, DNA repair, iron uptake and oxidative stress response" . "4"^^ . "Branny, Pavel" . "4"^^ . "[35B9D90B9912]" . . "11" . . . "Basler, Marek" . . "P\u0159enosilov\u00E1, Lenka" . "Eukaryotic-Type Serine/Threonine Protein Kinase StkP Is a Global Regulator of Gene Expression in Streptococcus pneumoniae"@en . . "Signal transduction pathways in both prokaryotes and eukaryotes utilize protein phosphorylation as a key regulatory mechanism. Recent studies have proven that eukaryotic-type serine/threonine protein kinases (Hanks-type) are widespread in many bacteria, although little is known regarding the cellular processes they control. In this study, we have attempted to establish the role of a single eukaryotic-type protein kinase, StkP of Streptococus pneumoniae, in bacterial survival. Our results indicate that expression of StkP is important for the resistance of S. pneumoniae to various stress conditions. To investigate the impact of StkP on this phenotype, we compared the whole-genome expression profiles of the wild type and \u0394stkP mutant strains by microarray technology. This analysis revealed that StkP positively controls transcription of a set of genes encoding functions involved in cell wall metabolism, pyrimidine biosynthesis, DNA repair, iron uptake and oxidative stress response"@en . "P(1G46068), P(GA204/02/1423), P(GP204/07/P082), Z(AV0Z50200510)" . . . "RIV/61388971:_____/07:00084887" . "protein kinase; streptococus pneumoniae; gene expression"@en .