"Ga\u017E\u00E1k, Radek" . "488494" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . . "8"^^ . . . . "Bioorganic Medical Chemistry" . "RIV/61388971:_____/06:00043280!RIV07-GA0-61388971" . "Byla p\u0159ipravena \u0159ada selektivn\u011B alkylovan\u00FDch deriv\u00E1t\u016F silybinu a 2,3-dehydrosilybinu ur\u010Den\u00FDch pro strukturn\u011B-aktivitn\u00ED studie jejich efektu na inhibici effluxn\u00ED funkce P-glykoproteinu. P\u0159ipraven\u00E9 deriv\u00E1ty silybinu/2,3-dehydrosilybinu byly testov\u00E1ny rovn\u011B\u017E na cytotoxicitu v panelu bun\u011Bk citliv\u00FDch a rezistentn\u00EDch k l\u00E9\u010Divu. Identifikovali jsme efektivn\u00ED a relativn\u011B netoxick\u00E9 inhibitory P-gp odvozen\u00E9 od 2,3-dehydrosilybinu. \u0158ada z nich vykazovala lep\u0161\u00ED inhibi\u010Dn\u00ED aktivitu ne\u017E standardn\u00ED P-gp inhibitor cyklosporin A. V r\u00E1mci t\u00E9to studie byly tak\u00E9 stanoveny strukturn\u00ED po\u017Eadavky pro zlep\u0161en\u00ED inhibi\u010Dn\u00ED aktivity a sn\u00ED\u017Een\u00ED toxicity 2,3-dehydrosilybinu"@cs . "[F16AE4BB8A4F]" . "Walterov\u00E1, Daniela" . . "Large series of O-alkyl derivatives of silybin and 2,3-dehydrosilybin was prepared. All prepared silybin/2,3-dehydrosilybin derivatives were tested for cytotoxicity on a panel of drugs sensitive against multidrug resistant cell lines and the ability to inhibit P-glycoprotein mediated efflux activity. We have identified effective and relatively non-cytotoxic inhibitors of P-gp derived from 2,3-dehydrosilybin. Some of them were more effective inhibitors than a standard P-gp efflux inhibitor cyclosporin A. In the frame of this study were established structural requirements for improving inhibitory activity and reducing toxicity of 2,3-dehydrosilybin as well" . "RIV/61388971:_____/06:00043280" . . "3"^^ . "D\u017Eub\u00E1k, P." . "New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity" . "3793;3810" . "-" . "silymarin; silybin; dehydrosilybin"@en . . "P(GA303/02/1097), Z(AV0Z50200510), Z(MSM6198959216)" . "Large series of O-alkyl derivatives of silybin and 2,3-dehydrosilybin was prepared. All prepared silybin/2,3-dehydrosilybin derivatives were tested for cytotoxicity on a panel of drugs sensitive against multidrug resistant cell lines and the ability to inhibit P-glycoprotein mediated efflux activity. We have identified effective and relatively non-cytotoxic inhibitors of P-gp derived from 2,3-dehydrosilybin. Some of them were more effective inhibitors than a standard P-gp efflux inhibitor cyclosporin A. In the frame of this study were established structural requirements for improving inhibitory activity and reducing toxicity of 2,3-dehydrosilybin as well"@en . "8"^^ . . "New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity"@en . "Nov\u00E9 deriv\u00E1ty silybinu a 2,3-dehydrosilybinu - jejich cytotoxicita a P-glykoprotein modula\u010Dn\u00ED aktivita"@cs . . "0968-0896" . . "14" . . "Sedmera, Petr" . "Nov\u00E9 deriv\u00E1ty silybinu a 2,3-dehydrosilybinu - jejich cytotoxicita a P-glykoprotein modula\u010Dn\u00ED aktivita"@cs . "New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity" . "Hajd\u00FAch, M." . . . . "Psotov\u00E1, J." . . "K\u0159en, Vladim\u00EDr" . . "Svobodov\u00E1, A." . . . . "New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity"@en .